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Livermore
Livermore
ZHEN

Avidity Partners Management LP

SEC CIK
0001791827
Latest filing
Aug 14, 2026

Holdings in Q4 2022

Holdings as of Dec 31, 2022, filed Feb 14, 2023. Long positions only; changes compare share counts with Q3 2022.

Institution overview
Positions
84
−12 vs. Q3 2022
Portfolio value
$4.28B
−$318.5M (−6.9%) vs. Q3 2022
Filed
Feb 14, 2023
SEC
Holdings of Avidity Partners Management LP in Q4 2022
SecurityClassSharesValue% of portfolioShare changeActionHistory
ARGXArgenx SESPONSORED ADR625,000$236.8M5.5%+133,200+27.1%AddedHistory
UTHRUnited Therapeutics CorpCOM785,500$218.4M5.1%−184,700−19.0%ReducedHistory
NBIXNeurocrine Biosciences IncStock1,780,000$212.6M5.0%−75,700−4.1%ReducedHistory
AKROAkero Therapeutics, Inc.COM3,825,000$209.6M4.9%+703,000+22.5%AddedHistory
PRTAProthena Corp Public Ltd CoSHS2,953,000$177.9M4.2%+986,000+50.1%AddedHistory
ARVNArvinas, Inc.COM4,950,000$169.3M4.0%+606,500+14.0%AddedHistory
BSXBoston Scientific CorpStock3,256,700$150.7M3.5%+718,100+28.3%AddedHistory
SNDXSyndax Pharmaceuticals IncCOM5,861,000$149.2M3.5%+274,100+4.9%AddedHistory
RAREUltragenyx Pharmaceutical Inc.COM2,990,000$138.5M3.2%+938,400+45.7%AddedHistory
SRPTSarepta Therapeutics, Inc.COM1,055,000$136.7M3.2%+106,800+11.3%AddedHistory
MDGLMadrigal Pharmaceuticals, Inc.COM430,000$124.8M2.9%+430,000NewHistory
UHSUniversal Health Services IncCL B825,600$116.3M2.7%+825,600NewHistory
JAZZJazz Pharmaceuticals plcSHS USD727,541$115.9M2.7%+409,241+128.6%AddedHistory
ZNTLZentalis Pharmaceuticals, Inc.COM5,150,000$103.7M2.4%+926,900+21.9%AddedHistory
ACHCAcadia Healthcare Company, Inc.COM1,165,000$95.9M2.2%−224,200−16.1%ReducedHistory
SGRYSurgery Partners, Inc.Stock3,112,000$86.7M2.0%+2,844,400+1,062.9%AddedHistory
DXCMDexcom IncCOM756,800$85.7M2.0%+289,200+61.8%AddedHistory
AZNAstraZeneca PLCSPONSORED ADR1,200,000$81.4M1.9%+636,800+113.1%AddedHistory
LLYEli Lilly & CoStock217,000$79.4M1.9%−790,000−78.5%ReducedHistory
PCVXVaxcyte, Inc.COM1,615,400$77.5M1.8%+986,700+156.9%AddedHistory
Avidity Biosciences, Inc.05370A108COM3,275,000$72.7M1.7%+675,000+26.0%Added–
NTRANatera, Inc.COM1,798,900$72.3M1.7%+63,900+3.7%AddedHistory
IDYAIDEAYA Biosciences, Inc.COM3,824,800$69.5M1.6%+109,400+2.9%AddedHistory
IMCRImmunocore Holdings plcADS1,154,000$65.9M1.5%−925,100−44.5%ReducedHistory
ALTAltimmune, Inc.COM NEW3,990,000$65.6M1.5%+1,306,000+48.7%AddedHistory
RVMDRevolution Medicines, Inc.COM2,475,000$59.0M1.4%+153,800+6.6%AddedHistory
KRTXKaruna Therapeutics, Inc.COM299,000$58.8M1.4%−132,800−30.8%ReducedHistory
ARWRArrowhead Pharmaceuticals, Inc.COM1,375,000$55.8M1.3%+119,626+9.5%AddedHistory
AXSMAxsome Therapeutics, Inc.COM670,000$51.7M1.2%−868,600−56.5%ReducedHistory
VRTXVertex Pharmaceuticals IncStock172,000$49.7M1.2%−340,800−66.5%ReducedHistory
LEGNLegend Biotech CorpSPONSORED ADS970,000$48.4M1.1%+970,000NewHistory
KZRKezar Life Sciences, Inc.COM6,782,400$47.7M1.1%+1,368,000+25.3%AddedHistory
PLRXPliant Therapeutics, Inc.COM2,240,400$43.3M1.0%+259,300+13.1%AddedHistory
VTYXVentyx Biosciences, Inc.COM1,285,000$42.1M1.0%+1,285,000NewHistory
ICLRIcon PLCCOM215,000$41.8M1.0%+215,000NewHistory
DGXQuest Diagnostics IncCOM258,000$40.4M0.9%+258,000NewHistory
BIOBio-Rad Laboratories, Inc.CL A92,200$38.8M0.9%−52,600−36.3%ReducedHistory
Bellus Health Inc New07987C204COM NEW4,599,998$37.8M0.9%+253,298+5.8%Added–
