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Livermore
Livermore
ZHEN

OrbiMed Advisors LLC

SEC CIK
0001055951
Latest filing
Aug 14, 2026

Holdings in Q1 2022

Holdings as of Mar 31, 2022, filed May 16, 2022. Long positions only; changes compare share counts with Q4 2021.

Institution overview
Positions
141
−17 vs. Q4 2021
Portfolio value
$6.16B
−$1.55B (−20.1%) vs. Q4 2021
Filed
May 16, 2022
SEC
Holdings of OrbiMed Advisors LLC in Q1 2022
SecurityClassSharesValue% of portfolioShare changeActionHistory
Owlet, Inc.69120X115EQUITY WRT220,704$170.0K<0.1%00.0%Unchanged–
LABPLandos Biopharma, Inc.COM283,217$418.0K<0.1%00.0%UnchangedHistory
PYXSPyxis Oncology, Inc.COMMON STOCK143,640$580.0K<0.1%00.0%UnchangedHistory
MIRMMirum Pharmaceuticals, Inc.COM27,000$595.0K<0.1%+27,000NewHistory
LBPHLongboard Pharmaceuticals, Inc.COM113,500$606.0K<0.1%00.0%UnchangedHistory
Field Trip Health Ord31656R102COM576,930$762.0K<0.1%−961,540−62.5%Reduced–
CABACabaletta Bio, Inc.COM577,509$1.17M<0.1%+275,000+90.9%AddedHistory
APTXAptinyx Inc.COM538,500$1.22M<0.1%−211,000−28.2%ReducedHistory
Aslan Pharmaceuticals Ltd04522R101ADS1,941,219$1.75M<0.1%−28,781−1.5%Reduced–
Exscientia PLC30223G102ADS125,000$1.80M<0.1%00.0%Unchanged–
NBPNovaBridge BiosciencesSPONSORED ADS111,120$1.80M<0.1%00.0%UnchangedHistory
SGHTSight Sciences, Inc.COM200,000$2.31M<0.1%00.0%UnchangedHistory
XFORX4 Pharmaceuticals, IncCOM1,373,849$2.40M<0.1%00.0%UnchangedHistory
TRMLTourmaline Bio, Inc.COM247,240$2.43M<0.1%00.0%UnchangedHistory
VIGLVigil Neuroscience, Inc.COM411,191$2.89M<0.1%+411,191NewHistory
SRPTSarepta Therapeutics, Inc.COM39,100$3.05M<0.1%−19,600−33.4%ReducedHistory
AFIBAcutus Medical, Inc.COM2,648,386$3.68M0.1%00.0%UnchangedHistory
IMCRImmunocore Holdings plcADS128,100$3.83M0.1%+128,100NewHistory
TARAProtara Therapeutics, Inc.COM STK830,641$4.25M0.1%00.0%UnchangedHistory
Achilles Therapeutics PLC00449L102SPONSORED ADS1,584,845$4.66M0.1%00.0%Unchanged–
VORVor Biopharma Inc.COM833,333$5.03M0.1%00.0%UnchangedHistory
CALCCalciMedica, Inc.COM SHS4,163,347$5.12M0.1%00.0%UnchangedHistory
IMDXInsight Molecular Diagnostics Inc.COM3,493,800$5.21M0.1%00.0%UnchangedHistory
HLSQTessera Defense & Homeland Security Inc.COM2,813,489$5.43M0.1%00.0%UnchangedHistory
CTMXCytomX Therapeutics, Inc.COM2,124,975$5.67M0.1%−1,089,534−33.9%ReducedHistory
LogicBio Therapeutics, Inc.54142F102COM8,466,783$5.76M0.1%00.0%Unchanged–
ALBOAlbireo Pharma, Inc.COM194,000$5.79M0.1%+194,000NewHistory
Nanostring Technologies Inc63009RAD1NOTE 2.625% 5/0–$6.09M0.1%–––
NMTR9 Meters Biopharma, Inc.COM10,275,887$6.16M0.1%00.0%UnchangedHistory
DNTHDianthus Therapeutics, Inc.COM2,250,953$6.53M0.1%00.0%UnchangedHistory
SYRESpyre Therapeutics, Inc.COM2,956,124$6.80M0.1%00.0%UnchangedHistory
CGEMCullinan Therapeutics, Inc.COM670,787$7.02M0.1%−134,254−16.7%ReducedHistory
SONXSonendo, Inc.COM1,968,180$7.89M0.1%00.0%UnchangedHistory
RAPTRAPT Therapeutics, Inc.COM361,300$7.95M0.1%+144,300+66.5%AddedHistory
LENZLENZ Therapeutics, Inc.COM1,565,812$7.99M0.1%00.0%UnchangedHistory
IRONDisc Medicine, Inc.COM5,826,224$8.10M0.1%00.0%UnchangedHistory
ELVNEnliven Therapeutics, Inc.COM4,386,568$8.25M0.1%00.0%UnchangedHistory
Cybin Ord23256X100COM10,524,300$8.60M0.1%00.0%Unchanged–
DMRADamora Therapeutics, Inc.COM4,090,937$9.00M0.1%00.0%UnchangedHistory
JBIOJade Biosciences, Inc.COM509,949$9.35M0.2%−25,765−4.8%ReducedHistory
State Street SPDR S&P Biotech ETF78464A870ETF111,800$10.0M0.2%−897,900−88.9%Reduced–
Bellus Health Inc New07987C204COM NEW1,454,800$10.1M0.2%00.0%Unchanged–
ALXOAlx Oncology Holdings IncCOM621,700$10.5M0.2%+414,100+199.5%AddedHistory
LUNGPulmonx CorpCOM435,000$10.8M0.2%00.0%UnchangedHistory
ORICOric Pharmaceuticals, Inc.COM2,087,568$11.1M0.2%−250,006−10.7%ReducedHistory
TERNTerns Pharmaceuticals, Inc.COM3,791,204$11.3M0.2%00.0%UnchangedHistory
