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Livermore
Livermore
ZHEN

Ikarian Capital, LLC

SEC CIK
0001778253
Latest filing
Aug 14, 2026

Holdings in Q2 2021

Holdings as of Jun 30, 2021, filed Aug 18, 2021. Long positions only; changes compare share counts with Q1 2021.

Institution overview
Positions
153
−25 vs. Q1 2021
Portfolio value
$559.8M
−$111.9M (−16.7%) vs. Q1 2021
Filed
Aug 18, 2021
AmendedSEC
Holdings of Ikarian Capital, LLC in Q2 2021
SecurityClassSharesValue% of portfolioShare changeActionHistory
BIIBBiogen Inc.COM125,962$43.6M7.8%+120,262+2,109.9%AddedHistory
CRSPCRISPR Therapeutics AGNAMEN AKT119,711$19.4M3.5%+104,627+693.6%AddedHistory
XFORX4 Pharmaceuticals, IncCOM2,719,290$17.7M3.2%+104,302+4.0%AddedHistory
TCONTracon Pharmaceuticals, Inc.COM NEW2,716,840$17.6M3.1%00.0%UnchangedHistory
ALECAlector, Inc.COM674,723$14.1M2.5%+417,223+162.0%AddedHistory
LKFTLakefront Biotherapeutics NVSPON ADR200,000$13.9M2.5%00.0%UnchangedHistory
CMRXChimerix IncCOM1,575,916$12.6M2.3%−21,598−1.4%ReducedHistory
MGNXMacrogenics IncCOM459,602$12.3M2.2%−40,867−8.2%ReducedHistory
CLDXCelldex Therapeutics, Inc.COM NEW365,544$12.2M2.2%−230,746−38.7%ReducedHistory
XENEXenon Pharmaceuticals Inc.COM640,606$11.9M2.1%+300.0%AddedHistory
MISTMilestone Pharmaceuticals Inc.COM1,980,400$10.9M1.9%+143,855+7.8%AddedHistory
SRRASierra Oncology, Inc.COM NEW545,002$10.6M1.9%+99,814+22.4%AddedHistory
PCVXVaxcyte, Inc.COM448,110$10.1M1.8%−53,000−10.6%ReducedHistory
RLMDRelmada Therapeutics, Inc.COM300,207$9.61M1.7%+10,000+3.4%AddedHistory
ITCIIntra-Cellular Therapies, Inc.COM230,889$9.43M1.7%−100,100−30.2%ReducedHistory
AUTLAutolus Therapeutics plcSPON ADS1,356,048$9.00M1.6%+100,000+8.0%AddedHistory
ANVSAnnovis Bio, Inc.COM103,527$8.86M1.6%−89,841−46.5%ReducedHistory
GOSSGossamer Bio, Inc.COM1,048,383$8.51M1.5%00.0%UnchangedHistory
CABACabaletta Bio, Inc.COM947,128$8.14M1.5%+557,744+143.2%AddedHistory
CGEMCullinan Therapeutics, Inc.COM295,596$7.61M1.4%+294,596+29,459.6%AddedHistory
ODTOdonate Therapeutics, Inc.COM1,986,412$6.93M1.2%+650,000+48.6%AddedHistory
SCPHscPharmaceuticals Inc.COM1,095,024$6.69M1.2%−213,675−16.3%ReducedHistory
CLVSClovis Oncology, Inc.COM1,129,473$6.55M1.2%+450,000+66.2%AddedHistory
ChemoCentryx, Inc.16383L106COM471,376$6.31M1.1%+471,376New–
OCULOcular Therapeutix, IncCOM419,573$5.95M1.1%00.0%UnchangedHistory
TARAProtara Therapeutics, Inc.COM STK584,804$5.70M1.0%−64,738−10.0%ReducedHistory
VSTMVerastem, Inc.COM1,394,394$5.67M1.0%−1,300,000−48.2%ReducedHistory
VINCVincerx Pharma, Inc.COM NEW426,743$5.54M1.0%−11,941−2.7%ReducedHistory
