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Great Point Partners LLC

SEC CIK
0001281446
Latest filing
Aug 14, 2026

Holdings in Q4 2021

Holdings as of Dec 31, 2021, filed Feb 14, 2022. Long positions only; changes compare share counts with Q3 2021.

Institution overview
Positions
35
0 vs. Q3 2021
Portfolio value
$447.4M
+$24.5M (+5.8%) vs. Q3 2021
Filed
Feb 14, 2022
SEC
Holdings of Great Point Partners LLC in Q4 2021
SecurityClassSharesValue% of portfolioShare changeActionHistory
PNTPOINT Biopharma Global Inc.COM190,520$1.07M0.2%+190,520NewHistory
RFLRafael Holdings, Inc.COM CL B285,714$1.46M0.3%00.0%UnchangedHistory
CABACabaletta Bio, Inc.COM472,433$1.79M0.4%+472,433NewHistory
ABUSArbutus Biopharma CorpCOM668,907$2.60M0.6%+668,907NewHistory
SYRESpyre Therapeutics, Inc.COM910,251$4.32M1.0%+10,251+1.1%AddedHistory
PYXSPyxis Oncology, Inc.COMMON STOCK400,000$4.39M1.0%+400,000NewHistory
DNTHDianthus Therapeutics, Inc.COM1,170,000$5.18M1.2%00.0%UnchangedHistory
KALVKalVista Pharmaceuticals, Inc.COM411,937$5.45M1.2%+411,937NewHistory
Pieris Pharmaceuticals Inc720795103COM1,550,000$5.86M1.3%+1,550,000New–
KNSAKiniksa Pharmaceuticals International, plcCOM CL A536,738$6.32M1.4%+56,738+11.8%AddedHistory
KDNYChinook Therapeutics, Inc.COM390,041$6.36M1.4%+390,041NewHistory
URGNUroGen Pharma Ltd.COM873,424$8.31M1.9%+123,424+16.5%AddedHistory
PRQRProQR Therapeutics N.V.SHS EURO1,121,122$8.98M2.0%+1,090,786+3,595.7%AddedHistory
PASGPassage BIO, Inc.COM1,518,095$9.64M2.2%+1,518,095NewHistory
DYNDyne Therapeutics, Inc.COM845,000$10.0M2.2%+100,000+13.4%AddedHistory
SLNSilence Therapeutics plcADS444,443$10.6M2.4%+444,443NewHistory
RCKTRocket Pharmaceuticals, Inc.COM500,526$10.9M2.4%−264,474−34.6%ReducedHistory
ACRSAclaris Therapeutics, Inc.COM800,000$11.6M2.6%+300,000+60.0%AddedHistory
Avidity Biosciences, Inc.05370A108COM500,000$11.9M2.7%+500,000New–
PCVXVaxcyte, Inc.COM500,000$11.9M2.7%+401,939+409.9%AddedHistory
BCYCBicycle Therapeutics PLCSPONSORED ADS200,000$12.2M2.7%+200,000NewHistory
SRPTSarepta Therapeutics, Inc.COM145,405$13.1M2.9%+145,405NewHistory
RIGLRigel Pharmaceuticals IncCOM NEW5,000,000$13.3M3.0%+3,020,000+152.5%AddedHistory
TCDATricida, Inc.COM1,400,000$13.4M3.0%−574,000−29.1%ReducedHistory
CYTKCytokinetics IncCOM NEW350,000$16.0M3.6%−41,429−10.6%ReducedHistory
MGNXMacrogenics IncCOM1,000,000$16.1M3.6%00.0%UnchangedHistory
RLMDRelmada Therapeutics, Inc.COM717,320$16.2M3.6%+717,320NewHistory
LKFTLakefront Biotherapeutics NVSPON ADR300,000$16.5M3.7%+300,000NewHistory
BCABBioAtla, Inc.COM864,300$17.0M3.8%+20,298+2.4%AddedHistory
VRTXVertex Pharmaceuticals IncStock85,000$18.7M4.2%00.0%UnchangedHistory
ANABAnaptysbio, IncCOM592,250$20.6M4.6%+42,705+7.8%AddedHistory
TVTXTravere Therapeutics, Inc.COM800,000$24.8M5.6%+175,000+28.0%AddedHistory
XENEXenon Pharmaceuticals Inc.COM950,000$29.7M6.6%+250,000+35.7%AddedHistory
EXELExelixis, Inc.COM1,750,000$32.0M7.2%+225,000+14.8%AddedHistory
ARNAArena Pharmaceuticals IncCOM NEW530,670$49.3M11.0%00.0%UnchangedHistory

Options (1)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Great Point Partners LLC in Q4 2021
SecurityClassPutsCalls
NKTRNektar TherapeuticsCOM–$2.75M

Sold out since Q3 2021 (14)

Positions held at the end of Q3 2021 that are gone from this filing.

Positions of Great Point Partners LLC sold out since Q3 2021
SecurityClassShares in Q3 2021Value in Q3 2021% of portfolio in Q3 2021History
KDMNKadmon Holdings, Inc.COM3,375,000$29.4M7.0%History
DRNADicerna Pharmaceuticals IncCOM799,999$16.1M3.8%History
UTHRUnited Therapeutics CorpCOM86,667$16.0M3.8%History
BIIBBiogen Inc.COM47,500$13.4M3.2%History
SAGESage Therapeutics, Inc.COM269,010$11.9M2.8%History
PBYIPuma Biotechnology, Inc.COM1,300,000$9.11M2.2%History
OLMAOlema Pharmaceuticals, Inc.COM329,086$9.07M2.1%History
NKTRNektar TherapeuticsCOM504,691$9.06M2.1%History
CTMXCytomX Therapeutics, Inc.COM1,500,000$7.63M1.8%History
PHATPhathom Pharmaceuticals, Inc.COM220,863$7.09M1.7%History
RPTXRepare Therapeutics Inc.COM93,137$2.44M0.6%History
COLLCollegium Pharmaceutical, IncCOM121,342$2.40M0.6%History
FOLDAmicus Therapeutics, Inc.COM249,000$2.38M0.6%History
IFRXInflaRx N.V.COM551,918$1.43M0.3%History