SGFYSignify Health, Inc.CL A COM620,700$11.3M0.2%+620,700NewHistory
CRVSCorvus Pharmaceuticals, Inc.COM6,943,654$11.4M0.2%00.0%UnchangedHistory
BridgeBio Pharma, Inc.10806XAB8NOTE 2.500% 3/1–$12.0M0.2%–New–
CMMBChemomab Therapeutics Ltd.SPONSORED ADS2,578,174$12.4M0.2%00.0%UnchangedHistory
Danaher Corp2358514095% CONV PFD B–$12.7M0.2%–––
LKFTLakefront Biotherapeutics NVSPON ADR208,225$12.9M0.2%−509,032−71.0%ReducedHistory
NXTCNextCure, Inc.COM2,711,013$13.2M0.2%00.0%UnchangedHistory
BNRBurning Rock Biotech LtdSPONSORED ADS1,452,402$13.5M0.2%00.0%UnchangedHistory
ETNB89bio, Inc.COM3,658,869$13.8M0.2%−70,573−1.9%ReducedHistory
AMGNAmgen IncStock57,100$13.8M0.2%00.0%UnchangedHistory
CLDXCelldex Therapeutics, Inc.COM NEW406,100$13.8M0.2%00.0%UnchangedHistory
ERASErasca, Inc.COM1,667,693$14.3M0.2%00.0%UnchangedHistory
BridgeBio Pharma, Inc.10806XAD4NOTE 2.250% 2/0–$14.4M0.2%–New–
SYBXSynlogic, Inc.COM6,029,995$14.5M0.2%00.0%UnchangedHistory
OMICSingular Genomics Systems, Inc.COM2,300,792$14.5M0.2%+196,433+9.3%AddedHistory
DBTXDecibel Therapeutics, Inc.COM4,945,192$15.0M0.2%00.0%UnchangedHistory
HARPHarpoon Therapeutics, Inc.COM3,039,508$15.1M0.2%+136,000+4.7%AddedHistory
ILMNIllumina, Inc.COM45,100$15.8M0.3%00.0%UnchangedHistory
VTGNVistagen Therapeutics, Inc.COM NEW12,909,283$16.0M0.3%00.0%UnchangedHistory
RAREUltragenyx Pharmaceutical Inc.COM227,600$16.5M0.3%+227,600NewHistory
MISTMilestone Pharmaceuticals Inc.COM2,583,821$16.6M0.3%00.0%UnchangedHistory
QUREuniQure N.V.SHS919,249$16.6M0.3%+333,675+57.0%AddedHistory
GILDGilead Sciences, Inc.Stock287,600$17.1M0.3%00.0%UnchangedHistory
RXSTRxSight, Inc.COM1,383,500$17.1M0.3%00.0%UnchangedHistory
VTYXVentyx Biosciences, Inc.COM1,289,280$17.5M0.3%00.0%UnchangedHistory
IMAImageneBio, Inc.COM2,933,941$17.9M0.3%00.0%UnchangedHistory
Gracell Biotechnologies Inc38406L103SPONSORED ADS7,884,870$18.4M0.3%00.0%Unchanged–
MRSNMersana Therapeutics, Inc.COM4,788,900$19.1M0.3%+1,900,053+65.8%AddedHistory
MREOMereo BioPharma Group plcSPON ADS10,154,810$19.3M0.3%––History
JNCEJounce Therapeutics, Inc.COM2,859,900$19.4M0.3%00.0%UnchangedHistory
XENEXenon Pharmaceuticals Inc.COM686,000$21.0M0.3%+55,000+8.7%AddedHistory
PASGPassage BIO, Inc.COM7,331,999$22.7M0.4%+369,100+5.3%AddedHistory
IVVDInvivyd, Inc.COM5,056,000$23.1M0.4%+72,500+1.5%AddedHistory
KDNYChinook Therapeutics, Inc.COM1,418,300$23.2M0.4%00.0%UnchangedHistory
BIIBBiogen Inc.COM117,900$24.8M0.4%−112,300−48.8%ReducedHistory
FUSNFusion Pharmaceuticals Inc.COM3,224,770$25.1M0.4%00.0%UnchangedHistory
Vectivbio Hldg AGH9060V101ORD SHS5,330,704$25.1M0.4%+106,900+2.0%Added–
GHRSGH Research PLCORDINARY SHARES1,428,732$26.1M0.4%00.0%UnchangedHistory
ACRSAclaris Therapeutics, Inc.COM1,579,900$27.2M0.4%+594,000+60.2%AddedHistory
SCPHscPharmaceuticals Inc.COM4,797,148$27.2M0.4%00.0%UnchangedHistory
VRNAVerona Pharma plcSPONSORED ADS5,694,841$28.4M0.5%00.0%UnchangedHistory
CMPXCompass Therapeutics, Inc.COM21,642,975$29.7M0.5%00.0%UnchangedHistory
SPRYARS Pharmaceuticals, Inc.COM8,740,887$30.7M0.5%00.0%UnchangedHistory
TBPHTheravance Biopharma, Inc.COM3,254,713$31.1M0.5%−2,719,822−45.5%ReducedHistory
NPCENeuroPace IncCOM4,012,281$32.9M0.5%00.0%UnchangedHistory
TELATELA Bio, Inc.COM3,027,542$35.2M0.6%00.0%UnchangedHistory
PCVXVaxcyte, Inc.COM1,513,659$36.6M0.6%+416,959+38.0%AddedHistory
ALPNAlpine Immune Sciences, Inc.COM4,081,592$36.6M0.6%00.0%UnchangedHistory
SNDXSyndax Pharmaceuticals IncCOM2,158,300$37.5M0.6%+177,000+8.9%AddedHistory
NSTGNS Wind Down Co., Inc.COM1,157,387$40.2M0.7%+350,287+43.4%AddedHistory
JANXJanux Therapeutics, Inc.COM2,836,386$40.7M0.7%00.0%UnchangedHistory
ABCLAbCellera Biologics Inc.COM4,180,768$40.8M0.7%00.0%UnchangedHistory
EVHEvolent Health, Inc.CL A1,400,000$45.2M0.7%+462,000+49.3%AddedHistory
KNTEKinnate Biopharma Inc.COM4,043,629$45.5M0.7%+195,700+5.1%AddedHistory

