Baker Bros. Advisors LP
- SEC CIK
- 0001263508
- Latest filing
- Aug 14, 2026
Holdings in Q4 2021
Holdings as of Dec 31, 2021, filed Feb 14, 2022. Long positions only; changes compare share counts with Q3 2021.
- Positions
- 121
- −1 vs. Q3 2021
- Portfolio value
- $20.6B
- −$2.22B (−9.7%) vs. Q3 2021
| Security | Class | Shares | Value | % of portfolio | Share change | Action | History |
|---|---|---|---|---|---|---|---|
| Bellicum Pharmaceuticals, Inc079481404 | COM NEW | 249,123 | $371.0K | <0.1% | 00.0% | Unchanged | – |
| INZYInozyme Pharma, Inc. | COM | 106,999 | $730.0K | <0.1% | 00.0% | Unchanged | History |
| PASGPassage BIO, Inc. | COM | 117,161 | $744.0K | <0.1% | 00.0% | Unchanged | History |
| Surrozen, Inc.86889P117 | *W EXP 08/01/203 | 833,333 | $958.0K | <0.1% | 00.0% | Unchanged | – |
| EVFMEvofem Biosciences, Inc. | COM | 2,697,110 | $1.01M | <0.1% | 00.0% | Unchanged | History |
| FHTXFoghorn Therapeutics Inc. | COM | 45,027 | $1.03M | <0.1% | +45,027 | New | History |
| LogicBio Therapeutics, Inc.54142F102 | COM | 451,478 | $1.04M | <0.1% | 00.0% | Unchanged | – |
| OYSTOyster Point Pharma, Inc. | COM | 61,424 | $1.12M | <0.1% | 00.0% | Unchanged | History |
| TARAProtara Therapeutics, Inc. | COM STK | 199,671 | $1.35M | <0.1% | 00.0% | Unchanged | History |
| NEXINexImmune, Inc. | COM | 294,117 | $1.36M | <0.1% | 00.0% | Unchanged | History |
| SERASera Prognostics, Inc. | CLASS A COM | 201,562 | $1.39M | <0.1% | 00.0% | Unchanged | History |
| GMDAGamida Cell Ltd. | SHS | 610,626 | $1.55M | <0.1% | 00.0% | Unchanged | History |
| HOOKHOOKIPA Pharma Inc. | COM | 700,481 | $1.63M | <0.1% | 00.0% | Unchanged | History |
| CYPHCypherpunk Technologies Inc. | COM | 559,705 | $1.81M | <0.1% | 00.0% | Unchanged | History |
| BNRBurning Rock Biotech Ltd | SPONSORED ADS | 209,131 | $1.99M | <0.1% | 00.0% | Unchanged | History |
| KZRKezar Life Sciences, Inc. | COM | 139,676 | $2.33M | <0.1% | 00.0% | Unchanged | History |
| SNDXSyndax Pharmaceuticals Inc | COM | 110,729 | $2.42M | <0.1% | 00.0% | Unchanged | History |
| ALBOAlbireo Pharma, Inc. | COM | 104,521 | $2.43M | <0.1% | −307,945−74.7% | Reduced | History |
| VINCVincerx Pharma, Inc. | COM NEW | 241,379 | $2.46M | <0.1% | 00.0% | Unchanged | History |
| AKROAkero Therapeutics, Inc. | COM | 118,378 | $2.50M | <0.1% | 00.0% | Unchanged | History |
| CABACabaletta Bio, Inc. | COM | 662,063 | $2.51M | <0.1% | 00.0% | Unchanged | History |
| Genetron Hldgs Ltd37186H100 | ADS | 455,306 | $2.78M | <0.1% | 00.0% | Unchanged | – |
| TCRRTCR2 Therapeutics Inc. | COM | 753,064 | $3.51M | <0.1% | +576,603+326.8% | Added | History |
