| Aug 6, 2026 | Schneyer Mark C. | EVP, CHIEF FINANCIAL OFFICER | M | 14,292 | $0.0000 | $0.00 |
| Aug 6, 2026 | Schneyer Mark C. | EVP, CHIEF FINANCIAL OFFICER | S | 9,292 | $29.3375 | $272.60K |
| Aug 6, 2026 | Schneyer Mark C. | EVP, CHIEF FINANCIAL OFFICER | S | 5,000 | $29.0000 | $145.00K |
| Aug 6, 2026 | Schneyer Mark C. | EVP, CHIEF FINANCIAL OFFICER | M | 14,292 | $17.8400 | $254.97K |
| Aug 5, 2026 | Schneyer Mark C. | EVP, CHIEF FINANCIAL OFFICER | M | 5,849 | $0.0000 | $0.00 |
| Aug 5, 2026 | Schneyer Mark C. | EVP, CHIEF FINANCIAL OFFICER | S | 5,849 | $29.0029 | $169.64K |
| Aug 5, 2026 | Schneyer Mark C. | EVP, CHIEF FINANCIAL OFFICER | M | 5,849 | $17.8400 | $104.35K |
| Jul 30, 2026 | Thompson Elizabeth H.Z. | EVP, Head of Research & Dev | S | 50 | $26.1700 | $1.31K |
| Jul 30, 2026 | Thompson Elizabeth H.Z. | EVP, Head of Research & Dev | S | 16,508 | $26.1300 | $431.35K |
| Jul 29, 2026 | Thompson Elizabeth H.Z. | EVP, Head of Research & Dev | M | 32,272 | $0.0000 | $0.00 |
| Jul 29, 2026 | Thompson Elizabeth H.Z. | EVP, Head of Research & Dev | M | 32,272 | – | – |
| Jun 26, 2026 | Kihara James | PRINCIPAL ACCOUNTING OFFICER | S | 11,421 | $26.0846 | $297.91K |
| May 29, 2026 | BAKER BROS. ADVISORS LP | Director, 10% Owner | A | 32,008 | $0.0000 | $0.00 |
| May 29, 2026 | BAKER BROS. ADVISORS LP | Director, 10% Owner | A | 32,008 | $0.0000 | $0.00 |
| May 29, 2026 | BAKER BROS. ADVISORS LP | Director, 10% Owner | A | 18,622 | $0.0000 | $0.00 |
| May 29, 2026 | BAKER BROS. ADVISORS LP | Director, 10% Owner | A | 18,622 | $0.0000 | $0.00 |
| May 29, 2026 | Daly James M | Director | A | 9,311 | $0.0000 | $0.00 |
| May 29, 2026 | Daly James M | Director | A | 16,004 | $0.0000 | $0.00 |
| May 29, 2026 | Daly James M | Director | M | 8,107 | $0.0000 | $0.00 |
| May 29, 2026 | Daly James M | Director | M | 8,107 | – | – |
| May 29, 2026 | GAROFALO ELIZABETH A. | Director | A | 9,311 | $0.0000 | $0.00 |
| May 29, 2026 | GAROFALO ELIZABETH A. | Director | A | 16,004 | $0.0000 | $0.00 |
| May 29, 2026 | GAROFALO ELIZABETH A. | Director | M | 8,107 | $0.0000 | $0.00 |
| May 29, 2026 | Brege Laura | Director | A | 9,311 | $0.0000 | $0.00 |
| May 29, 2026 | Brege Laura | Director | A | 16,004 | $0.0000 | $0.00 |
| May 29, 2026 | Brege Laura | Director | M | 8,107 | $0.0000 | $0.00 |
| May 29, 2026 | GAROFALO ELIZABETH A. | Director | M | 8,107 | – | – |
| May 29, 2026 | Brege Laura | Director | M | 8,107 | – | – |
| May 29, 2026 | Poole Jonathan | Director | A | 9,311 | $0.0000 | $0.00 |
| May 29, 2026 | Poole Jonathan | Director | A | 16,004 | $0.0000 | $0.00 |
| May 29, 2026 | Poole Jonathan | Director | M | 2,010 | $0.0000 | $0.00 |
| May 29, 2026 | Poole Jonathan | Director | M | 2,010 | – | – |
| May 29, 2026 | Ndu Adora | Director | A | 9,311 | $0.0000 | $0.00 |
| May 29, 2026 | Ndu Adora | Director | A | 16,004 | $0.0000 | $0.00 |
| May 29, 2026 | Ndu Adora | Director | M | 8,107 | $0.0000 | $0.00 |
| May 29, 2026 | Ndu Adora | Director | M | 8,107 | – | – |
| May 29, 2026 | HARRIGAN EDMUND | Director | A | 9,311 | $0.0000 | $0.00 |
| May 29, 2026 | HARRIGAN EDMUND | Director | A | 16,004 | $0.0000 | $0.00 |
| May 29, 2026 | HARRIGAN EDMUND | Director | M | 8,107 | $0.0000 | $0.00 |
| May 29, 2026 | HARRIGAN EDMUND | Director | M | 8,107 | – | – |
| May 26, 2026 | Kihara James | PRINCIPAL ACCOUNTING OFFICER | S | 5,401 | $21.1800 | $114.39K |
| May 4, 2026 | Schneyer Mark C. | EVP, CHIEF FINANCIAL OFFICER | S | 3,506 | $21.7900 | $76.39K |
| May 4, 2026 | Kihara James | PRINCIPAL ACCOUNTING OFFICER | S | 1,332 | $21.7900 | $29.02K |
| May 1, 2026 | Schneyer Mark C. | EVP, CHIEF FINANCIAL OFFICER | M | 6,815 | $0.0000 | $0.00 |
| May 1, 2026 | Schneyer Mark C. | EVP, CHIEF FINANCIAL OFFICER | M | 6,815 | – | – |
| May 1, 2026 | Kihara James | PRINCIPAL ACCOUNTING OFFICER | M | 2,596 | $0.0000 | $0.00 |
| May 1, 2026 | Kihara James | PRINCIPAL ACCOUNTING OFFICER | M | 2,596 | – | – |
| Apr 7, 2026 | Kihara James | PRINCIPAL ACCOUNTING OFFICER | S | 1,030 | $22.2000 | $22.87K |
| Apr 7, 2026 | Schneyer Mark C. | EVP, CHIEF FINANCIAL OFFICER | S | 2,709 | $22.2000 | $60.14K |
| Apr 5, 2026 | Kihara James | PRINCIPAL ACCOUNTING OFFICER | M | 2,010 | $0.0000 | $0.00 |