| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Aug 18, 2026 | Cho Esther | Chief Legal Officer | S | 4,485 | $10.2900 | $46.15K |
| Aug 18, 2026 | Newton Charles W. | Director | S | 551 | $10.3000 | $5.67K |
| Aug 18, 2026 | Lerner Lorena Raquel | Chief Scientific Officer | S | 3,568 | $10.2900 | $36.71K |
| Aug 18, 2026 | Tanini Annita | Corp. Controller & VP, Finance | S | 1,224 | $10.2900 | $12.59K |
| Aug 17, 2026 | BIENAIME JEAN JACQUES | Director | P | 1,000 | $10.2700 | $10.27K |
| Jul 15, 2026 | BIENAIME JEAN JACQUES | Director | P | 1,000 | $10.6100 | $10.61K |
| Jul 1, 2026 | Prener Anne | Director | A | 14,870 | $0.0000 | $0.00 |
| Jul 1, 2026 | Prener Anne | Director | A | 13,786 | $0.0000 | $0.00 |
| Jun 15, 2026 | BIENAIME JEAN JACQUES | Director | P | 1,000 | $10.1900 | $10.19K |
| Jun 11, 2026 | Newton Charles W. | Director | S | 550 | $10.0400 | $5.52K |
| Jun 4, 2026 | Knowles Julius | Director | S | 2,625 | $10.7300 | $28.17K |
| Jun 4, 2026 | Farzan Nima | Director | S | 2,625 | $10.7300 | $28.17K |
| Jun 4, 2026 | Seth Alpna | Director | S | 2,625 | $10.7200 | $28.14K |
| Jun 3, 2026 | Knowles Julius | Director | A | 7,433 | $0.0000 | $0.00 |
| Jun 3, 2026 | Knowles Julius | Director | A | 7,142 | $0.0000 | $0.00 |
| Jun 3, 2026 | BIENAIME JEAN JACQUES | Director | A | 7,433 | $0.0000 | $0.00 |
| Jun 3, 2026 | BIENAIME JEAN JACQUES | Director | A | 7,142 | $0.0000 | $0.00 |
| Jun 3, 2026 | Farzan Nima | Director | A | 7,433 | $0.0000 | $0.00 |
| Jun 3, 2026 | Farzan Nima | Director | A | 7,142 | $0.0000 | $0.00 |
| Jun 3, 2026 | GRAY MARY ANN | Director | A | 7,433 | $0.0000 | $0.00 |
| Jun 3, 2026 | GRAY MARY ANN | Director | A | 7,142 | $0.0000 | $0.00 |
| Jun 3, 2026 | Seth Alpna | Director | A | 7,433 | $0.0000 | $0.00 |
| Jun 3, 2026 | Seth Alpna | Director | A | 7,142 | $0.0000 | $0.00 |
| May 15, 2026 | BIENAIME JEAN JACQUES | Director | P | 1,000 | $10.5800 | $10.58K |
| Apr 15, 2026 | BIENAIME JEAN JACQUES | Director | P | 1,000 | $11.7000 | $11.70K |
| Apr 2, 2026 | Seehra Jasbir | CHIEF EXECUTIVE OFFICER | M | 55,000 | $0.0000 | $0.00 |
| Apr 2, 2026 | Seehra Jasbir | CHIEF EXECUTIVE OFFICER | M | 55,000 | $0.3000 | $16.50K |
| Mar 9, 2026 | BIENAIME JEAN JACQUES | Director | P | 2,000 | $11.2100 | $22.42K |
| Mar 9, 2026 | Newton Charles W. | Director | A | 14,788 | $0.0000 | $0.00 |
| Mar 9, 2026 | Newton Charles W. | Director | A | 13,215 | $0.0000 | $0.00 |
| Feb 24, 2026 | Cho Esther | Chief Legal Officer | A | 80,000 | $0.0000 | $0.00 |
| Feb 24, 2026 | Regnante Keith | CHIEF FINANCIAL OFFICER | A | 60,000 | $0.0000 | $0.00 |
| Feb 24, 2026 | Lerner Lorena Raquel | Chief Scientific Officer | A | 75,000 | $0.0000 | $0.00 |
| Feb 24, 2026 | Seehra Jasbir | CHIEF EXECUTIVE OFFICER | A | 100,000 | $0.0000 | $0.00 |
| Feb 24, 2026 | Seehra Jasbir | CHIEF EXECUTIVE OFFICER | A | 217,000 | $0.0000 | $0.00 |
| Feb 24, 2026 | Cho Esther | Chief Legal Officer | A | 80,000 | $0.0000 | $0.00 |
| Feb 19, 2026 | Seehra Jasbir | CHIEF EXECUTIVE OFFICER | S | 7,015 | $16.1700 | $113.43K |
| Feb 18, 2026 | Regnante Keith | CHIEF FINANCIAL OFFICER | S | 4,739 | $16.3500 | $77.48K |
| Feb 18, 2026 | Cho Esther | SVP, General Counsel | S | 4,745 | $16.3500 | $77.58K |
| Feb 18, 2026 | Lerner Lorena Raquel | Chief Science Officer | S | 3,873 | $16.3500 | $63.32K |
| Jan 7, 2026 | Seehra Jasbir | CHIEF EXECUTIVE OFFICER | A | 62,500 | $0.0000 | $0.00 |
| Nov 21, 2025 | Knowles Julius | Director | D | 130,494 | $17.7500 | $2.32M |
| Nov 21, 2025 | Knowles Julius | Director | D | 191,527 | $17.7500 | $3.40M |
| Nov 21, 2025 | GORDON CARL L | Director | D | 74,465 | $17.7500 | $1.32M |
| Nov 21, 2025 | GORDON CARL L | Director | D | 140,057 | $17.7500 | $2.49M |
| Nov 21, 2025 | ORBIMED ADVISORS LLC | Director | D | 74,465 | $17.7500 | $1.32M |
| Nov 21, 2025 | ORBIMED ADVISORS LLC | Director | D | 140,057 | $17.7500 | $2.49M |
| Oct 15, 2025 | ADAR1 Capital Management, LLC | 10% Owner | S | 743,358 | $17.7500 | $13.19M |
| Oct 15, 2025 | ADAR1 Capital Management, LLC | 10% Owner | S | 254,669 | $17.7500 | $4.52M |
| Oct 15, 2025 | ADAR1 Capital Management, LLC | 10% Owner | S | 4,391,237 | $17.7500 | $77.94M |