| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Aug 17, 2026 | Kelley Shannon T | General Counsel | S | 664 | $514.9700 | $341.94K |
| Aug 15, 2026 | REED JOHN C | Director | A | 1,078 | $0.0000 | $0.00 |
| Aug 15, 2026 | REED JOHN C | Director | A | 647 | $0.0000 | $0.00 |
| Jul 20, 2026 | Sibold William John | President and CEO | S | 280 | $555.0500 | $155.41K |
| Jul 20, 2026 | Sibold William John | President and CEO | S | 1 | $550.7200 | $550.00 |
| Jul 20, 2026 | Sibold William John | President and CEO | S | 153 | $550.0138 | $84.15K |
| Jul 20, 2026 | Sibold William John | President and CEO | S | 47 | $548.8719 | $25.80K |
| Jul 20, 2026 | Sibold William John | President and CEO | S | 680 | $547.6980 | $372.43K |
| Jul 20, 2026 | Sibold William John | President and CEO | S | 269 | $547.0788 | $147.16K |
| Jul 20, 2026 | Sibold William John | President and CEO | S | 275 | $545.7092 | $150.07K |
| Jul 20, 2026 | Sibold William John | President and CEO | S | 545 | $544.7140 | $296.87K |
| Jul 20, 2026 | Sibold William John | President and CEO | S | 110 | $543.7929 | $59.82K |
| Jul 20, 2026 | Sibold William John | President and CEO | S | 140 | $542.7459 | $75.98K |
| Jul 17, 2026 | Sibold William John | President and CEO | M | 50,000 | $0.0000 | $0.00 |
| Jul 17, 2026 | Sibold William John | President and CEO | M | 50,000 | – | – |
| Jun 17, 2026 | BAKER BROS. ADVISORS LP | Director | A | 1,532 | $0.0000 | $0.00 |
| Jun 17, 2026 | BAKER BROS. ADVISORS LP | Director | A | 1,532 | $0.0000 | $0.00 |
| Jun 17, 2026 | BAKER BROS. ADVISORS LP | Director | A | 908 | $0.0000 | $0.00 |
| Jun 17, 2026 | BAKER BROS. ADVISORS LP | Director | A | 908 | $0.0000 | $0.00 |
| Jun 17, 2026 | Brennan Daniel J. | Director | A | 681 | $0.0000 | $0.00 |
| Jun 17, 2026 | Brennan Daniel J. | Director | A | 404 | $0.0000 | $0.00 |
| Jun 17, 2026 | Daly James M | Director | A | 766 | $0.0000 | $0.00 |
| Jun 17, 2026 | Daly James M | Director | A | 454 | $0.0000 | $0.00 |
| Jun 17, 2026 | FOUSE JACQUALYN A | Director | A | 766 | $0.0000 | $0.00 |
| Jun 17, 2026 | FOUSE JACQUALYN A | Director | A | 454 | $0.0000 | $0.00 |
| Jun 17, 2026 | Levy Richard S | Director | A | 766 | $0.0000 | $0.00 |
| Jun 17, 2026 | Levy Richard S | Director | A | 454 | $0.0000 | $0.00 |
| Jun 17, 2026 | Taub Rebecca | Director | A | 766 | $0.0000 | $0.00 |
| Jun 17, 2026 | Taub Rebecca | Director | A | 454 | $0.0000 | $0.00 |
| Jun 1, 2026 | Soergel David | Chief Medical Officer | S | 1,042 | $495.7400 | $516.56K |
| May 22, 2026 | Levy Richard S | Director | S | 80 | $519.9800 | $41.60K |
| May 22, 2026 | Levy Richard S | Director | S | 782 | $518.7580 | $405.67K |
| May 22, 2026 | Levy Richard S | Director | S | 1,497 | $517.5921 | $774.84K |
| May 22, 2026 | Levy Richard S | Director | S | 723 | $516.8658 | $373.69K |
| May 22, 2026 | Levy Richard S | Director | S | 657 | $515.9219 | $338.96K |
| May 22, 2026 | Levy Richard S | Director | S | 343 | $514.6691 | $176.53K |
| May 22, 2026 | Levy Richard S | Director | S | 40 | $512.9700 | $20.52K |
| May 22, 2026 | Levy Richard S | Director | S | 439 | $512.5022 | $224.99K |
| May 22, 2026 | Levy Richard S | Director | S | 610 | $511.3967 | $311.95K |
| May 22, 2026 | Levy Richard S | Director | S | 151 | $510.3579 | $77.06K |
| May 22, 2026 | Levy Richard S | Director | S | 320 | $508.2420 | $162.64K |
| May 22, 2026 | Levy Richard S | Director | S | 40 | $506.6750 | $20.27K |
| May 18, 2026 | Soergel David | Chief Medical Officer | S | 844 | $515.9000 | $435.42K |
| Mar 6, 2026 | Taub Rebecca | Director | S | 491 | $431.9400 | $212.08K |
| Mar 6, 2026 | Huntsman Carole | Chief Commercial Officer | S | 419 | $431.9400 | $180.98K |
| Mar 6, 2026 | Kelley Shannon T | General Counsel | S | 360 | $431.9400 | $155.50K |
| Mar 6, 2026 | Sibold William John | President and CEO | S | 1,663 | $431.9400 | $718.32K |
| Mar 6, 2026 | Dier Mardi | EVP and CFO | S | 40 | $437.6500 | $17.51K |
| Mar 6, 2026 | Dier Mardi | EVP and CFO | S | 80 | $436.6900 | $34.94K |
| Mar 6, 2026 | Dier Mardi | EVP and CFO | S | 80 | $435.3150 | $34.83K |