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Livermore
ZHEN

Avidity Partners Management LP

SEC CIK
0001791827
Latest filing
Aug 14, 2026

Holdings in Q3 2021

Holdings as of Sep 30, 2021, filed Nov 15, 2021. Long positions only; changes compare share counts with Q2 2021.

Institution overview
Positions
103
−9 vs. Q2 2021
Portfolio value
$3.92B
+$222.6M (+6.0%) vs. Q2 2021
Filed
Nov 15, 2021
SEC
Holdings of Avidity Partners Management LP in Q3 2021
SecurityClassSharesValue% of portfolioShare changeActionHistory
MRTXMirati Therapeutics, Inc.COM1,062,400$187.9M4.8%+309,400+41.1%AddedHistory
ARVNArvinas, Inc.COM2,234,700$183.6M4.7%+380,700+20.5%AddedHistory
ABBVAbbVie Inc.Stock1,613,200$174.0M4.4%+128,800+8.7%AddedHistory
VRTXVertex Pharmaceuticals IncStock926,400$168.0M4.3%−23,600−2.5%ReducedHistory
ZNTLZentalis Pharmaceuticals, Inc.COM2,493,800$166.2M4.2%+333,800+15.5%AddedHistory
AVTRAvantor, Inc.COM3,247,700$132.8M3.4%+67,700+2.1%AddedHistory
BHVNBiohaven Ltd.COM934,200$129.8M3.3%+51,700+5.9%AddedHistory
SNDXSyndax Pharmaceuticals IncCOM4,823,400$92.2M2.3%+208,400+4.5%AddedHistory
REGNRegeneron Pharmaceuticals, Inc.COM152,300$92.2M2.3%+152,300NewHistory
SGENSeagen Inc.COM537,000$91.2M2.3%−103,000−16.1%ReducedHistory
HZNPHorizon Therapeutics Public Ltd CoSHS826,000$90.5M2.3%+258,000+45.4%AddedHistory
BPMCBlueprint Medicines CorpCOM832,000$85.5M2.2%+268,800+47.7%AddedHistory
AZNAstraZeneca PLCSPONSORED ADR1,412,000$84.8M2.2%+1,412,000NewHistory
NBIXNeurocrine Biosciences IncStock848,900$81.4M2.1%+167,900+24.7%AddedHistory
ALNYAlnylam Pharmaceuticals, Inc.COM427,000$80.6M2.1%+232,000+119.0%AddedHistory
LLYEli Lilly & CoStock330,000$76.2M1.9%−235,500−41.6%ReducedHistory
NUVBNuvation Bio Inc.COM CL A7,263,488$72.2M1.8%+297,112+4.3%AddedHistory
NTRANatera, Inc.COM638,700$71.2M1.8%+202,700+46.5%AddedHistory
HOLXHologic IncCOM945,400$69.8M1.8%−263,400−21.8%ReducedHistory
BAXBaxter International IncStock862,000$69.3M1.8%+862,000NewHistory
ARNAArena Pharmaceuticals IncCOM NEW1,139,000$67.8M1.7%+196,000+20.8%AddedHistory
ISEEIVERIC bio, Inc.COM4,100,000$66.6M1.7%+2,699,990+192.9%AddedHistory
UTHRUnited Therapeutics CorpCOM351,000$64.8M1.7%+114,600+48.5%AddedHistory
STVNStevanato Group S.p.A.ORD SHS2,541,893$64.3M1.6%+2,541,893NewHistory
SHCSotera Health CoCOM2,378,000$62.2M1.6%+468,000+24.5%AddedHistory
IDYAIDEAYA Biosciences, Inc.COM2,437,000$62.1M1.6%+367,000+17.7%AddedHistory
CRBUCaribou Biosciences, Inc.COM2,474,067$59.1M1.5%+2,474,067NewHistory
CTLTCatalent, Inc.COM398,000$53.0M1.4%−142,000−26.3%ReducedHistory
GRTSGritstone bio, Inc.COM4,457,831$48.1M1.2%+2,335,767+110.1%AddedHistory
