| Jul 27, 2026 (view filing)7:30 PM ET | Jul 23-24 | 4 days | Harmon CyrusDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −25.0K | $11.65 | −$291.2K | −3.4%702.8K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Mar 5, 2026 (view filing) | Mar 3-4 | 2 days | Mitchell ShawnteCHIEF LEGAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −39.8K | $23.78 | −$945.7K | −99.4%233 after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Mar 5, 2026 (view filing) | Mar 4 | 1 day | Mitchell ShawnteCHIEF LEGAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Comon Stock | −233 | $24.69 | −$5.75K | −100.0%0 after | |
| Jan 21, 2026 (view filing) | Jan 20 | 1 day | Harmon CyrusDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.0K | $26.88 | −$268.8K | −1.4%727.8K after | |
| Jan 16, 2026 (view filing) | Jan 14 | 2 days | Harmon CyrusDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3.49K | $29.12 | −$101.6K | −0.5%737.8K after | |
| Jan 15, 2026 (view filing) | Jan 13-15 | 2 days | Kovacs Shane William CharlesCH. OPERATING & FINANCIAL OFF. | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −103.8K | $28.70 | −$2.98M | −42.6%139.7K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 14, 2026 (view filing) | Jan 12 | 2 days | Myles David C.CH. DISCOV. & NON-CLIN DEV OFF | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.0K | $28.34 | −$283.4K | −6.5%144.8K after | |
| Jan 14, 2026 (view filing) | Jan 13-14 | 1 day | Myles David C.CH. DISCOV. & NON-CLIN DEV OFF | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −100.0K | $28.24 | −$2.82M | −15.6%542.8K after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 29, 2025 (view filing) | Dec 22 | 7 days | Harmon CyrusDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.88K | $28.53 | −$82.2K | −0.4%741.3K after | |
| Dec 23, 2025 (view filing) | Dec 19-23 | 4 days | Zojwalla NaseemChief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −269.5K | $27.94 | −$7.53M | −98.4%4.49K after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 23, 2025 (view filing) | Dec 19 | 4 days | Myles David C.CH. DISCOV. & NON-CLIN DEV OFF | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −51.0K | $30.46 | −$1.55M | −8.5%551.9K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 23, 2025 (view filing) | Dec 19 | 4 days | Clark Ian TDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −264.8K | $29.73 | −$7.87M | −100.0%0 after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Sep 18, 2025 (view filing) | Sep 16-18 | 2 days | Harmon CyrusDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −20.0K | $8.19 | −$163.7K | −2.6%744.1K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Sep 18, 2025 (view filing) | Sep 16-18 | 2 days | Harmon CyrusDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −5.00K | $8.23 | −$41.1K | −4.1%117.0K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 13, 2025 (view filing)4:34 PM ET | Jan 8 | 5 days | Bain Capital Life Sciences Investors, LLC and 4 others10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +300.0K | $5.76 | +$1.73M | +4.0%7.80M after | |
| Dec 18, 2024 (view filing) | Dec 13 | 5 days | Graham G. WalmsleyDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −700.8K | $6.75 | −$4.73M | −100.0%0 after | From originalReported on the original filing 0000935836-24-000764. A later amendment (Form 4/A) restated only part of that filing, so this trade still stands and is listed under the amendment. The filing date shown is the original's. |
| Dec 18, 2024 (view filing) | Dec 13 | 5 days | Graham G. WalmsleyDirector | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +700.8K | $6.75 | +$4.73M | New position700.8K after | From originalReported on the original filing 0000935836-24-000764. A later amendment (Form 4/A) restated only part of that filing, so this trade still stands and is listed under the amendment. The filing date shown is the original's. |
| Dec 11, 2024 (view filing) | Dec 10-11 | 1 day | Harmon CyrusDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −16.4K | $9.03 | −$148.0K | −2.1%764.1K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 11, 2024 (view filing) | Dec 10-11 | 1 day | Myles David C.CH. DISCOV. & NON-CLIN DEV OFF | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −26.1K | $9.01 | −$234.9K | −4.2%598.3K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 11, 2024 (view filing) | Dec 10-11 | 1 day | Zojwalla NaseemCHIEF MEDICAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −27.8K | $9.01 | −$250.5K | −19.4%115.5K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 11, 2024 (view filing) | Dec 10-11 | 1 day | Kovacs Shane William CharlesCH. OPERATING & FINANCIAL OFF. | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −35.2K | $9.01 | −$316.7K | −6.1%543.5K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 11, 2024 (view filing) | Dec 10-11 | 1 day | Bohen SeanPRESIDENT AND CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −109.5K | $9.01 | −$986.4K | −31.2%241.7K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Nov 26, 2024 (view filing) | Jun 4 | 175 days | Graham G. WalmsleyDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.18M | $14.85 | −$17.4M | −62.4%708.1K after | AmendedAn amended filing (for example Form 4/A or 13F-HR/A) that corrects or adds to an earlier filing.2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Aug 5, 2024 (view filing)4:30 PM ET | Aug 1 | 4 days | Paradigm BioCapital International Fund Ltd. and 3 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock, par value $0.0001 per share | −2.40M | $14.92 | −$35.8M | −75.4%783.1K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jul 31, 2024 (view filing) | Jul 29-30 | 2 days | Harmon CyrusDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −5.00K | $15.57 | −$77.9K | −0.7%751.3K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jul 12, 2024 (view filing) | Jul 