Options (2)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of OrbiMed Advisors LLC in Q1 2022
SecurityClassPutsCalls
NTRANatera, Inc.COM–$6.10M
GBTGlobal Blood Therapeutics, Inc.COM–$1.73M

Sold out since Q4 2021 (28)

Positions held at the end of Q4 2021 that are gone from this filing.

Positions of OrbiMed Advisors LLC sold out since Q4 2021
SecurityClassShares in Q4 2021Value in Q4 2021% of portfolio in Q4 2021History
MRKMerck & Co., Inc.Stock1,779,300$136.4M1.8%History
HCAHCA Healthcare, Inc.COM389,500$100.1M1.3%History
ZBHZimmer Biomet Holdings, Inc.Stock564,300$71.7M0.9%History
OSHOak Street Health, Inc.COM1,290,300$42.8M0.6%History
SEMSelect Medical Holdings CorpCOM1,233,600$36.3M0.5%History
CTKBCytek Biosciences, Inc.COM1,923,139$31.4M0.4%History
IMGNImmunoGen, Inc.COM3,868,786$28.7M0.4%History
APLTApplied Therapeutics, Inc.COM2,313,681$20.7M0.3%History
CRISCuris IncCOM NEW3,634,800$17.3M0.2%History
LABStandard Biotools Inc.COM3,819,348$15.0M0.2%History
RXDXPrometheus Biosciences, Inc.COM250,000$9.88M0.1%History
CVRXCVRx, Inc.COM723,055$8.84M0.1%History
GOSSGossamer Bio, Inc.COM683,000$7.72M0.1%History
NAUTNautilus Biotechnology, Inc.COM1,452,774$7.53M0.1%History
NTLAIntellia Therapeutics, Inc.COM53,200$6.29M0.1%History
SYRSSyros Pharmaceuticals, Inc.COM1,837,500$5.99M0.1%History
NRIXNurix Therapeutics, Inc.COM184,468$5.34M0.1%History
OBIOOrchestra BioMed Holdings, Inc.ORD SHS500,000$5.04M0.1%History
IPSCCentury Therapeutics, Inc.COM307,047$4.87M0.1%History
IFRXInflaRx N.V.COM875,297$4.17M0.1%History
INZYInozyme Pharma, Inc.COM526,600$3.59M<0.1%History
WHWKWhitehawk Therapeutics, Inc.COM127,600$3.08M<0.1%History
SURFSurface Oncology, Inc.COM467,945$2.24M<0.1%History
DRUGBright Minds Biosciences Inc.COM660,600$2.13M<0.1%History
ADAGAdagene Inc.ADS263,176$2.12M<0.1%History
GYREGyre Therapeutics, Inc.COM NEW1,729,402$1.58M<0.1%History
AUGXAugmedix, Inc.COM88,363$278.0K<0.1%History
SVASinovac Biotech LtdSHS2,839,500––History