CMMBChemomab Therapeutics Ltd.SPONSORED ADS290,534$5.53M1.0%+290,534NewHistory
STTKShattuck Labs, Inc.COM190,330$5.52M1.0%00.0%UnchangedHistory
HZNPHorizon Therapeutics Public Ltd CoSHS54,815$5.13M0.9%+54,212+8,990.4%AddedHistory
ACADAcadia Pharmaceuticals IncCOM209,866$5.12M0.9%+203,858+3,393.1%AddedHistory
LYRALyra Therapeutics, Inc.COM624,684$5.02M0.9%−156,044−20.0%ReducedHistory
FNCHFinch Therapeutics Group, Inc.COM325,000$4.57M0.8%+175,000+116.7%AddedHistory
IOVAIovance Biotherapeutics, Inc.COM175,000$4.55M0.8%+175,000NewHistory
STSASatsuma Pharmaceuticals, Inc.COM644,056$4.54M0.8%−32,238−4.8%ReducedHistory
OVIDOvid Therapeutics Inc.COM1,124,872$4.40M0.8%00.0%UnchangedHistory
Chardan Healthcr Acqstn 2 Co15957T206UNIT 99/99/9999400,000$4.37M0.8%00.0%Unchanged–
NXTCNextCure, Inc.COM516,870$4.15M0.7%+62,918+13.9%AddedHistory
NBPNovaBridge BiosciencesSPONSORED ADS46,066$3.87M0.7%−203,934−81.6%ReducedHistory
ARK ETF Tr00214Q302GENOMIC REV ETF40,961$3.79M0.7%+38,961+1,948.1%Added–
RDNTRadNet, Inc.COM110,647$3.73M0.7%+110,647NewHistory
KDMNKadmon Holdings, Inc.COM936,615$3.63M0.6%00.0%UnchangedHistory
DBVTDBV Technologies S.A.SPONSORED ADR322,730$3.55M0.6%00.0%UnchangedHistory
RNTXRein Therapeutics, Inc.COM2,800,000$3.50M0.6%00.0%UnchangedHistory
PHATPhathom Pharmaceuticals, Inc.COM100,000$3.39M0.6%00.0%UnchangedHistory
TCDATricida, Inc.COM775,294$3.35M0.6%00.0%UnchangedHistory
SYBXSynlogic, Inc.COM848,354$3.30M0.6%−644,260−43.2%ReducedHistory
FOLDAmicus Therapeutics, Inc.COM341,500$3.29M0.6%00.0%UnchangedHistory
CMPSCOMPASS Pathways plcSPONSORED ADS85,063$3.25M0.6%−140,863−62.3%ReducedHistory
PLRXPliant Therapeutics, Inc.COM108,700$3.17M0.6%00.0%UnchangedHistory
VKTXViking Therapeutics, Inc.COM524,754$3.14M0.6%−200,000−27.6%ReducedHistory
Bellus Health Inc New07987C204COM NEW1,010,545$3.14M0.6%+610,545+152.6%Added–
INCYIncyte CorpCOM36,533$3.07M0.5%+13,521+58.8%AddedHistory
BCABBioAtla, Inc.COM70,160$2.97M0.5%00.0%UnchangedHistory
TAOXTAO Synergies Inc.COM NEW300,000$2.96M0.5%+300,000NewHistory
AVTXAvalo Therapeutics, Inc.COM897,330$2.93M0.5%00.0%UnchangedHistory
VTGNVistagen Therapeutics, Inc.COM NEW916,552$2.89M0.5%−1,969,400−68.2%ReducedHistory
ASNDAscendis Pharma A/SSPONSORED ADR21,825$2.87M0.5%−40,265−64.8%ReducedHistory
WHWKWhitehawk Therapeutics, Inc.COM1,676,093$2.83M0.5%−975,000−36.8%ReducedHistory
CM Life Sciences Inc18978W109COM CL A200,000$2.80M0.5%+200,000New–
ELDNEledon Pharmaceuticals, Inc.COM350,000$2.77M0.5%+100,000+40.0%AddedHistory
IRONDisc Medicine, Inc.COM426,455$2.76M0.5%−257,924−37.7%ReducedHistory