| BMEABiomea Fusion, Inc. | COM | 524,617 | $3.91M | <0.1% | 00.0% | Unchanged | History |
| DNLIDenali Therapeutics Inc. | COM | 88,738 | $3.96M | <0.1% | 00.0% | Unchanged | History |
| KURAKura Oncology, Inc. | COM | 304,158 | $4.26M | <0.1% | 00.0% | Unchanged | History |
| ATYRaTYR PHARMA INC | COM NEW | 625,000 | $4.67M | <0.1% | 00.0% | Unchanged | History |
| ALECAlector, Inc. | COM | 239,228 | $4.94M | <0.1% | 00.0% | Unchanged | History |
| NGMNGM Biopharmaceuticals Inc | COM | 291,801 | $5.17M | <0.1% | 00.0% | Unchanged | History |
| HRMYHarmony Biosciences Holdings, Inc. | COM | 123,600 | $5.27M | <0.1% | 00.0% | Unchanged | History |
| RVMDRevolution Medicines, Inc. | COM | 222,222 | $5.59M | <0.1% | 00.0% | Unchanged | History |
| RETAReata Pharmaceuticals Inc | CL A | 223,976 | $5.91M | <0.1% | 00.0% | Unchanged | History |
| TCRXTScan Therapeutics, Inc. | COM | 1,425,000 | $6.41M | <0.1% | 00.0% | Unchanged | History |
| ALLKAllakos Inc. | COM | 703,050 | $6.88M | <0.1% | 00.0% | Unchanged | History |
| NVAXNovavax Inc | COM NEW | 48,168 | $6.89M | <0.1% | −60,588−55.7% | Reduced | History |
| ITOSiTeos Therapeutics, Inc. | COM | 150,346 | $7.00M | <0.1% | 00.0% | Unchanged | History |
| MGNXMacrogenics Inc | COM | 442,579 | $7.10M | <0.1% | 00.0% | Unchanged | History |
| CBAYCymaBay Therapeutics, Inc. | COM | 2,170,464 | $7.34M | <0.1% | 00.0% | Unchanged | History |
| EWTXEdgewise Therapeutics, Inc. | COM | 500,000 | $7.64M | <0.1% | 00.0% | Unchanged | History |
| KYNBKyntra Bio, Inc. | COM | 580,150 | $8.18M | <0.1% | +580,150 | New | History |
| TNGXTango Therapeutics, Inc. | COM | 750,000 | $8.21M | <0.1% | 00.0% | Unchanged | History |
| KRTXKaruna Therapeutics, Inc. | COM | 69,966 | $9.17M | <0.1% | 00.0% | Unchanged | History |
| CYTCyteir Therapeutics, Inc. | COM | 812,640 | $9.24M | <0.1% | 00.0% | Unchanged | History |
| Invitae Corp46185LAB9 | NOTE 2.000% 9/0 | – | $9.62M | <0.1% | – | – | – |
| ALTAltimmune, Inc. | COM NEW | 1,072,038 | $9.82M | <0.1% | 00.0% | Unchanged | History |
| LONALeonaBio, Inc. | COM | 806,367 | $10.5M | 0.1% | 00.0% | Unchanged | History |
| BCELAtreca, Inc. | CL A COM | 3,532,760 | $10.7M | 0.1% | 00.0% | Unchanged | History |
| SRPTSarepta Therapeutics, Inc. | COM | 123,456 | $11.1M | 0.1% | +123,456 | New | History |
| RLMDRelmada Therapeutics, Inc. | COM | 495,113 | $11.2M | 0.1% | +294,117+146.3% | Added | History |
| TCDATricida, Inc. | COM | 1,285,014 | $12.3M | 0.1% | +247,582+23.9% | Added | History |
| CNTACentessa Pharmaceuticals plc | SPONSORED ADS | 1,127,273 | $12.7M | 0.1% | 00.0% | Unchanged | History |
| Achilles Therapeutics PLC00449L102 | SPONSORED ADS | 2,591,366 | $13.0M | 0.1% | 00.0% | Unchanged | – |
