| Erste Asset Management GmbH | 18,700 | $167.4 萬 | 0.04% | – | – |
| Manufacturers Life Insurance Company, The | 20,935 | $198.0 萬 | 0.00% | – | – |
| American International Group, Inc. | 21,761 | $205.8 萬 | 0.01% | – | – |
| Man Group plc | 21,860 | $206.8 萬 | 0.01% | – | – |
| Russell Investments Group, Ltd. | 23,661 | $223.7 萬 | 0.00% | – | – |
| Legal & General Group Plc | 24,145 | $228.4 萬 | 0.00% | – | – |
| Handelsinvest Investeringsforvaltning | 25,000 | $236.5 萬 | 0.29% | – | – |
| SG Americas Securities, LLC | 25,676 | $242.9 萬 | 0.01% | – | – |
| State of New Jersey Common Pension Fund D | 26,430 | $250.0 萬 | 0.01% | – | – |
| Duality Advisers, LP | 27,253 | $257.8 萬 | 0.22% | – | – |
| Voloridge Investment Management, LLC | 27,615 | $261.2 萬 | 0.02% | – | – |
| Rafferty Asset Management, LLC | 29,058 | $274.9 萬 | 0.02% | – | – |
| JPMorgan Chase & Co | 30,723 | $290.6 萬 | 0.00% | – | – |
| Cubist Systematic Strategies, LLC | 37,117 | $351.1 萬 | 0.04% | – | – |
| Fiera Capital Corp | 37,570 | $355.4 萬 | 0.01% | – | – |
| Neuberger Berman Group LLC | 39,896 | $377.3 萬 | 0.00% | – | – |
| UBS Group AG | 41,792 | $395.3 萬 | 0.00% | – | – |
| Citigroup Inc | 41,919 | $396.6 萬 | 0.00% | – | – |
| UBS Asset Management Americas Inc | 42,438 | $401.4 萬 | 0.00% | – | – |
| Ergoteles LLC | 42,465 | $401.7 萬 | 0.12% | – | – |
| Barclays PLC | 42,888 | $405.6 萬 | 0.00% | – | – |
| Rhumbline Advisers | 43,455 | $411.0 萬 | 0.01% | – | – |
| Prudential Financial Inc | 45,096 | $426.6 萬 | 0.01% | – | – |
| Woodline Partners LP | 46,200 | $437.0 萬 | 0.10% | – | – |
| New York State Common Retirement Fund | 47,276 | $447.2 萬 | 0.00% | – | – |
| Segall Bryant & Hamill, LLC | 48,939 | $462.8 萬 | 0.05% | – | – |
| Granahan Investment Management Inc | 49,413 | $467.4 萬 | 0.10% | – | – |
| Royal Bank of Canada | 51,293 | $485.2 萬 | 0.00% | – | – |
| TD Asset Management Inc | 52,160 | $493.4 萬 | 0.01% | – | – |
| WCM Investment Management, LLC | 52,231 | $494.1 萬 | 0.01% | – | – |
| State of Wisconsin Investment Board | 53,600 | $507.0 萬 | 0.01% | – | – |
| Putnam Investments LLC | 55,759 | $527.5 萬 | 0.01% | – | – |
| Osterweis Capital Management Inc | 55,790 | $527.7 萬 | 0.29% | – | – |
| Deutsche Bank AG | 55,972 | $529.4 萬 | 0.00% | – | – |
| California State Teachers Retirement System | 56,301 | $532.6 萬 | 0.01% | – | – |
| Allianz Asset Management GmbH | 56,841 | $537.7 萬 | 0.01% | – | – |
| First Light Asset Management, LLC | 58,879 | $556.9 萬 | 0.37% | – | – |
| Fred Alger Management, LLC | 63,706 | $602.6 萬 | 0.02% | – | – |
| Millennium Management LLC | 65,282 | $617.5 萬 | 0.01% | – | – |
| Bank of America Corp | 66,138 | $625.6 萬 | 0.00% | – | – |
| Burrage Capital Management LLC | 72,164 | $682.6 萬 | 5.53% | – | – |
| Casdin Capital, LLC | 75,000 | $709.4 萬 | 0.21% | – | – |
| Castleark Management LLC | 77,132 | $729.6 萬 | 0.26% | – | – |
| AXA S.A. | 81,506 | $771.0 萬 | 0.02% | – | – |
| International Biotechnology Trust PLC | 81,541 | $771.1 萬 | 2.04% | – | – |
| Deerfield Management Company, L.P. (Series C) | 83,846 | $793.1 萬 | 0.17% | – | – |
| California Public Employees Retirement System | 89,443 | $846.0 萬 | 0.01% | – | – |
| Swiss National Bank | 93,600 | $885.4 萬 | 0.01% | – | – |
| Dimensional Fund Advisors LP | 94,824 | $898.9 萬 | 0.00% | – | – |
| Peregrine Capital Management LLC | 97,015 | $917.7 萬 | 0.17% | – | – |
