| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Aug 13, 2026 | Johnson Paula A | Director | A | 36,000 | $0.0000 | $0.00 |
| Aug 13, 2026 | Kornowski Sophie | Director | A | 36,000 | $0.0000 | $0.00 |
| Aug 13, 2026 | Bernstein Harold | President, R&D & CMO | M | 16,142 | $0.0000 | $0.00 |
| Aug 13, 2026 | Bernstein Harold | President, R&D & CMO | S | 16,142 | $27.6063 | $445.62K |
| Aug 13, 2026 | Bernstein Harold | President, R&D & CMO | M | 16,142 | $10.4200 | $168.20K |
| Aug 3, 2026 | Coloma Jason V | Chief Executive Officer | S | 1,604 | $27.0853 | $43.44K |
| Aug 3, 2026 | Coloma Jason V | Chief Executive Officer | S | 30,304 | $26.7140 | $809.54K |
| Aug 3, 2026 | Coloma Jason V | Chief Executive Officer | S | 154 | $27.0940 | $4.17K |
| Aug 3, 2026 | Coloma Jason V | Chief Executive Officer | S | 2,439 | $26.7145 | $65.16K |
| Jul 29, 2026 | Dandekar Atul | CSBO | M | 7,500 | $0.0000 | $0.00 |
| Jul 29, 2026 | Dandekar Atul | CSBO | S | 400 | $27.8900 | $11.16K |
| Jul 29, 2026 | Dandekar Atul | CSBO | S | 7,100 | $27.3064 | $193.88K |
| Jul 29, 2026 | Dandekar Atul | CSBO | M | 7,500 | $10.4200 | $78.15K |
| Jul 1, 2026 | Coloma Jason V | Chief Executive Officer | S | 1,597 | $30.4359 | $48.61K |
| Jul 1, 2026 | Coloma Jason V | Chief Executive Officer | S | 30,311 | $29.9535 | $907.92K |
| Jul 1, 2026 | Coloma Jason V | Chief Executive Officer | S | 2,593 | $29.9754 | $77.73K |
| Jul 1, 2026 | Bernstein Harold | President, R&D & CMO | M | 14,609 | $0.0000 | $0.00 |
| Jul 1, 2026 | Bernstein Harold | President, R&D & CMO | S | 1,200 | $30.3369 | $36.40K |
| Jul 1, 2026 | Bernstein Harold | President, R&D & CMO | S | 13,409 | $29.8650 | $400.46K |
| Jul 1, 2026 | Bernstein Harold | President, R&D & CMO | M | 14,609 | $10.4200 | $152.22K |
| Jun 29, 2026 | Dandekar Atul | CSBO | M | 7,500 | $0.0000 | $0.00 |
| Jun 29, 2026 | Dandekar Atul | CSBO | S | 7,500 | $28.0200 | $210.15K |
| Jun 29, 2026 | Dandekar Atul | CSBO | M | 7,500 | $10.4200 | $78.15K |
| Jun 23, 2026 | Coloma Jason V | Chief Executive Officer | S | 23,865 | $26.0496 | $621.67K |
| Jun 22, 2026 | Coloma Jason V | Chief Executive Officer | S | 2,040 | $26.0000 | $53.04K |
| Jun 22, 2026 | Coloma Jason V | Chief Executive Officer | S | 1,953 | $26.0015 | $50.78K |
| Jun 8, 2026 | Andrews Nancy C | Director | A | 18,000 | $0.0000 | $0.00 |
| Jun 8, 2026 | HOMCY CHARLES J | Director | A | 18,000 | $0.0000 | $0.00 |
| Jun 8, 2026 | Hoppenot Herve | Director | A | 18,000 | $0.0000 | $0.00 |
| Jun 8, 2026 | Lim Jonathan E | Director | A | 18,000 | $0.0000 | $0.00 |
| Jun 8, 2026 | SCHELLER RICHARD H | Director | A | 18,000 | $0.0000 | $0.00 |
| Jun 8, 2026 | SPIEGELMAN DANIEL K | Director | A | 18,000 | $0.0000 | $0.00 |
| Jun 1, 2026 | Bernstein Harold | President, R&D & CMO | M | 14,853 | $0.0000 | $0.00 |
| Jun 1, 2026 | Bernstein Harold | President, R&D & CMO | S | 1,600 | $26.3576 | $42.17K |
| Jun 1, 2026 | Bernstein Harold | President, R&D & CMO | S | 13,253 | $25.5746 | $338.94K |
| Jun 1, 2026 | Bernstein Harold | President, R&D & CMO | M | 14,853 | $10.4200 | $154.77K |
| Jun 1, 2026 | Coloma Jason V | Chief Executive Officer | S | 553 | $26.2412 | $14.51K |
| Jun 1, 2026 | Coloma Jason V | Chief Executive Officer | S | 6,090 | $26.1965 | $159.54K |
| May 29, 2026 | Dandekar Atul | CSBO | M | 7,500 | $0.0000 | $0.00 |
| May 29, 2026 | Dandekar Atul | CSBO | S | 7,500 | $26.3405 | $197.55K |
| May 29, 2026 | Dandekar Atul | CSBO | M | 7,500 | $10.4200 | $78.15K |
| May 26, 2026 | Coloma Jason V | Chief Executive Officer | S | 25,582 | $26.0150 | $665.51K |
| May 22, 2026 | Coloma Jason V | Chief Executive Officer | S | 2,478 | $26.0000 | $64.43K |
| May 22, 2026 | Coloma Jason V | Chief Executive Officer | S | 4,504 | $26.0001 | $117.10K |
| May 15, 2026 | Coloma Jason V | Chief Executive Officer | S | 116 | $26.0000 | $3.02K |
| May 15, 2026 | Coloma Jason V | Chief Executive Officer | S | 1,822 | $26.0000 | $47.37K |
| May 14, 2026 | Bernstein Harold | President, R&D & CMO | M | 15,000 | $0.0000 | $0.00 |
| May 14, 2026 | Bernstein Harold | President, R&D & CMO | S | 15,000 | $26.2236 | $393.35K |
| May 14, 2026 | Bernstein Harold | President, R&D & CMO | M | 15,000 | $10.4200 | $156.30K |
| May 4, 2026 | HOMCY CHARLES J | Director | G | 7,422 | $0.0000 | $0.00 |