| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Aug 17, 2026 | Goncalves Joana | Chief Medical Officer | M | 3,500 | $0.0000 | $0.00 |
| Aug 17, 2026 | Goncalves Joana | Chief Medical Officer | M | 3,500 | $0.0000 | $0.00 |
| Aug 17, 2026 | Goncalves Joana | Chief Medical Officer | S | 2,480 | $112.5622 | $279.15K |
| Aug 17, 2026 | Goncalves Joana | Chief Medical Officer | S | 3,320 | $112.0138 | $371.88K |
| Aug 17, 2026 | Goncalves Joana | Chief Medical Officer | S | 300 | $110.5167 | $33.16K |
| Aug 17, 2026 | Goncalves Joana | Chief Medical Officer | S | 900 | $109.6522 | $98.69K |
| Aug 17, 2026 | Goncalves Joana | Chief Medical Officer | M | 3,500 | $7.8000 | $27.30K |
| Aug 17, 2026 | Goncalves Joana | Chief Medical Officer | M | 3,500 | $6.8400 | $23.94K |
| Aug 14, 2026 | Quinlan Paul T | General Counsel | M | 42,000 | $0.0000 | $0.00 |
| Aug 14, 2026 | Quinlan Paul T | General Counsel | M | 10,000 | $0.0000 | $0.00 |
| Aug 14, 2026 | Quinlan Paul T | General Counsel | S | 3,847 | $111.1378 | $427.55K |
| Aug 14, 2026 | Quinlan Paul T | General Counsel | S | 9,193 | $110.0039 | $1.01M |
| Aug 14, 2026 | Quinlan Paul T | General Counsel | S | 10,200 | $109.1131 | $1.11M |
| Aug 14, 2026 | Quinlan Paul T | General Counsel | S | 14,696 | $107.9735 | $1.59M |
| Aug 14, 2026 | Quinlan Paul T | General Counsel | S | 10,434 | $107.1402 | $1.12M |
| Aug 14, 2026 | Quinlan Paul T | General Counsel | S | 3,630 | $106.0504 | $384.96K |
| Aug 14, 2026 | Quinlan Paul T | General Counsel | M | 42,000 | $12.5000 | $525.00K |
| Aug 14, 2026 | Quinlan Paul T | General Counsel | M | 10,000 | $7.8000 | $78.00K |
| Aug 13, 2026 | Agarwal Arjun | Senior Vice President, Finance | M | 1,458 | $0.0000 | $0.00 |
| Aug 13, 2026 | Agarwal Arjun | Senior Vice President, Finance | M | 8,542 | $0.0000 | $0.00 |
| Aug 13, 2026 | Agarwal Arjun | Senior Vice President, Finance | S | 2,358 | $108.4628 | $255.75K |
| Aug 13, 2026 | Agarwal Arjun | Senior Vice President, Finance | S | 2,142 | $107.7138 | $230.72K |
| Aug 13, 2026 | Agarwal Arjun | Senior Vice President, Finance | S | 1,268 | $106.6255 | $135.20K |
| Aug 13, 2026 | Agarwal Arjun | Senior Vice President, Finance | S | 2,132 | $105.5716 | $225.08K |
| Aug 13, 2026 | Agarwal Arjun | Senior Vice President, Finance | S | 2,100 | $104.6734 | $219.81K |
| Aug 13, 2026 | Agarwal Arjun | Senior Vice President, Finance | M | 1,458 | $34.3900 | $50.14K |
| Aug 13, 2026 | Agarwal Arjun | Senior Vice President, Finance | M | 8,542 | $12.5000 | $106.78K |
| Jul 15, 2026 | Goncalves Joana | Chief Medical Officer | M | 3,500 | $0.0000 | $0.00 |
| Jul 15, 2026 | Goncalves Joana | Chief Medical Officer | M | 3,500 | $0.0000 | $0.00 |
| Jul 15, 2026 | Goncalves Joana | Chief Medical Officer | S | 300 | $87.2533 | $26.18K |
| Jul 15, 2026 | Goncalves Joana | Chief Medical Officer | S | 3,803 | $86.6764 | $329.63K |
| Jul 15, 2026 | Goncalves Joana | Chief Medical Officer | S | 2,497 | $85.8572 | $214.38K |
| Jul 15, 2026 | Goncalves Joana | Chief Medical Officer | S | 400 | $84.3650 | $33.75K |
| Jul 15, 2026 | Goncalves Joana | Chief Medical Officer | M | 3,500 | $7.8000 | $27.30K |
| Jul 15, 2026 | Goncalves Joana | Chief Medical Officer | M | 3,500 | $6.8400 | $23.94K |
| Jul 13, 2026 | Agarwal Arjun | Senior Vice President, Finance | M | 1,458 | $0.0000 | $0.00 |
| Jul 13, 2026 | Agarwal Arjun | Senior Vice President, Finance | M | 8,541 | $0.0000 | $0.00 |
| Jul 13, 2026 | Agarwal Arjun | Senior Vice President, Finance | S | 300 | $85.6333 | $25.69K |
| Jul 13, 2026 | Agarwal Arjun | Senior Vice President, Finance | S | 5,656 | $84.9012 | $480.20K |
| Jul 13, 2026 | Agarwal Arjun | Senior Vice President, Finance | S | 3,743 | $84.2557 | $315.37K |
| Jul 13, 2026 | Agarwal Arjun | Senior Vice President, Finance | S | 300 | $83.0665 | $24.92K |
| Jul 13, 2026 | Agarwal Arjun | Senior Vice President, Finance | M | 1,458 | $34.3900 | $50.14K |
| Jul 13, 2026 | Agarwal Arjun | Senior Vice President, Finance | M | 8,541 | $12.5000 | $106.76K |
| Jul 1, 2026 | Sandler Laura Lee | Chief Operating Officer | M | 5,000 | $0.0000 | $0.00 |
| Jul 1, 2026 | Sandler Laura Lee | Chief Operating Officer | S | 500 | $95.4720 | $47.74K |
| Jul 1, 2026 | Sandler Laura Lee | Chief Operating Officer | S | 2,263 | $94.7458 | $214.41K |
| Jul 1, 2026 | Sandler Laura Lee | Chief Operating Officer | S | 2,237 | $93.8457 | $209.93K |
| Jul 1, 2026 | Sandler Laura Lee | Chief Operating Officer | M | 5,000 | $7.8000 | $39.00K |
| Jul 1, 2026 | Fairmount Funds Management LLC | Director, 10% Owner | C | 3,553,410 | $0.0000 | $0.00 |
| Jul 1, 2026 | Fairmount Funds Management LLC | Director, 10% Owner | S | 3,553,410 | $84.4300 | $300.01M |