THCTenet Healthcare CorpCOM NEW717,300$35.0M0.8%+717,300NewHistory
KPTIKaryopharm Therapeutics Inc.COM9,633,911$32.8M0.8%+9,633,911NewHistory
BNTXBioNTech SESPONSORED ADS215,400$32.4M0.8%+215,400NewHistory
VERVVerve Therapeutics, Inc.COM1,565,000$30.3M0.7%+522,294+50.1%AddedHistory
RCKTRocket Pharmaceuticals, Inc.COM1,527,087$29.9M0.7%+1,527,087NewHistory
ITCIIntra-Cellular Therapies, Inc.COM504,000$26.7M0.6%−898,500−64.1%ReducedHistory
ARQTArcutis Biotherapeutics, Inc.COM1,755,000$26.0M0.6%+960,500+120.9%AddedHistory
RXDXPrometheus Biosciences, Inc.COM204,000$22.4M0.5%+204,000NewHistory
NTLAIntellia Therapeutics, Inc.COM638,200$22.3M0.5%−360,900−36.1%ReducedHistory
VIRVir Biotechnology, Inc.COM850,000$21.5M0.5%+850,000NewHistory
PHATPhathom Pharmaceuticals, Inc.COM1,900,000$21.3M0.5%−6,800−0.4%ReducedHistory
BHVNBiohaven Ltd.COM1,492,000$20.7M0.5%+1,492,000NewHistory
CYTKCytokinetics IncCOM NEW420,700$19.3M0.5%+85,700+25.6%AddedHistory
DCPHDeciphera Pharmaceuticals, Inc.COM1,126,000$18.5M0.4%−65,800−5.5%ReducedHistory
CRBUCaribou Biosciences, Inc.COM2,882,600$18.1M0.4%−290,000−9.1%ReducedHistory
ISEEIVERIC bio, Inc.COM838,407$18.0M0.4%+838,407NewHistory
PNTPOINT Biopharma Global Inc.COM2,432,400$17.7M0.4%−387,600−13.7%ReducedHistory
NSTGNS Wind Down Co., Inc.COM2,057,200$16.4M0.4%+1,359,000+194.6%AddedHistory
TWSTTwist Bioscience CorpCOM611,000$14.5M0.3%+611,000NewHistory
BCABBioAtla, Inc.COM1,260,000$10.4M0.2%+1,260,000NewHistory
CMPXCompass Therapeutics, Inc.COM2,000,000$10.1M0.2%00.0%UnchangedHistory
SGMOQSangamo Therapeutics, IncCOM2,748,300$8.63M0.2%+387,500+16.4%AddedHistory
ALPNAlpine Immune Sciences, Inc.COM1,028,200$7.56M0.2%+29,600+3.0%AddedHistory
KNTEKinnate Biopharma Inc.COM1,212,700$7.40M0.2%+890.0%AddedHistory
ANTXAN2 Therapeutics, Inc.COM743,600$7.09M0.2%+970+0.1%AddedHistory
IPSCCentury Therapeutics, Inc.COM1,303,600$6.69M0.2%00.0%UnchangedHistory
Medicus Sciences AcquisitionG5960S108CL A SHS520,000$5.24M0.1%00.0%Unchanged–
LENZLENZ Therapeutics, Inc.COM1,575,000$5.23M0.1%00.0%UnchangedHistory
ARYDARYA Sciences Acquisition Corp IVCL A500,000$5.05M0.1%00.0%UnchangedHistory
Panacea Acquisition Corp. IIG6882C106CL A SHS500,000$5.03M0.1%00.0%Unchanged–
EPIXESSA Pharma Inc.COM NEW1,855,400$4.68M0.1%−604,600−24.6%ReducedHistory
OBIOOrchestra BioMed Holdings, Inc.ORD SHS400,000$3.99M0.1%00.0%UnchangedHistory
SYRSSyros Pharmaceuticals, Inc.COM NEW900,000$3.23M0.1%00.0%UnchangedHistory
CYTCyteir Therapeutics, Inc.COM1,795,800$2.96M0.1%−10,400−0.6%ReducedHistory
CMAXCareMax, Inc.COM CL A755,329$2.76M0.1%00.0%UnchangedHistory
DNABSocial Capital Suvretta Holdings Corp. IICLASS A ORD SHS200,000$2.01M<0.1%00.0%UnchangedHistory
DNADSocial Capital Suvretta Holdings Corp. IVCLASS A ORD SHS200,000$2.01M<0.1%00.0%UnchangedHistory
SCYXScynexis IncCOM NEW1,140,600$1.78M<0.1%00.0%UnchangedHistory
HYPRHyperfine, Inc.COM CL A1,503,754$1.26M<0.1%00.0%UnchangedHistory
FATEFate Therapeutics IncCOM104,653$1.06M<0.1%+104,653NewHistory
ZLABZai Lab LtdADR31,309$961.2K<0.1%−1,202,691−97.5%ReducedHistory
COLLCollegium Pharmaceutical, IncCOM37,898$879.2K<0.1%+37,898NewHistory
ACIUAC Immune SASHS325,400$663.8K<0.1%+50,524+18.4%AddedHistory
Reunion Neuroscience Inc76134G103COM560,300$504.3K<0.1%−34,900−5.9%Reduced–
Nuvation Bio Inc.67080N119*W EXP 07/07/20299,999$14.4K<0.1%00.0%Unchanged–
Medicus Sciences AcquisitionG5960S124*W EXP 02/12/20257,770$5.20K<0.1%00.0%Unchanged–