ALLKAllakos Inc.COM31,700$2.71M0.5%00.0%UnchangedHistory
ALPNAlpine Immune Sciences, Inc.COM300,454$2.70M0.5%−4,285−1.4%ReducedHistory
HEPAHepion Pharmaceuticals, Inc.COM1,365,059$2.70M0.5%+1,365,059NewHistory
SVRASavara IncCOM1,586,737$2.70M0.5%−127,629−7.4%ReducedHistory
IMTXImmatics N.V.SHS225,138$2.61M0.5%−30,000−11.8%ReducedHistory
INMBInmune Bio, Inc.COM146,883$2.58M0.5%−86,693−37.1%ReducedHistory
KAKineta, Inc.COM219,470$2.56M0.5%00.0%UnchangedHistory
LQDALiquidia CorpCOM NEW890,435$2.55M0.5%−60,965−6.4%ReducedHistory
GYREGyre Therapeutics, Inc.COM NEW581,200$2.52M0.4%00.0%UnchangedHistory
STROSutro Biopharma, Inc.COM135,360$2.52M0.4%00.0%UnchangedHistory
SLDBSolid Biosciences Inc.COM675,675$2.47M0.4%+652,058+2,761.0%AddedHistory
CYTKCytokinetics IncCOM NEW120,895$2.39M0.4%−6,105−4.8%ReducedHistory
KALVKalVista Pharmaceuticals, Inc.COM96,965$2.32M0.4%−200,000−67.3%ReducedHistory
MDGLMadrigal Pharmaceuticals, Inc.COM23,654$2.30M0.4%00.0%UnchangedHistory
ICADIcad IncCOM NEW128,137$2.22M0.4%−89,500−41.1%ReducedHistory
ZGNXZogenix, Inc.COM NEW124,091$2.14M0.4%00.0%UnchangedHistory
BCELAtreca, Inc.CL A COM250,000$2.13M0.4%+250,000NewHistory
OBIOOrchestra BioMed Holdings, Inc.ORD SHS200,000$2.04M0.4%00.0%UnchangedHistory
KRSAKorsana Biosciences, Inc.COM509,924$1.99M0.4%+209,924+70.0%AddedHistory
IFRXInflaRx N.V.COM666,596$1.98M0.4%−33,154−4.7%ReducedHistory
CASICASI Pharmaceuticals, Inc (DE)COM1,268,154$1.97M0.4%00.0%UnchangedHistory
QSIQuantum-Si IncCOM CL A160,000$1.96M0.4%+160,000NewHistory
IMVTImmunovant, Inc.COM185,500$1.96M0.4%+185,500NewHistory
PASGPassage BIO, Inc.COM145,858$1.93M0.3%00.0%UnchangedHistory
NTBLNotable Labs, Ltd.COM800,811$1.92M0.3%00.0%UnchangedHistory
BDTXBlack Diamond Therapeutics, Inc.COM153,941$1.88M0.3%00.0%UnchangedHistory
DMACDiaMedica Therapeutics Inc.COM NEW415,000$1.85M0.3%00.0%UnchangedHistory
CRBPCorbus Pharmaceuticals Holdings, Inc.COM964,100$1.76M0.3%00.0%UnchangedHistory
MBIOMustang Bio, Inc.COM526,003$1.75M0.3%00.0%UnchangedHistory
FULCFulcrum Therapeutics, Inc.COM162,700$1.71M0.3%−264,039−61.9%ReducedHistory
Bellicum Pharmaceuticals, Inc079481404COM NEW500,000$1.65M0.3%00.0%Unchanged–
AGTCApplied Genetic Technologies CorpCOM415,884$1.63M0.3%00.0%UnchangedHistory
ACRSAclaris Therapeutics, Inc.COM89,788$1.58M0.3%−98,412−52.3%ReducedHistory
HARPHarpoon Therapeutics, Inc.COM113,600$1.58M0.3%−155,000−57.7%ReducedHistory
ACIUAC Immune SASHS196,208$1.56M0.3%+76,405+63.8%AddedHistory
ATYRaTYR PHARMA INCCOM NEW300,000$1.47M0.3%00.0%UnchangedHistory
Auris Medical Holding LtdG07025201SHS404,588$1.45M0.3%−56,934−12.3%Reduced–

