| Feb 4, 2025 (view filing) | Feb 3 | 1 day | Reed Elizabeth ESVP, GC & CORPORATE SECRETARY | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −8.95K | $19.78 | −$177.1K | −9.1%89.5K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Feb 4, 2025 (view filing) | Feb 3 | 1 day | Rote William E.SENIOR VICE PRESIDENT, R&D | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −8.95K | $19.78 | −$177.1K | −8.6%95.7K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Feb 10, 2025 (view filing) | Feb 6 | 4 days | Baynes Roy D.Director | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.0K | $22.00 | −$220.0K | −24.4%31.0K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Feb 12, 2025 (view filing) | Feb 12 | Same day | Inrig JulaCHIEF MEDICAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.57K | $23.53 | −$60.4K | −2.8%89.6K after | |
| Feb 12, 2025 (view filing) | Feb 11 | 1 day | Dube Eric MCHIEF EXECUTIVE OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −11.4K | $24.04 | −$273.5K | −2.6%419.2K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Feb 12, 2025 (view filing) | Feb 11-12 | 1 day | Heerma PeterCHIEF COMMERCIAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −5.64K | $24.33 | −$137.3K | −4.3%125.1K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Feb 12, 2025 (view filing) | Feb 11 | 1 day | Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −54.2K | $25.00 | −$1.36M | −49.9%54.4K after | 5 lotsThis row combines 5 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Feb 12, 2025 (view filing) | Feb 12 | Same day | Reed Elizabeth ESVP, GC & CORPORATE SECRETARY | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −8.00K | $23.53 | −$188.2K | −8.2%89.5K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Feb 12, 2025 (view filing) | Feb 12 | Same day | Rote William E.SENIOR VICE PRESIDENT, R&D | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −5.20K | $23.53 | −$122.4K | −5.0%98.5K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Apr 14, 2025 (view filing) | Apr 11 | 3 days | Cline Christopher R.CHIEF FINANCIAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −48 | $13.14 | −$630.72 | −0.1%90.0K after | |
| May 5, 2025 (view filing) | May 5 | Same day | Reed Elizabeth EChief Legal Officer and GC | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −4.92K | $21.05 | −$103.6K | −5.2%89.5K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| May 5, 2025 (view filing) | May 5 | Same day | Rote William E.Chief Research Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3.20K | $21.05 | −$67.3K | −3.1%100.2K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| May 5, 2025 (view filing) | May 5 | Same day | Heerma PeterCHIEF COMMERCIAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.77K | $21.05 | −$37.3K | −1.4%128.2K after | |
| May 5, 2025 (view filing) | May 5 | Same day | Dube Eric MCHIEF EXECUTIVE OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −18.9K | $21.05 | −$398.4K | −4.3%419.2K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| May 5, 2025 (view filing) | May 5 | Same day | Cline Christopher R.CHIEF FINANCIAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.78K | $21.05 | −$37.6K | −1.9%93.1K after | |
| Jul 2, 2025 (view filing) | Jul 1 | 1 day | Inrig JulaCHIEF MEDICAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −815 | $14.65 | −$11.9K | −0.9%88.8K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Aug 28, 2025 (view filing) | Aug 27 | 1 day | Cline Christopher R.CHIEF FINANCIAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −470 | $17.31 | −$8.14K | −0.5%92.7K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Sep 5, 2025 (view filing) | Sep 3-4 | 2 days | Cline Christopher R.CHIEF FINANCIAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −573 | $18.51 | −$10.6K | −0.6%92.1K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Sep 24, 2025 (view filing) | Sep 22 | 2 days | Reed Elizabeth EChief Legal Officer and GC | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.0K | $25.00 | −$250.0K | −10.0%89.9K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Oct 30, 2025 (view filing) | Oct 28-29 | 2 days | Dube Eric MCHIEF EXECUTIVE OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −120.0K | $30.32 | −$3.64M | −22.3%419.2K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Oct 30, 2025 (view filing) | Oct 28 | 2 days | Heerma PeterCHIEF COMMERCIAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.66K | $30.00 | −$79.9K | −2.1%124.7K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Nov 4, 2025 (view filing) | Oct 31 | 4 days | Coughlin TimothyDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −18.0K | $35.03 | −$630.5K | −24.5%55.5K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Nov 4, 2025 (view filing) | Oct 31 | 4 days | Heerma PeterCHIEF COMMERCIAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −5.59K | $35.00 | −$195.7K | −4.5%119.1K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Nov 6, 2025 (view filing) | Nov 4 | 2 days | Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −67.1K | $36.00 | −$2.42M | −58.0%48.5K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 3, 2025 (view filing) | Dec 1 | 2 days | Cline Christopher R.CHIEF FINANCIAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −20.0K | $35.01 | −$700.2K | −17.8%92.1K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 16, 2025 (view filing) | Dec 15 | 1 day | Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.91K | $36.00 | −$104.8K | −6.0%45.6K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 29, 2025 (view filing) | Dec 24 | 5 days | Rote William E.Chief Research Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −60.0K | $40.10 | −$2.41M | −37.2%101.4K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 29, 2025 (view filing) | Dec 24 | 5 days | Heerma PeterCHIEF COMMERCIAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −4.98K | $40.00 | −$199.2K | −4.2%113.0K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 29, 2025 (view filing) | Dec 24 | 5 days | Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −7.40K | $40.00 | −$296.1K | −16.2%38.2K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 29, 2025 (view filing) | Dec 24 | 5 days | Inrig JulaCHIEF MEDICAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −15.0K | $42.00 | −$630.0K | −14.5%88.8K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jan 7, 2026 (view filing) | Jan 5-6 | 2 days | Inrig JulaCHIEF MEDICAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.48K | $39.74 | −$98.4K | −2.8%86.3K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jan 21, 2026 (view filing) | Jan 20 | 1 day | Reed Elizabeth EChief Legal Officer and GC | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.0K | $27.34 | −$273.4K | −10.0%90.3K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jan 27, 2026 (view filing) | Jan 23-27 | 4 days | Dube Eric MCHIEF EXECUTIVE OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −60.0K | $30.09 | −$1.81M | −12.5%419.2K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Feb 3, 2026 (view filing) | Feb 3 | Same day | Reed Elizabeth EChief Legal Officer and GC | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −7.17K | $32.12 | −$230.5K | −6.2%108.2K after | |
| Feb 3, 2026 (view filing) | Feb 3 | Same day | Rote William E.Chief Research Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −12.4K | $32.87 | −$409.1K | −10.2%109.1K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Feb 3, 2026 (view filing) | Feb 3 | Same day | Dube Eric MCHIEF EXECUTIVE OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −100.1K | $32.28 | −$3.23M | −18.8%432.9K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Feb 3, 2026 (view filing) | Feb 3 | Same day | Heerma PeterCHIEF COMMERCIAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −7.31K | $32.12 | −$234.8K | −5.3%131.8K after | |
| Feb 3, 2026 (view filing) | Feb 3 | Same day | Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −4.33K | $32.12 | −$139.2K | −8.1%49.1K after | |
| Feb 3, 2026 (view filing) | Feb 3 | Same day | Inrig JulaCHIEF MEDICAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −6.96K | $32.12 | −$223.4K | −6.1%107.5K after | |
| Feb 3, 2026 (view filing) | Feb 3 | Same day | Cline Christopher R.CHIEF FINANCIAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −7.24K | $32.12 | −$232.6K | −6.0%113.0K after | |
| Feb 5, 2026 (view filing) | Feb 4 | 1 day | Reed Elizabeth EChief Legal Officer and GC | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.99K | $32.18 | −$96.4K | −2.8%105.2K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Feb 5, 2026 (view filing) | Feb 4 | 1 day | Inrig JulaCHIEF MEDICAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.78K | $32.21 | −$57.3K | −1.7%105.7K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Feb 5, 2026 (view filing) | Feb 4 | 1 day | Cline Christopher R.CHIEF FINANCIAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.75K | $32.19 | −$56.2K | −1.5%111.2K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Feb 19, 2026 (view filing) | Feb 17 | 2 days | Reed Elizabeth EChief Legal Officer and GC | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.0K | $27.83 | −$278.3K | −8.7%105.2K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Feb 24, 2026 (view filing) | Feb 20 | 4 days | Dube Eric MCHIEF EXECUTIVE OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −60.0K | $30.10 | −$1.81M | −12.2%432.9K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Mar 18, 2026 (view filing) | Mar 16 | 2 days | Reed Elizabeth EChief Legal Officer and GC | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.0K | $28.09 | −$280.9K | −8.7%105.2K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Apr 2, 2026 (view filing) | Apr 1 | 1 day | Reed Elizabeth EChief Legal Officer and GC | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.0K | $30.00 | −$300.0K | −8.7%105.2K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Apr 2, 2026 (view filing) | Apr 1 | 1 day | Dube Eric MCHIEF EXECUTIVE OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −60.0K | $30.93 | −$1.86M | −12.2%432.9K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Apr 7, 2026 (view filing) | Apr 6 | 1 day | Baynes Roy D.Director | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.0K | $33.00 | −$330.0K | −21.1%37.5K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Apr 15, 2026 (view filing) | Apr 14-15 | 1 day | Reed Elizabeth EChief Legal Officer and GC | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −51.5K | $41.29 | −$2.13M | −32.9%105.2K after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