LEGNLegend Biotech CorpSPONSORED ADS894,000$45.2M1.2%+269,000+43.0%AddedHistory
OCDXOrtho Clinical Diagnostics Holdings plcORD SHS2,398,000$44.3M1.1%+2,398,000NewHistory
PFEPfizer IncStock1,026,800$44.2M1.1%+1,026,800NewHistory
ARWRArrowhead Pharmaceuticals, Inc.COM673,700$42.1M1.1%+569,700+547.8%AddedHistory
STTKShattuck Labs, Inc.COM2,025,000$41.3M1.1%+84,800+4.4%AddedHistory
RAREUltragenyx Pharmaceutical Inc.COM455,000$41.0M1.0%+455,000NewHistory
IMCRImmunocore Holdings plcADS1,095,600$40.6M1.0%+494,600+82.3%AddedHistory
Avidity Biosciences, Inc.05370A108COM1,645,000$40.5M1.0%+1,645,000New–
IOVAIovance Biotherapeutics, Inc.COM1,462,200$36.1M0.9%+1,462,200NewHistory
INSMINSMED IncCOM PAR $.011,292,000$35.6M0.9%+141,950+12.3%AddedHistory
EXASExact Sciences CorpCOM369,000$35.2M0.9%−221,000−37.5%ReducedHistory
CMPSCOMPASS Pathways plcSPONSORED ADS1,162,000$34.7M0.9%+162,000+16.2%AddedHistory
ATECAlphatec Holdings, Inc.COM NEW2,786,000$34.0M0.9%+165,000+6.3%AddedHistory
NTLAIntellia Therapeutics, Inc.COM251,000$33.7M0.9%−129,000−33.9%ReducedHistory
NBPNovaBridge BiosciencesSPONSORED ADS454,000$32.9M0.8%−275,000−37.7%ReducedHistory
SPNESeaSpine Holdings CorpCOM1,943,000$30.6M0.8%+418,002+27.4%AddedHistory
Bellus Health Inc New07987C204COM NEW4,942,000$30.3M0.8%+692,000+16.3%Added–
KYMRKymera Therapeutics, Inc.COM514,500$30.2M0.8%+514,500NewHistory
CYTCyteir Therapeutics, Inc.COM1,683,441$29.5M0.8%−124,953−6.9%ReducedHistory
ALTAltimmune, Inc.COM NEW2,167,900$24.5M0.6%+2,167,900NewHistory
VIRVir Biotechnology, Inc.COM515,000$22.4M0.6%+353,000+217.9%AddedHistory
ALPNAlpine Immune Sciences, Inc.COM1,932,000$20.6M0.5%+437,000+29.2%AddedHistory
EPIXESSA Pharma Inc.COM NEW2,450,000$19.6M0.5%−300,000−10.9%ReducedHistory
ACETAdicet Bio, Inc.COM2,419,600$19.0M0.5%+169,100+7.5%AddedHistory
IPSCCentury Therapeutics, Inc.COM739,269$18.6M0.5%−264,253−26.3%ReducedHistory
SIBNSI-BONE, Inc.COM831,200$17.8M0.5%+256,200+44.6%AddedHistory
SANASana Biotechnology, Inc.COM774,644$17.4M0.4%−3,953−0.5%ReducedHistory
PATHUiPath, Inc.Stock319,000$16.8M0.4%+19,000+6.3%AddedHistory
Field Trip Health Ord31656R102COM3,581,000$16.4M0.4%+3,581,000New–
LFSTLifeStance Health Group, Inc.COM1,000,000$14.5M0.4%−100,000−9.1%ReducedHistory
PHASPhaseBio Pharmaceuticals IncCOM4,405,000$13.7M0.3%+90,000+2.1%AddedHistory
WGSGeneDx Holdings Corp.COMMON STOCK1,660,000$12.6M0.3%+1,660,000NewHistory
GHRSGH Research PLCORDINARY SHARES560,000$12.4M0.3%00.0%UnchangedHistory
LENZLENZ Therapeutics, Inc.COM748,995$12.3M0.3%+13,495+1.8%AddedHistory
ACIUAC Immune SASHS1,739,600$11.7M0.3%+155,600+9.8%AddedHistory