Options (47)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Ikarian Capital, LLC in Q2 2021
SecurityClassPutsCalls
BIIBBiogen Inc.COM–$93.5M
ALNYAlnylam Pharmaceuticals, Inc.COM$50.9M$33.2M
NTLAIntellia Therapeutics, Inc.COM–$47.7M
APLSApellis Pharmaceuticals, Inc.COM$19.0M$19.0M
CRSPCRISPR Therapeutics AGNAMEN AKT$32.4M–
FLNAFilana Therapeutics, Inc.COM–$31.2M
SAGESage Therapeutics, Inc.COM$14.2M$14.4M
RETAReata Pharmaceuticals IncCL A$24.8M–
BHCBausch Health Companies Inc.Stock$7.33M$16.1M
HZNPHorizon Therapeutics Public Ltd CoSHS–$23.4M
CLDXCelldex Therapeutics, Inc.COM NEW$535.0K$20.1M
INCYIncyte CorpCOM–$16.8M
ChemoCentryx, Inc.16383L106COM$13.0M$2.96M
ZGNXZogenix, Inc.COM NEW–$14.7M
MCRBSeres Therapeutics, Inc.COM–$11.9M
KYNBKyntra Bio, Inc.COM$5.16M$6.66M
RAPTRAPT Therapeutics, Inc.COM$11.1M–
ARK ETF Tr00214Q302GENOMIC REV ETF$11.1M–
ARNAArena Pharmaceuticals IncCOM NEW–$10.2M
ALLKAllakos Inc.COM$3.22M$6.96M
OCULOcular Therapeutix, IncCOM–$9.93M
FATEFate Therapeutics IncCOM$8.68M–
ITCIIntra-Cellular Therapies, Inc.COM–$8.57M
MGNXMacrogenics IncCOM–$8.06M
ADCTADC Therapeutics SASHS–$7.30M
LKFTLakefront Biotherapeutics NVSPON ADR–$6.89M
RCUSArcus Biosciences, Inc.COM$6.74M–
KODKodiak Sciences Inc.COM–$6.72M
RLMDRelmada Therapeutics, Inc.COM–$6.51M
GILDGilead Sciences, Inc.Stock–$5.51M
IOVAIovance Biotherapeutics, Inc.COM$5.20M–
IMVTImmunovant, Inc.COM$610.0K$4.23M
U.S. Global Jets ETF26922A842ETF–$4.84M
SRPTSarepta Therapeutics, Inc.COM–$3.89M
TGTXTG Therapeutics, Inc.COM$3.88M–
XENEXenon Pharmaceuticals Inc.COM–$3.33M
ALLOAllogene Therapeutics, Inc.COM–$2.61M
CVMCel Sci CorpCOM PAR NEW–$2.60M
Trillium Therapeutics Inc.89620X506COM NEW–$1.94M
EYPTEyePoint, Inc.COM NEW–$1.88M
ABCLAbCellera Biologics Inc.COM–$1.62M
ASNDAscendis Pharma A/SSPONSORED ADR–$1.13M
KRROKorro Bio, Inc.COM$1.00M–
ALECAlector, Inc.COM$465.0K$465.0K
STOKStoke Therapeutics, Inc.COM$606.0K–
VCELVericel CorpCOM–$416.0K
ZLABZai Lab LtdADR–$284.0K