| Affimed N VN01045108 | COM | 2,653,169 | $14.6M | 0.1% | +2,488,564+1,511.8% | Added | – |
| Tricida, Inc.89610FAB7 | NOTE 3.500% 5/1 | – | $14.8M | 0.1% | – | – | – |
| ANABAnaptysbio, Inc | COM | 427,179 | $14.8M | 0.1% | 00.0% | Unchanged | History |
| DICEDICE Therapeutics, Inc. | COM | 588,235 | $14.9M | 0.1% | 00.0% | Unchanged | History |
| REPLReplimune Group, Inc. | COM | 593,395 | $16.1M | 0.1% | +439,883+286.5% | Added | History |
| SRZNSurrozen, Inc. | COM | 2,500,000 | $16.1M | 0.1% | 00.0% | Unchanged | History |
| BCABBioAtla, Inc. | COM | 825,000 | $16.2M | 0.1% | 00.0% | Unchanged | History |
| SYRESpyre Therapeutics, Inc. | COM | 3,410,106 | $16.2M | 0.1% | 00.0% | Unchanged | History |
| OTICOtonomy, Inc. | COM | 7,844,692 | $16.3M | 0.1% | +150,654+2.0% | Added | History |
| NGNENeurogene Inc. | COM | 3,821,740 | $18.4M | 0.1% | 00.0% | Unchanged | History |
| FLGTFulgent Genetics, Inc. | COM | 201,444 | $20.3M | 0.1% | −199,572−49.8% | Reduced | History |
| TSVT2seventy bio, Inc. | COMMON STOCK | 833,236 | $21.4M | 0.1% | +833,236 | New | History |
| JBIOJade Biosciences, Inc. | COM | 1,831,789 | $21.6M | 0.1% | +179,618+10.9% | Added | History |
| AXSMAxsome Therapeutics, Inc. | COM | 610,970 | $23.1M | 0.1% | +71,913+13.3% | Added | History |
| DBVTDBV Technologies S.A. | SPONSORED ADR | 14,614,264 | $23.4M | 0.1% | 00.0% | Unchanged | History |
| XENEXenon Pharmaceuticals Inc. | COM | 751,639 | $23.5M | 0.1% | 00.0% | Unchanged | History |
| CRNXCrinetics Pharmaceuticals, Inc. | COM | 827,480 | $23.5M | 0.1% | −93,176−10.1% | Reduced | History |
| CYVNYOpthea Ltd | SPONSORED ADS | 3,196,191 | $24.1M | 0.1% | −186,606−5.5% | Reduced | History |
| ALGSAligos Therapeutics, Inc. | COM | 2,076,400 | $24.6M | 0.1% | 00.0% | Unchanged | History |
| BLUEbluebird bio, Inc. | COM | 2,499,715 | $25.0M | 0.1% | 00.0% | Unchanged | History |
| ZYMEZymeworks Inc. | COM | 1,708,472 | $28.0M | 0.1% | 00.0% | Unchanged | History |
| FMTXForma Therapeutics Holdings, Inc. | SHS | 2,024,876 | $28.8M | 0.1% | 00.0% | Unchanged | History |
| TLISTalis Biomedical Corp | COM | 7,624,835 | $30.6M | 0.1% | +50,000+0.7% | Added | History |
| DSGNDesign Therapeutics, Inc. | COM | 1,436,636 | $30.8M | 0.1% | 00.0% | Unchanged | History |
| KNSAKiniksa Pharmaceuticals International, plc | COM CL A | 2,799,577 | $33.0M | 0.2% | 00.0% | Unchanged | History |
| ALKSAlkermes plc. | SHS | 1,500,000 | $34.9M | 0.2% | +271,830+22.1% | Added | History |
| ADAPYAdaptimmune Therapeutics PLC | SPONDS ADR | 9,830,877 | $36.9M | 0.2% | 00.0% | Unchanged | History |