SCYXScynexis IncCOM NEW2,060,000$10.9M0.3%00.0%UnchangedHistory
HOWLWerewolf Therapeutics, Inc.COM625,120$10.7M0.3%−25,145−3.9%ReducedHistory
SSentinelOne, Inc.CL A200,000$10.7M0.3%00.0%UnchangedHistory
HARPHarpoon Therapeutics, Inc.COM1,190,600$9.41M0.2%−309,400−20.6%ReducedHistory
ESMTEngageSmart, Inc.COMMON STOCK275,000$9.37M0.2%+275,000NewHistory
ACADAcadia Pharmaceuticals IncCOM550,000$9.14M0.2%−390,000−41.5%ReducedHistory
ORTXOrchard Therapeutics plcADS3,836,798$8.82M0.2%+55,000+1.5%AddedHistory
CMAXCareMax, Inc.COM CL A827,402$7.99M0.2%+10,000+1.2%AddedHistory
ZETAZeta Global Holdings Corp.CL A1,300,000$7.62M0.2%00.0%UnchangedHistory
TILInstil Bio, Inc.COM408,140$7.30M0.2%+8,140+2.0%AddedHistory
GLUEMonte Rosa Therapeutics, Inc.COM300,000$6.68M0.2%00.0%UnchangedHistory
ONCSOncosec Medical IncCOM2,945,000$6.27M0.2%+145,000+5.2%AddedHistory
TRMLTourmaline Bio, Inc.COM455,000$6.17M0.2%+18,637+4.3%AddedHistory
XLRNAcceleron Pharma IncCOM35,000$6.02M0.2%−323,500−90.2%ReducedHistory
KROSKeros Therapeutics, Inc.COM145,100$5.74M0.1%+145,100NewHistory
TCRTAlaunos Therapeutics, Inc.COM3,000,000$5.46M0.1%+3,000,000NewHistory
Medicus Sciences AcquisitionG5960S108CL A SHS520,000$5.07M0.1%00.0%Unchanged–
ARYDARYA Sciences Acquisition Corp IVCL A500,000$5.03M0.1%00.0%UnchangedHistory
BCLS Acquisition CorpG0904B105COM CL A500,000$4.98M0.1%00.0%Unchanged–
Dynamics Special Purpose Cor268010105CLASS A COM500,000$4.97M0.1%00.0%Unchanged–
HYPRHyperfine, Inc.CL A SHS500,000$4.95M0.1%00.0%UnchangedHistory
Panacea Acquisition Corp. IIG6882C106CL A SHS500,000$4.88M0.1%00.0%Unchanged–
SLGCSomaLogic, Inc.CLASS A COM330,000$4.09M0.1%+330,000NewHistory
OBIOOrchestra BioMed Holdings, Inc.ORD SHS400,000$3.96M0.1%00.0%UnchangedHistory
MLTXMoonLake ImmunotherapeuticsCOM CL A400,000$3.94M0.1%00.0%UnchangedHistory
SNCEScience 37 Holdings, Inc.COM400,000$3.92M0.1%00.0%UnchangedHistory
TNGXTango Therapeutics, Inc.COM300,000$3.88M0.1%+300,000NewHistory
ZLABZai Lab LtdADR35,600$3.75M0.1%−64,400−64.4%ReducedHistory
NAUTNautilus Biotechnology, Inc.COM600,000$3.68M0.1%−525,000−46.7%ReducedHistory
SGHTSight Sciences, Inc.COM145,189$3.30M0.1%+145,189NewHistory
ATAIAtai Beckley N.V.SHS218,730$3.23M0.1%−132,257−37.7%ReducedHistory
KZRKezar Life Sciences, Inc.COM260,000$2.25M0.1%+260,000NewHistory
AKLIAkili, Inc.CLASS A ORD SHS200,000$1.99M0.1%00.0%UnchangedHistory
DNABSocial Capital Suvretta Holdings Corp. IICLASS A ORD SHS200,000$1.98M0.1%00.0%UnchangedHistory
DNADSocial Capital Suvretta Holdings Corp. IVCLASS A ORD SHS200,000$1.96M0.1%00.0%UnchangedHistory
PROKProkidney Corp.CLASS A ORD SHS200,000$1.96M<0.1%00.0%UnchangedHistory