11 | 1 day | Harmon CyrusDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −5.00K | $12.26 | −$61.3K | −0.7%756.3K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jul 2, 2024 (view filing) | Jun 28 | 4 days | Harmon CyrusDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −20.0K | $10.77 | −$215.4K | −2.6%761.3K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jun 4, 2024 (view filing) | May 31-Jun 4 | 4 days | Harmon CyrusDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −25.0K | $10.30 | −$257.4K | −3.1%781.3K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| May 7, 2024 (view filing) | May 6 | 1 day | Harmon CyrusDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −5.00K | $10.92 | −$54.6K | −0.6%806.3K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| May 2, 2024 (view filing) | Apr 30 | 2 days | Harmon CyrusDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −15.0K | $9.51 | −$142.7K | −1.8%811.3K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Mar 29, 2024 (view filing) | Mar 28 | 1 day | Harmon CyrusDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −20.0K | $10.97 | −$219.4K | −2.4%826.3K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Mar 4, 2024 (view filing) | Feb 29 | 4 days | Harmon CyrusDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −25.0K | $12.41 | −$310.3K | −2.9%846.3K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Feb 2, 2024 (view filing) | Jan 31-Feb 1 | 2 days | Harmon CyrusDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −30.0K | $12.79 | −$383.6K | −3.3%871.3K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jan 2, 2024 (view filing) | Dec 29, 2023 | 4 days | Harmon CyrusDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −25.0K | $13.38 | −$334.5K | −2.7%901.3K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 18, 2023 (view filing) | Sep 12-Dec 5 | 97 daysLateFiled more than 2 business days after the trade (the Form 4 deadline). A few cases, such as trades a broker makes under a 10b5-1 plan, have a longer deadline, so this flag comes from the dates alone and does not mean a rule was broken. | Graham G. WalmsleyDirector | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +640.0K | $10.74 | +$6.87M | +55.2%1.80M after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 8, 2023 (view filing)4:19 PM ET | Dec 6 | 2 days | Paradigm BioCapital International Fund Ltd. and 3 others10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in.Common Stock, par value $0.0001 per share | +100.0K | $11.60 | +$1.16M | +1.5%6.59M after | |
| Dec 1, 2023 (view filing) | Nov 30 | 1 day | Harmon CyrusDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −25.0K | $12.57 | −$314.3K | −2.6%926.3K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Nov 22, 2023 (view filing) | Nov 21-22 | 1 day | Zojwalla NaseemCHIEF MEDICAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −14.6K | $14.38 | −$209.3K | −32.2%30.7K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Nov 22, 2023 (view filing) | Nov 21-22 | 1 day | Myles David C.CH. DISCOV. & NON-CLIN DEV OFF | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −13.6K | $14.40 | −$196.2K | −2.3%574.1K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Nov 22, 2023 (view filing) | Nov 21-22 | 1 day | Harmon CyrusDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −8.18K | $14.39 | −$117.7K | −0.9%951.3K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Nov 22, 2023 (view filing) | Nov 21-22 | 1 day | Bohen SeanPRESIDENT AND CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −57.2K | $14.40 | −$824.1K | −28.3%144.9K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Nov 22, 2023 (view filing) | Nov 21-22 | 1 day | Kovacs Shane William CharlesCH. OPERATING & FINANCIAL OFF. | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −18.7K | $14.39 | −$269.7K | −4.2%425.0K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Nov 13, 2023 (view filing) | Nov 8 | 5 days | Myles David C.CH. DISCOV. & NON-CLIN DEV OFF | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −200 | $17.61 | −$3.52K | 0.0%561.3K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Nov 3, 2023 (view filing) | Nov 1-3 | 2 days | Myles David C.CH. DISCOV. & NON-CLIN DEV OFF | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.5K | $15.26 | −$160.8K | −1.8%561.5K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Nov 2, 2023 (view filing) | Oct 31-Nov 2 | 2 days | Harmon CyrusDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −30.0K | $12.65 | −$379.4K | −3.1%943.7K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Oct 3, 2023 (view filing) | Sep 29 | 4 days | Harmon CyrusDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −25.0K | $12.41 | −$310.3K | −2.5%973.7K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Sep 21, 2023 (view filing) | Sep 19 | 2 days | Myles David C.CH. DISCOV. & NON-CLIN DEV OFF | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −20.0K | $12.67 | −$253.4K | −3.4%572.0K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Sep 14, 2023 (view filing)4:25 PM ET | Sep 12 | 2 days | Biotechnology Value Fund L P and 9 othersDirector, Other: See Explanation of Responses | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in.Common stock, $0.0001 par value | +1.51M | $9.84 | +$14.8M | New position524.2K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Sep 5, 2023 (view filing) | Aug 31-Sep 5 | 5 days | Harmon CyrusDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −25.0K | $10.26 | −$256.6K | −2.4%998.7K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Sep 5, 2023 (view filing) | Aug 16 | 20 days | Harmon CyrusDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −15.0K | $10.14 | −$152.1K | −1.4%1.02M after | AmendedAn amended filing (for example Form 4/A or 13F-HR/A) that corrects or adds to an earlier filing.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
