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Ensysce Biosciences, Inc.

ENSC
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001716947

In the last 90 days, Ensysce Biosciences, Inc. insiders filed 1 open-market purchase and 0 sales; 18 institutions reported holding it in 13F filings for Q2 2026, worth $261.1K in total; no superinvestor holds it.

13F holders, Q1 2026

Institutional positions in Ensysce Biosciences, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
15
−1 vs. Q4 2025
Shares held
487.0K
+21.1K (+4.5%) vs. Q4 2025
Total value
$261.5K
−$165.9K (−38.8%) vs. Q4 2025
New holders
6
5 more added
Sold out
7
0 more reduced

1 institution that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q4 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting ENSC on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2026: 15 institutions
Q1 2021: 0 institutionsQ2 2021: 0 institutionsQ3 2021: 16 institutionsQ4 2021: 18 institutionsQ1 2022: 21 institutionsQ2 2022: 21 institutionsQ3 2022: 20 institutionsQ4 2022: 14 institutionsQ1 2023: 10 institutionsQ2 2023: 9 institutionsQ3 2023: 12 institutionsQ4 2023: 9 institutionsQ1 2024: 10 institutionsQ2 2024: 11 institutionsQ3 2024: 13 institutionsQ4 2024: 8 institutionsQ1 2025: 9 institutionsQ2 2025: 11 institutionsQ3 2025: 17 institutionsQ4 2025: 17 institutionsQ1 2026: 15 institutionsQ2 2026: 18 institutions
Value heldQ1 2026: $261.5K
Q1 2021: $0Q2 2021: $0Q3 2021: $9.56MQ4 2021: $15.9MQ1 2022: $6.23MQ2 2022: $3.41MQ3 2022: $810.7KQ4 2022: $138.2KQ1 2023: $103.2KQ2 2023: $714.0KQ3 2023: $231.1KQ4 2023: $56.4KQ1 2024: $236.5KQ2 2024: $253.0KQ3 2024: $580.5KQ4 2024: $1.15MQ1 2025: $903.4KQ2 2025: $398.8KQ3 2025: $833.7KQ4 2025: $461.1KQ1 2026: $261.5KQ2 2026: $261.1K
Institutions holding ENSC and their total value by quarter
QuarterHoldersValue
Q2 202618$261.1K
Q1 202615$261.5K
Q4 202517$461.1K
Q3 202517$833.7K
Q2 202511$398.8K
Q1 20259$903.4K
Q4 20248$1.15M
Q3 202413$580.5K
Q2 202411$253.0K
Q1 202410$236.5K
Q4 20239$56.4K
Q3 202312$231.1K
Q2 20239$714.0K
Q1 202310$103.2K
Q4 202214$138.2K
Q3 202220$810.7K
Q2 202221$3.41M
Q1 202221$6.23M
Q4 202118$15.9M
Q3 202116$9.56M
Q2 20210$0
Q1 20210$0

Institutions, Q1 2026

Shares, value and share of portfolio for each institution holding Ensysce Biosciences, Inc.; share changes are against Q4 2025.

Institutions holding ENSC in Q1 2026
InstitutionSharesValue% of portfolioChange in sharesAction
Adage Capital Partners GP, L.L.C.149,711$80.6K0.00%00.0%Unchanged
Perceptive Advisors LLC86,666$46.7K0.00%00.0%Unchanged
Geode Capital Management, LLC73,880$39.8K0.00%+51,790+234.4%Added
Citadel Advisors LLC57,363$30.9K0.00%+57,363New
XTX Topco Ltd24,363$13.1K0.00%+24,363New
Vanguard Fiduciary Trust Co23,854$12.9K0.00%+23,854New
Jane Street Group, LLC13,570$7.31K0.00%+13,570New
Tru Independence Asset Management 2, LLC13,000$7.00K0.00%+1,000+8.3%Added
Virtu Financial LLC13,313$7.00K0.00%+13,313New
Vanguard Capital Management LLC12,854$6.93K0.00%+12,854New
UBS Group AG8,791$4.73K0.00%+8,691+8,691.0%Added
Tower Research Capital LLC (TRC)6,094$3.28K0.00%+775+14.6%Added
FNY Investment Advisers, LLC3,000$1.00K0.00%00.0%Unchanged
SBI Securities Co., Ltd.486$2620.00%+65+15.4%Added
BlackRock, Inc.65$350.00%00.0%Unchanged
DRW Securities, LLC0$00.00%−98,481−100.0%Sold out
Financial Plan, Inc.0$00.00%−24,000−100.0%Sold out
HRT Financial LP0$00.00%−24,491−100.0%Sold out
Two Sigma Securities, LLC0$00.00%−21,605−100.0%Sold out
Williams & Novak, LLC0$00.00%−17,850−100.0%Sold out
Bank of America Corp0$00.00%−72−100.0%Sold out
Jones Financial Companies LLLP0$00.00%−41−100.0%Sold out
Vanguard Group Inc––––Not filed