Aug 6, 2026 Schneyer Mark C. EVP, CHIEF FINANCIAL OFFICER M 14,292 $0.0000 $0.00 Aug 6, 2026 Schneyer Mark C. EVP, CHIEF FINANCIAL OFFICER 9,292 $29.3375 $272.60K Aug 6, 2026 Schneyer Mark C. EVP, CHIEF FINANCIAL OFFICER 5,000 $29.0000 $145.00K Aug 6, 2026 Schneyer Mark C. EVP, CHIEF FINANCIAL OFFICER M 14,292 $17.8400 $254.97K Aug 5, 2026 Schneyer Mark C. EVP, CHIEF FINANCIAL OFFICER M 5,849 $0.0000 $0.00 Aug 5, 2026 Schneyer Mark C. EVP, CHIEF FINANCIAL OFFICER 5,849 $29.0029 $169.64K Aug 5, 2026 Schneyer Mark C. EVP, CHIEF FINANCIAL OFFICER M 5,849 $17.8400 $104.35K Jul 30, 2026 Thompson Elizabeth H.Z. EVP, Head of Research & Dev 50 $26.1700 $1.31K Jul 30, 2026 Thompson Elizabeth H.Z. EVP, Head of Research & Dev 16,508 $26.1300 $431.35K Jul 29, 2026 Thompson Elizabeth H.Z. EVP, Head of Research & Dev M 32,272 $0.0000 $0.00 Jul 29, 2026 Thompson Elizabeth H.Z. EVP, Head of Research & Dev M 32,272 – – Jun 26, 2026 Kihara James PRINCIPAL ACCOUNTING OFFICER 11,421 $26.0846 $297.91K May 29, 2026 BAKER BROS. ADVISORS LP Director, 10% Owner 32,008 $0.0000 $0.00 May 29, 2026 BAKER BROS. ADVISORS LP Director, 10% Owner 32,008 $0.0000 $0.00 May 29, 2026 BAKER BROS. ADVISORS LP Director, 10% Owner 18,622 $0.0000 $0.00 May 29, 2026 BAKER BROS. ADVISORS LP Director, 10% Owner 18,622 $0.0000 $0.00 May 29, 2026 Daly James M Director 9,311 $0.0000 $0.00 May 29, 2026 Daly James M Director 16,004 $0.0000 $0.00 May 29, 2026 Daly James M Director M 8,107 $0.0000 $0.00 May 29, 2026 Daly James M Director M 8,107 – – May 29, 2026 GAROFALO ELIZABETH A. Director 9,311 $0.0000 $0.00 May 29, 2026 GAROFALO ELIZABETH A. Director 16,004 $0.0000 $0.00 May 29, 2026 GAROFALO ELIZABETH A. Director M 8,107 $0.0000 $0.00 May 29, 2026 Brege Laura Director 9,311 $0.0000 $0.00 May 29, 2026 Brege Laura Director 16,004 $0.0000 $0.00 May 29, 2026 Brege Laura Director M 8,107 $0.0000 $0.00 May 29, 2026 GAROFALO ELIZABETH A. Director M 8,107 – – May 29, 2026 Brege Laura Director M 8,107 – – May 29, 2026 Poole Jonathan Director 9,311 $0.0000 $0.00 May 29, 2026 Poole Jonathan Director 16,004 $0.0000 $0.00 May 29, 2026 Poole Jonathan Director M 2,010 $0.0000 $0.00 May 29, 2026 Poole Jonathan Director M 2,010 – – May 29, 2026 Ndu Adora Director 9,311 $0.0000 $0.00 May 29, 2026 Ndu Adora Director 16,004 $0.0000 $0.00 May 29, 2026 Ndu Adora Director M 8,107 $0.0000 $0.00 May 29, 2026 Ndu Adora Director M 8,107 – – May 29, 2026 HARRIGAN EDMUND Director 9,311 $0.0000 $0.00 May 29, 2026 HARRIGAN EDMUND Director 16,004 $0.0000 $0.00 May 29, 2026 HARRIGAN EDMUND Director M 8,107 $0.0000 $0.00 May 29, 2026 HARRIGAN EDMUND Director M 8,107 – – May 26, 2026 Kihara James PRINCIPAL ACCOUNTING OFFICER 5,401 $21.1800 $114.39K May 4, 2026 Schneyer Mark C. EVP, CHIEF FINANCIAL OFFICER 3,506 $21.7900 $76.39K May 4, 2026 Kihara James PRINCIPAL ACCOUNTING OFFICER 1,332 $21.7900 $29.02K May 1, 2026 Schneyer Mark C. EVP, CHIEF FINANCIAL OFFICER M 6,815 $0.0000 $0.00 May 1, 2026 Schneyer Mark C. EVP, CHIEF FINANCIAL OFFICER M 6,815 – – May 1, 2026 Kihara James PRINCIPAL ACCOUNTING OFFICER M 2,596 $0.0000 $0.00 May 1, 2026 Kihara James PRINCIPAL ACCOUNTING OFFICER M 2,596 – – Apr 7, 2026 Kihara James PRINCIPAL ACCOUNTING OFFICER 1,030 $22.2000 $22.87K Apr 7, 2026 Schneyer Mark C. EVP, CHIEF FINANCIAL OFFICER 2,709 $22.2000 $60.14K Apr 5, 2026 Kihara James PRINCIPAL ACCOUNTING OFFICER M 2,010 $0.0000 $0.00