| RAREUltragenyx Pharmaceutical Inc. | COM | 444,444 | $37.4M | 0.2% | 00.0% | Unchanged | History |
| KDNYChinook Therapeutics, Inc. | COM | 2,334,102 | $38.1M | 0.2% | +431,033+22.6% | Added | History |
| RYTMRhythm Pharmaceuticals, Inc. | COM | 3,863,239 | $38.6M | 0.2% | 00.0% | Unchanged | History |
| Sarepta Therapeutics, Inc.803607AB6 | DBCV 1.500%11/1 | – | $42.7M | 0.2% | – | – | – |
| INSMED Inc457669AB5 | NOTE 0.750% 6/0 | – | $43.3M | 0.2% | – | – | – |
| VSTMVerastem, Inc. | COM | 21,491,630 | $44.1M | 0.2% | 00.0% | Unchanged | History |
| Apellis Pharmaceuticals, Inc.03753UAB2 | NOTE 3.500% 9/1 | – | $48.0M | 0.2% | – | – | – |
| VERVVerve Therapeutics, Inc. | COM | 1,416,530 | $52.2M | 0.3% | 00.0% | Unchanged | History |
| KRYSKrystal Biotech, Inc. | COM | 807,735 | $56.5M | 0.3% | +200,000+32.9% | Added | History |
| NBIXNeurocrine Biosciences Inc | Stock | 676,975 | $57.7M | 0.3% | 00.0% | Unchanged | History |
| INSMINSMED Inc | COM PAR $.01 | 2,156,001 | $58.7M | 0.3% | 00.0% | Unchanged | History |
| ChemoCentryx, Inc.16383L106 | COM | 1,631,266 | $59.4M | 0.3% | +1,330,071+441.6% | Added | – |
| IMTXImmatics N.V. | SHS | 4,423,731 | $59.5M | 0.3% | 00.0% | Unchanged | History |
| HZNPHorizon Therapeutics Public Ltd Co | SHS | 599,110 | $64.6M | 0.3% | 00.0% | Unchanged | History |
| MRUSMerus N.V. | COM | 2,037,469 | $64.8M | 0.3% | 00.0% | Unchanged | History |
| TILInstil Bio, Inc. | COM | 3,893,700 | $66.6M | 0.3% | 00.0% | Unchanged | History |
| NRIXNurix Therapeutics, Inc. | COM | 2,454,082 | $71.0M | 0.3% | 00.0% | Unchanged | History |
| AMRNAmarin Corp PLC | SPONS ADR NEW | 21,169,805 | $71.3M | 0.3% | −686,227−3.1% | Reduced | History |
| HRTXHeron Therapeutics, Inc. | COM | 8,131,678 | $74.2M | 0.4% | 00.0% | Unchanged | History |
| TRDAEntrada Therapeutics, Inc. | COM | 4,704,419 | $80.5M | 0.4% | +4,704,419 | New | History |
| TVTXTravere Therapeutics, Inc. | COM | 2,669,054 | $82.8M | 0.4% | +629,282+30.9% | Added | History |
Sold out since Q3 2021 (6)
Positions held at the end of Q3 2021 that are gone from this filing.
| Security | Class | Shares in Q3 2021 | Value in Q3 2021 | % of portfolio in Q3 2021 | History |
|---|---|---|---|---|---|
| MIRMMirum Pharmaceuticals, Inc. | COM | 647,313 | $12.9M | 0.1% | History |
| AUPHAurinia Pharmaceuticals Inc. | COM | 520,523 | $11.5M | 0.1% | History |
| Amryt Pharma PLC03217L106 | SPONSORED ADS | 518,380 | $6.24M | <0.1% | – |
| Biomarin Pharmaceutical Inc09061GAH4 | NOTE 0.599% 8/0 | – | $4.61M | <0.1% | – |
| XLRNAcceleron Pharma Inc | COM | 22,430 | $3.86M | <0.1% | History |
| MREOMereo BioPharma Group plc | SPON ADS | 292,692 | $708.0K | <0.1% | History |