| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Aug 7, 2026 | Albers Jeffrey W. | Director | M | 5,000 | $0.0000 | $0.00 |
| Aug 7, 2026 | Albers Jeffrey W. | Director | S | 10,000 | $104.6800 | $1.05M |
| Aug 7, 2026 | Albers Jeffrey W. | Director | S | 8,000 | $104.3800 | $835.04K |
| Aug 7, 2026 | Albers Jeffrey W. | Director | S | 5,000 | $104.4700 | $522.35K |
| Aug 7, 2026 | Albers Jeffrey W. | Director | M | 5,000 | $10.3900 | $51.95K |
| Aug 3, 2026 | Turtle Cameron | Chief Executive Officer | S | 16 | $97.4600 | $1.56K |
| Aug 3, 2026 | Turtle Cameron | Chief Executive Officer | S | 1,392 | $96.8200 | $134.77K |
| Aug 3, 2026 | Turtle Cameron | Chief Executive Officer | S | 5,635 | $95.9300 | $540.57K |
| Aug 3, 2026 | Turtle Cameron | Chief Executive Officer | S | 7,157 | $95.1000 | $680.63K |
| Aug 3, 2026 | Turtle Cameron | Chief Executive Officer | S | 800 | $93.9700 | $75.18K |
| Aug 3, 2026 | Burrows Scott L | Chief Financial Officer | M | 7,500 | $0.0000 | $0.00 |
| Aug 3, 2026 | Burrows Scott L | Chief Financial Officer | S | 100 | $97.1000 | $9.71K |
| Aug 3, 2026 | Burrows Scott L | Chief Financial Officer | S | 2,300 | $96.3000 | $221.49K |
| Aug 3, 2026 | Burrows Scott L | Chief Financial Officer | S | 5,100 | $95.2100 | $485.57K |
| Aug 3, 2026 | Burrows Scott L | Chief Financial Officer | M | 7,500 | $14.5000 | $108.75K |
| Jul 1, 2026 | Turtle Cameron | Chief Executive Officer | S | 590 | $88.9100 | $52.46K |
| Jul 1, 2026 | Turtle Cameron | Chief Executive Officer | S | 4,234 | $88.1200 | $373.10K |
| Jul 1, 2026 | Turtle Cameron | Chief Executive Officer | S | 10,176 | $87.4400 | $889.79K |
| Jul 1, 2026 | Sloan Sheldon | Chief Medical Officer | M | 8,334 | $0.0000 | $0.00 |
| Jul 1, 2026 | Sloan Sheldon | Chief Medical Officer | S | 1,834 | $88.3400 | $162.01K |
| Jul 1, 2026 | Sloan Sheldon | Chief Medical Officer | S | 6,500 | $87.5200 | $568.88K |
| Jul 1, 2026 | Sloan Sheldon | Chief Medical Officer | M | 8,334 | $27.4600 | $228.85K |
| Jul 1, 2026 | Burrows Scott L | Chief Financial Officer | M | 7,500 | $0.0000 | $0.00 |
| Jul 1, 2026 | Burrows Scott L | Chief Financial Officer | S | 1,725 | $88.3700 | $152.44K |
| Jul 1, 2026 | Burrows Scott L | Chief Financial Officer | S | 5,775 | $87.5500 | $505.60K |
| Jul 1, 2026 | Burrows Scott L | Chief Financial Officer | M | 7,500 | $14.5000 | $108.75K |
| Jun 25, 2026 | Burrows Scott L | Chief Financial Officer | M | 15,000 | $0.0000 | $0.00 |
| Jun 25, 2026 | Burrows Scott L | Chief Financial Officer | S | 10,000 | $87.1400 | $871.40K |
| Jun 25, 2026 | Burrows Scott L | Chief Financial Officer | S | 5,000 | $87.1200 | $435.60K |
| Jun 25, 2026 | Burrows Scott L | Chief Financial Officer | M | 15,000 | $14.5000 | $217.50K |
| Jun 23, 2026 | Fairmount Funds Management LLC | Director | C | 666,680 | $0.0000 | $0.00 |
| Jun 23, 2026 | Fairmount Funds Management LLC | Director | S | 4,684,781 | $85.3100 | $399.66M |
| Jun 23, 2026 | Fairmount Funds Management LLC | Director | C | 666,680 | – | – |
| Jun 22, 2026 | HENDERSON MICHAEL THOMAS | Director | S | 20,000 | $100.0000 | $2.00M |
| Jun 3, 2026 | Sloan Sheldon | Chief Medical Officer | M | 8,333 | $0.0000 | $0.00 |
| Jun 3, 2026 | Sloan Sheldon | Chief Medical Officer | S | 8,333 | $75.0000 | $624.98K |
| Jun 3, 2026 | Sloan Sheldon | Chief Medical Officer | M | 8,333 | $27.4600 | $228.82K |
| Jun 1, 2026 | Burrows Scott L | Chief Financial Officer | M | 7,500 | $0.0000 | $0.00 |
| Jun 1, 2026 | Burrows Scott L | Chief Financial Officer | S | 3,100 | $72.0600 | $223.39K |
| Jun 1, 2026 | Burrows Scott L | Chief Financial Officer | S | 2,599 | $70.7700 | $183.93K |
| Jun 1, 2026 | Burrows Scott L | Chief Financial Officer | S | 1,801 | $69.7500 | $125.62K |
| Jun 1, 2026 | Burrows Scott L | Chief Financial Officer | M | 7,500 | $14.5000 | $108.75K |
| Jun 1, 2026 | Turtle Cameron | Chief Executive Officer | S | 3,294 | $71.3800 | $235.13K |
| Jun 1, 2026 | Turtle Cameron | Chief Executive Officer | S | 8,149 | $70.5000 | $574.50K |
| Jun 1, 2026 | Turtle Cameron | Chief Executive Officer | S | 3,557 | $69.4000 | $246.85K |
| May 27, 2026 | McKenna Mark C. | Director | A | 8,026 | $0.0000 | $0.00 |
| May 27, 2026 | Milligan Sandra | Director | A | 8,026 | $0.0000 | $0.00 |
| May 27, 2026 | Stelzer Laurie | Director | A | 8,026 | $0.0000 | $0.00 |
| May 27, 2026 | HENDERSON MICHAEL THOMAS | Director | A | 8,026 | $0.0000 | $0.00 |
| May 27, 2026 | Albers Jeffrey W. | Director | A | 8,026 | $0.0000 | $0.00 |