Options (1)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Avidity Partners Management LP in Q4 2022
SecurityClassPutsCalls
State Street SPDR S&P Biotech ETF78464A870ETF–$337.1M

Sold out since Q3 2022 (30)

Positions held at the end of Q3 2022 that are gone from this filing.

Positions of Avidity Partners Management LP sold out since Q3 2022
SecurityClassShares in Q3 2022Value in Q3 2022% of portfolio in Q3 2022History
BIIBBiogen Inc.COM600,000$160.2M3.5%History
State Street SPDR S&P Biotech ETF78464A870ETF1,480,000$117.4M2.6%–
HUMHumana IncStock212,000$102.9M2.2%History
ELVElevance Health, Inc.Stock207,600$94.3M2.1%History
HZNPHorizon Therapeutics Public Ltd CoSHS1,482,200$91.7M2.0%History
AVTRAvantor, Inc.COM4,522,600$88.6M1.9%History
CTLTCatalent, Inc.COM940,000$68.0M1.5%History
SGENSeagen Inc.COM445,500$61.0M1.3%History
ALNYAlnylam Pharmaceuticals, Inc.COM288,500$57.7M1.3%History
APLSApellis Pharmaceuticals, Inc.COM844,000$57.6M1.3%History
SYKStryker CorpStock184,700$37.4M0.8%History
CNCCentene CorpStock432,400$33.6M0.7%History
NGMNGM Biopharmaceuticals IncCOM1,798,100$23.5M0.5%History
COGTCogent Biosciences, Inc.COM1,357,700$20.3M0.4%History
NKTXNkarta, Inc.COM1,414,082$18.6M0.4%History
ONCBeOne Medicines Ltd.ADR132,000$17.8M0.4%History
SIBNSI-BONE, Inc.COM996,700$17.4M0.4%History
GOSSGossamer Bio, Inc.COM1,450,000$17.4M0.4%History
ATECAlphatec Holdings, Inc.COM NEW1,715,000$15.0M0.3%History
IOVAIovance Biotherapeutics, Inc.COM1,382,900$13.2M0.3%History
TMDXTransMedics Group, Inc.COM300,000$12.5M0.3%History
STOKStoke Therapeutics, Inc.COM891,100$11.4M0.2%History
SPNESeaSpine Holdings CorpCOM2,010,000$11.4M0.2%History
ERASErasca, Inc.COM982,500$7.66M0.2%History
BCLS Acquisition CorpG0904B105COM CL A500,000$5.01M0.1%–
TNGXTango Therapeutics, Inc.COM813,700$2.95M0.1%History
ONCSOncosec Medical IncCOM2,945,000$1.44M<0.1%History
WGSGeneDx Holdings Corp.COMMON STOCK950,000$834.0K<0.1%History
PHASPhaseBio Pharmaceuticals IncCOM4,361,365$768.0K<0.1%History
SNCEScience 37 Holdings, Inc.COM430,000$692.0K<0.1%History