Options (2)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Avidity Partners Management LP in Q3 2021
SecurityClassPutsCalls
State Street SPDR S&P Biotech ETF78464A870ETF–$379.8M
XLRNAcceleron Pharma IncCOM–$211.4M

Sold out since Q2 2021 (31)

Positions held at the end of Q2 2021 that are gone from this filing.

Positions of Avidity Partners Management LP sold out since Q2 2021
SecurityClassShares in Q2 2021Value in Q2 2021% of portfolio in Q2 2021History
MRVIMaravai Lifesciences Holdings, Inc.COM CL A2,963,545$123.7M3.3%History
MDTMedtronic plcStock535,000$66.4M1.8%History
BIIBBiogen Inc.COM183,900$63.7M1.7%History
NEONeogenomics IncCOM NEW1,367,000$61.7M1.7%History
CNCCentene CorpStock751,200$54.8M1.5%History
BBIOBridgeBio Pharma, Inc.COM673,400$41.0M1.1%History
Trillium Therapeutics Inc.89620X506COM NEW4,105,000$39.8M1.1%–
CAHCardinal Health IncStock654,200$37.3M1.0%History
KDMNKadmon Holdings, Inc.COM9,294,600$36.0M1.0%History
DVAXDynavax Technologies CorpCOM NEW3,400,000$33.5M0.9%History
ALDXAldeyra Therapeutics, Inc.COM1,450,000$16.4M0.4%History
SYNHSyneos Health, Inc.CL A175,000$15.7M0.4%History
PRTAProthena Corp Public Ltd CoSHS182,000$9.36M0.3%History
CRDFCardiff Oncology, Inc.COM1,395,000$9.28M0.3%History
MNDYmonday.com Ltd.SHS40,000$8.94M0.2%History
DOCSDoximity, Inc.CL A150,000$8.73M0.2%History
ESPREsperion Therapeutics, Inc.COM400,000$8.46M0.2%History
PHVSPharvaris N.V.COM400,000$7.45M0.2%History
CM Life Sciences Inc18978W109COM CL A525,000$7.36M0.2%–
DNLIDenali Therapeutics Inc.COM86,100$6.75M0.2%History
FIGSFIGS, Inc.CL A100,000$5.01M0.1%History
CELCCelcuity Inc.COM200,000$4.80M0.1%History
CFLTConfluent, Inc.CLASS A COM100,000$4.75M0.1%History
CM Life Sciences II Inc125842203UNIT 02/25/2028330,000$4.44M0.1%–
Walkme LtdM97628107ORD SHS150,000$4.39M0.1%–
BCTG Acquisition Corp05492W103COM300,000$3.41M0.1%–
TKNOAlpha Teknova, Inc.COM100,000$2.37M0.1%History
FLYWFlywire CorpCOM VTG50,000$1.84M<0.1%History
CLVSClovis Oncology, Inc.COM271,726$1.58M<0.1%History
OMICSingular Genomics Systems, Inc.COM50,000$1.37M<0.1%History
NPCENeuroPace IncCOM40,000$952.0K<0.1%History