| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Aug 17, 2026 | Joshi Manher | Chief Medical Officer | A | 25,000 | $0.0000 | $0.00 |
| Aug 17, 2026 | Joshi Manher | Chief Medical Officer | A | 50,000 | $0.0000 | $0.00 |
| Aug 13, 2026 | Garfield Alastair | Chief Scientific Officer | S | 800 | $119.1688 | $95.33K |
| Aug 13, 2026 | Garfield Alastair | Chief Scientific Officer | S | 3,400 | $118.2843 | $402.17K |
| Aug 13, 2026 | Garfield Alastair | Chief Scientific Officer | S | 1,556 | $117.0759 | $182.17K |
| Aug 13, 2026 | Garfield Alastair | Chief Scientific Officer | S | 2,007 | $116.1093 | $233.03K |
| Aug 13, 2026 | Shulman Joseph | Chief Technical Officer | M | 2,024 | $0.0000 | $0.00 |
| Aug 13, 2026 | Shulman Joseph | Chief Technical Officer | S | 5,079 | $119.7500 | $608.21K |
| Aug 13, 2026 | Shulman Joseph | Chief Technical Officer | M | 2,024 | $6.8000 | $13.76K |
| Aug 13, 2026 | Lee Jennifer Kayden | EVP, Head of North America | M | 21,601 | $0.0000 | $0.00 |
| Aug 13, 2026 | Lee Jennifer Kayden | EVP, Head of North America | M | 35,000 | $0.0000 | $0.00 |
| Aug 13, 2026 | Lee Jennifer Kayden | EVP, Head of North America | S | 75,834 | $117.3818 | $8.90M |
| Aug 13, 2026 | Lee Jennifer Kayden | EVP, Head of North America | M | 21,601 | $6.8000 | $146.89K |
| Aug 13, 2026 | Lee Jennifer Kayden | EVP, Head of North America | M | 35,000 | $24.2900 | $850.15K |
| Aug 12, 2026 | Mazabraud Yann | EVP, Head of International | M | 46,625 | $0.0000 | $0.00 |
| Aug 12, 2026 | Mazabraud Yann | EVP, Head of International | S | 17,319 | $117.4686 | $2.03M |
| Aug 12, 2026 | Mazabraud Yann | EVP, Head of International | S | 18,208 | $116.4941 | $2.12M |
| Aug 12, 2026 | Mazabraud Yann | EVP, Head of International | S | 14,568 | $115.4270 | $1.68M |
| Aug 12, 2026 | Mazabraud Yann | EVP, Head of International | S | 3,605 | $114.6955 | $413.48K |
| Aug 12, 2026 | Mazabraud Yann | EVP, Head of International | S | 1,000 | $112.8560 | $112.86K |
| Aug 12, 2026 | Mazabraud Yann | EVP, Head of International | S | 2,300 | $111.7992 | $257.14K |
| Aug 12, 2026 | Mazabraud Yann | EVP, Head of International | M | 46,625 | $6.8000 | $317.05K |
| Jul 1, 2026 | Garfield Alastair | Chief Scientific Officer | M | 4,445 | $0.0000 | $0.00 |
| Jul 1, 2026 | Garfield Alastair | Chief Scientific Officer | F | 2,150 | $110.4100 | $237.38K |
| Jul 1, 2026 | Garfield Alastair | Chief Scientific Officer | M | 4,445 | – | – |
| Jun 24, 2026 | GOOD JENNIFER L | Director | A | 2,324 | $0.0000 | $0.00 |
| Jun 24, 2026 | GOOD JENNIFER L | Director | A | 3,691 | $0.0000 | $0.00 |
| Jun 24, 2026 | Arbuckle Stuart A | Director | A | 2,324 | $0.0000 | $0.00 |
| Jun 24, 2026 | Arbuckle Stuart A | Director | A | 3,691 | $0.0000 | $0.00 |
| Jun 24, 2026 | MCGIRR DAVID W J | Director | A | 2,324 | $0.0000 | $0.00 |
| Jun 24, 2026 | MCGIRR DAVID W J | Director | A | 3,691 | $0.0000 | $0.00 |
| Jun 24, 2026 | JEAN CHRISTOPHE | Director | A | 2,324 | $0.0000 | $0.00 |
| Jun 24, 2026 | JEAN CHRISTOPHE | Director | A | 3,691 | $0.0000 | $0.00 |
| Jun 24, 2026 | TETRAULT LYNN A. | Director | A | 2,324 | $0.0000 | $0.00 |
| Jun 24, 2026 | TETRAULT LYNN A. | Director | A | 3,691 | $0.0000 | $0.00 |
| Jun 23, 2026 | GOOD JENNIFER L | Director | M | 4,712 | $0.0000 | $0.00 |
| Jun 23, 2026 | GOOD JENNIFER L | Director | M | 4,712 | – | – |
| Jun 23, 2026 | Arbuckle Stuart A | Director | M | 4,712 | $0.0000 | $0.00 |
| Jun 23, 2026 | Arbuckle Stuart A | Director | M | 4,712 | – | – |
| Jun 23, 2026 | MCGIRR DAVID W J | Director | M | 4,712 | $0.0000 | $0.00 |
| Jun 23, 2026 | MCGIRR DAVID W J | Director | M | 4,712 | – | – |
| Jun 23, 2026 | JEAN CHRISTOPHE | Director | M | 4,712 | $0.0000 | $0.00 |
| Jun 23, 2026 | JEAN CHRISTOPHE | Director | M | 4,712 | – | – |
| Jun 23, 2026 | TETRAULT LYNN A. | Director | M | 4,712 | $0.0000 | $0.00 |
| Jun 23, 2026 | TETRAULT LYNN A. | Director | M | 4,712 | – | – |
| Jun 22, 2026 | TETRAULT LYNN A. | Director | M | 37,000 | $0.0000 | $0.00 |
| Jun 22, 2026 | TETRAULT LYNN A. | Director | S | 37,000 | $100.3215 | $3.71M |
| Jun 22, 2026 | TETRAULT LYNN A. | Director | M | 37,000 | $28.2700 | $1.05M |
| May 18, 2026 | Smith Hunter C | Chief Financial Officer | M | 3,000 | $0.0000 | $0.00 |
| May 18, 2026 | Smith Hunter C | Chief Financial Officer | M | 3,000 | $17.8700 | $53.61K |