| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Aug 20, 2026 | Rielly-Gauvin Katherine | Director | M | 6,666 | $0.0000 | $0.00 |
| Aug 20, 2026 | Rielly-Gauvin Katherine | Director | M | 11,727 | $0.0000 | $0.00 |
| Aug 20, 2026 | Rielly-Gauvin Katherine | Director | S | 18,393 | $72.2273 | $1.33M |
| Aug 20, 2026 | Rielly-Gauvin Katherine | Director | M | 6,666 | $2.5900 | $17.26K |
| Aug 20, 2026 | Rielly-Gauvin Katherine | Director | M | 11,727 | $2.5100 | $29.43K |
| Aug 19, 2026 | Rielly-Gauvin Katherine | Director | M | 13,334 | $0.0000 | $0.00 |
| Aug 19, 2026 | Rielly-Gauvin Katherine | Director | M | 23,455 | $0.0000 | $0.00 |
| Aug 19, 2026 | Rielly-Gauvin Katherine | Director | S | 36,789 | $74.9941 | $2.76M |
| Aug 19, 2026 | Rielly-Gauvin Katherine | Director | M | 13,334 | $2.5900 | $34.53K |
| Aug 19, 2026 | Rielly-Gauvin Katherine | Director | M | 23,455 | $2.5100 | $58.87K |
| Aug 19, 2026 | Saggar Rajeev | Chief Medical Officer | M | 50,000 | $0.0000 | $0.00 |
| Aug 19, 2026 | Saggar Rajeev | Chief Medical Officer | S | 50,000 | $74.0565 | $3.70M |
| Aug 19, 2026 | Saggar Rajeev | Chief Medical Officer | M | 50,000 | $3.7300 | $186.50K |
| Aug 17, 2026 | Saggar Rajeev | Chief Medical Officer | S | 29,534 | $76.8396 | $2.27M |
| Jul 27, 2026 | Adair Jason | Chief Business Officer | S | 688 | $87.5300 | $60.22K |
| Jul 27, 2026 | Boyle Dana | Chief Accounting Officer | S | 1,600 | $87.5300 | $140.05K |
| Jul 23, 2026 | Bloch Stephen M | Director | S | 3,600 | $90.7065 | $326.54K |
| Jul 23, 2026 | Bloch Stephen M | Director | S | 96,400 | $89.4388 | $8.62M |
| Jul 22, 2026 | Bloch Stephen M | Director | S | 14,562 | $89.2425 | $1.30M |
| Jul 22, 2026 | Bloch Stephen M | Director | S | 48,032 | $88.6461 | $4.26M |
| Jul 22, 2026 | Bloch Stephen M | Director | S | 37,406 | $87.7016 | $3.28M |
| Jul 21, 2026 | Bloch Stephen M | Director | S | 556 | $80.6576 | $44.84K |
| Jul 21, 2026 | Bloch Stephen M | Director | S | 74,444 | $79.9841 | $5.95M |
| Jul 20, 2026 | Bloch Stephen M | Director | S | 3,596 | $79.5518 | $286.07K |
| Jul 13, 2026 | Boyle Dana | Chief Accounting Officer | S | 8,361 | $71.5200 | $597.98K |
| Jul 13, 2026 | Boyle Dana | Chief Accounting Officer | S | 641 | $71.3900 | $45.76K |
| Jul 13, 2026 | Schundler Russell | General Counsel | S | 13,692 | $71.5200 | $979.25K |
| Jul 13, 2026 | Schundler Russell | General Counsel | S | 1,046 | $71.3900 | $74.67K |
| Jul 13, 2026 | JEFFS ROGER | Chief Executive Officer | S | 32,744 | $71.5200 | $2.34M |
| Jul 13, 2026 | JEFFS ROGER | Chief Executive Officer | S | 2,505 | $71.3900 | $178.83K |
| Jul 13, 2026 | Moomaw Scott | Chief Commercial Officer | S | 8,864 | $71.5200 | $633.95K |
| Jul 13, 2026 | Moomaw Scott | Chief Commercial Officer | S | 675 | $71.3900 | $48.19K |
| Jul 13, 2026 | Saggar Rajeev | Chief Medical Officer | S | 9,223 | $71.5200 | $659.63K |
| Jul 13, 2026 | Saggar Rajeev | Chief Medical Officer | S | 703 | $71.3900 | $50.19K |
| Jul 13, 2026 | Adair Jason | Chief Business Officer | S | 7,301 | $71.5200 | $522.17K |
| Jul 13, 2026 | Adair Jason | Chief Business Officer | S | 562 | $71.3900 | $40.12K |
| Jul 13, 2026 | Kaseta Michael | CFO and COO | S | 18,977 | $71.5200 | $1.36M |
| Jul 13, 2026 | Kaseta Michael | CFO and COO | S | 1,453 | $71.3900 | $103.73K |
| Jul 13, 2026 | Khindri Sanjeev | Chief Development Officer | S | 1,101 | $71.5200 | $78.74K |
| Jul 13, 2026 | Khindri Sanjeev | Chief Development Officer | S | 84 | $71.3900 | $6.00K |
| Jul 13, 2026 | Krepp Sarah | Chief Human Resource Officer | S | 7,306 | $71.5200 | $522.52K |
| Jul 13, 2026 | Krepp Sarah | Chief Human Resource Officer | S | 558 | $71.3900 | $39.84K |
| Jul 10, 2026 | Boyle Dana | Chief Accounting Officer | M | 3,179 | $0.0000 | $0.00 |
| Jul 10, 2026 | Boyle Dana | Chief Accounting Officer | M | 3,179 | – | – |
| Jul 10, 2026 | Schundler Russell | General Counsel | M | 6,409 | $0.0000 | $0.00 |
| Jul 10, 2026 | Schundler Russell | General Counsel | M | 3,759 | $0.0000 | $0.00 |
| Jul 10, 2026 | Schundler Russell | General Counsel | M | 6,409 | – | – |
| Jul 10, 2026 | Schundler Russell | General Counsel | M | 3,759 | – | – |
| Jul 10, 2026 | JEFFS ROGER | Chief Executive Officer | M | 14,333 | $0.0000 | $0.00 |
| Jul 10, 2026 | JEFFS ROGER | Chief Executive Officer | M | 13,834 | $0.0000 | $0.00 |