| Adage Capital Partners GP, L.L.C. | 100,000 | $945.9 萬 | 0.02% | – | – |
| Citadel Advisors LLC | 103,986 | $983.6 萬 | 0.01% | – | – |
| Two Sigma Advisers, LP | 117,000 | $1,107 萬 | 0.03% | – | – |
| Renaissance Technologies LLC | 118,300 | $1,119 萬 | 0.01% | – | – |
| Tekla Capital Management LLC | 119,324 | $1,129 萬 | 0.39% | – | – |
| Matthews International Capital Management LLC | 135,900 | $1,286 萬 | 0.54% | – | – |
| Logos Global Management LP | 140,000 | $1,324 萬 | 1.29% | – | – |
| Handelsbanken Fonder AB | 141,600 | $1,339 萬 | 0.08% | – | – |
| Bank of New York Mellon Corp | 156,958 | $1,485 萬 | 0.00% | – | – |
| Emerald Advisers, LLC | 180,508 | $1,707 萬 | 0.62% | – | – |
| Massachusetts Financial Services Co | 184,659 | $1,747 萬 | 0.01% | – | – |
| Emerald Mutual Fund Advisers Trust | 185,665 | $1,756 萬 | 0.58% | – | – |
| Two Sigma Investments, LP | 188,704 | $1,785 萬 | 0.05% | – | – |
| Nuveen Asset Management, LLC | 201,451 | $1,906 萬 | 0.01% | – | – |
| Driehaus Capital Management LLC | 205,124 | $1,940 萬 | 0.29% | – | – |
| Nicholas Investment Partners, LP | 218,847 | $2,070 萬 | 1.44% | – | – |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 222,931 | $2,109 萬 | 0.09% | – | – |
| Invesco Ltd. | 233,150 | $2,205 萬 | 0.01% | – | – |
| D. E. Shaw & Co., Inc. | 255,929 | $2,421 萬 | 0.03% | – | – |
| Sectoral Asset Management Inc | 257,879 | $2,439 萬 | 1.85% | – | – |
| MPM Oncology Impact Management LP | 269,186 | $2,546 萬 | 3.20% | – | – |
| Charles Schwab Investment Management Inc | 293,227 | $2,774 萬 | 0.01% | – | – |
| Artal Group S.A. | 312,700 | $2,958 萬 | 0.63% | – | – |
| Norges Bank | 332,330 | $3,144 萬 | 0.01% | – | – |
| American Century Companies Inc | 362,806 | $3,432 萬 | 0.03% | – | – |
| Eagle Asset Management Inc | 425,873 | $3,858 萬 | 0.17% | – | – |
| Goldman Sachs Group Inc | 410,782 | $3,886 萬 | 0.01% | – | – |
| Westfield Capital Management Co LP | 413,005 | $3,907 萬 | 0.24% | – | – |
| Northern Trust Corp | 420,889 | $3,981 萬 | 0.01% | – | – |
| Consonance Capital Management LP | 450,396 | $4,260 萬 | 4.54% | – | – |
| Victory Capital Management Inc | 464,833 | $4,397 萬 | 0.05% | – | – |
| Primecap Management Co | 466,240 | $4,410 萬 | 0.03% | – | – |
| Farallon Capital Management, L.L.C. | 500,000 | $4,730 萬 | 0.25% | – | – |
| Eventide Asset Management, LLC | 505,000 | $4,777 萬 | 0.71% | – | – |
| Candriam Luxembourg S.C.A. | 456,941 | $5,348 萬 | 0.45% | – | – |
| Alkeon Capital Management LLC | 629,069 | $5,950 萬 | 0.23% | – | – |
| Wells Fargo & Company | 639,137 | $6,046 萬 | 0.01% | – | – |
| Geode Capital Management, LLC | 677,940 | $6,413 萬 | 0.01% | – | – |
| Credit Suisse AG | 808,762 | $7,650 萬 | 0.06% | – | – |
| Pictet Asset Management Ltd | 816,204 | $7,721 萬 | 0.09% | – | – |
| Jennison Associates LLC | 859,811 | $8,133 萬 | 0.06% | – | – |
| Federated Hermes, Inc. | 973,186 | $9,205 萬 | 0.18% | – | – |
| Alliancebernstein L.P. | 1,055,886 | $9,988 萬 | 0.04% | – | – |
| Lord, Abbett & Co. LLC | 1,103,796 | $1.04 億 | 0.27% | – | – |
| State Street Corp | 1,149,563 | $1.09 億 | 0.01% | – | – |
| Wellington Management Group LLP | 2,101,844 | $1.99 億 | 0.04% | – | – |
| OrbiMed Advisors LLC | 2,361,327 | $2.23 億 | 2.11% | – | – |
| Price T Rowe Associates Inc | 2,521,043 | $2.38 億 | 0.02% | – | – |
| Cormorant Asset Management, LP | 2,750,000 | $2.60 億 | 7.49% | – | – |
| BlackRock Inc. | 3,177,645 | $3.01 億 | 0.01% | – | – |
