Skip to main content
Livermore
Livermore
ZHEN

Paradigm Biocapital Advisors LP

SEC CIK
0001855655
Latest filing
Aug 14, 2026

Holdings in Q1 2023

Holdings as of Mar 31, 2023, filed May 15, 2023. Long positions only; changes compare share counts with Q4 2022.

Institution overview
Positions
25
+2 vs. Q4 2022
Portfolio value
$1.06B
+$203.3M (+23.9%) vs. Q4 2022
Filed
May 15, 2023
SEC
Holdings of Paradigm Biocapital Advisors LP in Q1 2023
SecurityClassSharesValue% of portfolioShare changeActionHistory
BIIBBiogen Inc.COM349,593$97.2M9.2%+110,821+46.4%AddedHistory
INCYIncyte CorpCOM1,261,711$91.2M8.6%+408,881+47.9%AddedHistory
LEGNLegend Biotech CorpSPONSORED ADS1,510,324$72.8M6.9%+455,454+43.2%AddedHistory
ARGXArgenx SESPONSORED ADR181,172$67.5M6.4%+91,616+102.3%AddedHistory
SGENSeagen Inc.COM281,969$57.1M5.4%−4,319−1.5%ReducedHistory
IMCRImmunocore Holdings plcADS1,126,256$55.7M5.3%+268,331+31.3%AddedHistory
ACLXArcellx, Inc.COMMON STOCK1,757,779$54.2M5.1%+875,678+99.3%AddedHistory
VRDNViridian Therapeutics, Inc.COM2,085,698$53.1M5.0%+334,531+19.1%AddedHistory
MRTXMirati Therapeutics, Inc.COM1,396,779$51.9M4.9%+128,809+10.2%AddedHistory
SNDXSyndax Pharmaceuticals IncCOM2,274,512$48.0M4.6%+320,000+16.4%AddedHistory
UTHRUnited Therapeutics CorpCOM211,892$47.5M4.5%+63,000+42.3%AddedHistory
KROSKeros Therapeutics, Inc.COM930,752$39.7M3.8%+930,752NewHistory
ONCBeOne Medicines Ltd.ADR184,012$39.7M3.8%+184,012NewHistory
CERECerevel Therapeutics Holdings, Inc.COM1,595,199$38.9M3.7%+1,595,199NewHistory
BCYCBicycle Therapeutics PLCSPONSORED ADS1,816,781$38.6M3.7%+583,501+47.3%AddedHistory
ASNDAscendis Pharma A/SSPONSORED ADR350,866$37.6M3.6%−1,942−0.6%ReducedHistory
VORVor Biopharma Inc.COM6,477,999$34.9M3.3%+35,174+0.5%AddedHistory
ZLABZai Lab LtdADR780,558$26.0M2.5%+265,284+51.5%AddedHistory
XENEXenon Pharmaceuticals Inc.COM651,068$23.3M2.2%+651,068NewHistory
VRNAVerona Pharma plcSPONSORED ADS962,361$19.3M1.8%+962,361NewHistory
CRNXCrinetics Pharmaceuticals, Inc.COM1,133,782$18.2M1.7%+243,677+27.4%AddedHistory
ALPNAlpine Immune Sciences, Inc.COM2,317,634$17.9M1.7%00.0%UnchangedHistory
THRXTheseus Pharmaceuticals, Inc.COM1,505,327$13.4M1.3%+1,505,327NewHistory
OLMAOlema Pharmaceuticals, Inc.COM2,382,377$8.27M0.8%+2,382,377NewHistory
PSTXPoseida Therapeutics, Inc.COM1,072,410$3.30M0.3%−1,362,406−56.0%ReducedHistory

Sold out since Q4 2022 (5)

Positions held at the end of Q4 2022 that are gone from this filing.

Positions of Paradigm Biocapital Advisors LP sold out since Q4 2022
SecurityClassShares in Q4 2022Value in Q4 2022% of portfolio in Q4 2022History
HZNPHorizon Therapeutics Public Ltd CoSHS477,585$54.3M6.4%History
AKROAkero Therapeutics, Inc.COM604,544$33.1M3.9%History
KRTXKaruna Therapeutics, Inc.COM106,210$20.9M2.4%History
ARVNArvinas, Inc.COM599,599$20.5M2.4%History
PRTAProthena Corp Public Ltd CoSHS75,000$4.52M0.5%History