Sold out since Q1 2021 (43)

Positions held at the end of Q1 2021 that are gone from this filing.

Positions of Ikarian Capital, LLC sold out since Q1 2021
SecurityClassShares in Q1 2021Value in Q1 2021% of portfolio in Q1 2021History
CRISCuris IncCOM NEW1,220,356$13.8M2.1%History
PRTAProthena Corp Public Ltd CoSHS437,430$11.0M1.6%History
EPIXESSA Pharma Inc.COM NEW264,868$7.69M1.1%History
MCRBSeres Therapeutics, Inc.COM350,000$7.21M1.1%History
SAGESage Therapeutics, Inc.COM91,151$6.82M1.0%History
ARDXArdelyx, Inc.COM1,030,436$6.82M1.0%History
SNCEScience 37 Holdings, Inc.COM512,450$5.20M0.8%History
SRRKScholar Rock Holding CorpCOM67,059$3.40M0.5%History
BCTG Acquisition Corp05492W103COM300,250$3.34M0.5%–
ACHVAchieve Life Sciences, Inc.COM284,151$3.29M0.5%History
SBBPStrongbridge Biopharma plcSHS USD1,160,450$3.20M0.5%History
MORFMorphic Holding, Inc.COM49,925$3.16M0.5%History
Highcape Cap Acquisition Cor42984L105COM CL A260,000$3.10M0.5%–
TCRRTCR2 Therapeutics Inc.COM136,486$3.01M0.4%History
NUVBNuvation Bio Inc.COM CL A250,000$2.61M0.4%History
ALTAltimmune, Inc.COM NEW181,941$2.57M0.4%History
ZLABZai Lab LtdADR17,000$2.25M0.3%History
PDSBPDS Biotechnology CorpCOM383,373$1.75M0.3%History
Millendo Therapeutics Inc60040X103COM1,348,021$1.62M0.2%–
VIRXViracta Therapeutics, Inc.COM155,599$1.44M0.2%History
SRNESorrento Therapeutics, Inc.COM NEW165,900$1.37M0.2%History
RUBYRubius Therapeutics, Inc.COM50,000$1.33M0.2%History
Onconova Therapeutics Inc68232V405COM PAR1,145,426$1.14M0.2%–
KNSAKiniksa Pharmaceuticals International, plcCOM CL A51,273$949.0K0.1%History
SNDXSyndax Pharmaceuticals IncCOM40,913$914.0K0.1%History
CEMIChembio Diagnostics, Inc.COM NEW219,109$769.0K0.1%History
CLOVClover Health Investments, Corp.COM CL A100,000$757.0K0.1%History
SYRSSyros Pharmaceuticals, Inc.COM100,000$748.0K0.1%History
ALBOAlbireo Pharma, Inc.COM16,883$595.0K0.1%History
ARVNArvinas, Inc.COM8,430$558.0K0.1%History
KURAKura Oncology, Inc.COM15,603$441.0K0.1%History
SLSSELLAS Life Sciences Group, Inc.COM NEW48,053$410.0K0.1%History
ABUSArbutus Biopharma CorpCOM115,000$383.0K0.1%History
BTAIQBioXcel Therapeutics, Inc.COM5,232$226.0K<0.1%History
ARNAArena Pharmaceuticals IncCOM NEW2,200$153.0K<0.1%History
CYRXCryoport, Inc.COM PAR $0.0012,900$151.0K<0.1%History
KNTEKinnate Biopharma Inc.COM2,000$62.0K<0.1%History
RCKTRocket Pharmaceuticals, Inc.COM1,400$61.0K<0.1%History
RETAReata Pharmaceuticals IncCL A600$60.0K<0.1%History
IGMSIGM Biosciences, Inc.COM300$23.0K<0.1%History
SRPTSarepta Therapeutics, Inc.COM134$10.0K<0.1%History
KPTIKaryopharm Therapeutics Inc.COM791$9.00K<0.1%History
BLUEbluebird bio, Inc.COM281$8.00K<0.1%History