| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jul 31, 2026 | Hayden Michael R | Director | P | 5,000 | $51.6000 | $258.00K |
| Jul 30, 2026 | Hayden Michael R | Director | P | 15,000 | $53.3800 | $800.70K |
| Jul 15, 2026 | HERMAN JOAN E | Director | M | 5,220 | $0.0000 | $0.00 |
| Jul 15, 2026 | HERMAN JOAN E | Director | M | 5,220 | $0.0000 | $0.00 |
| Jul 15, 2026 | BERTHELSEN SPENCER R | Director | M | 5,220 | $0.0000 | $0.00 |
| Jul 15, 2026 | BERTHELSEN SPENCER R | Director | M | 5,220 | $0.0000 | $0.00 |
| Jul 15, 2026 | HANTSON LUDWIG | Director | A | 3,399 | $0.0000 | $0.00 |
| Jul 15, 2026 | Reikes Peter N | Director | A | 3,399 | $0.0000 | $0.00 |
| Jul 7, 2026 | Kordasiewicz Holly B. | EVP, Chief Development Officer | S | 362 | $84.3000 | $30.52K |
| Jul 7, 2026 | Diaz Allene M. | Director | M | 10,111 | $0.0000 | $0.00 |
| Jul 7, 2026 | Diaz Allene M. | Director | S | 10,111 | $85.4156 | $863.64K |
| Jul 7, 2026 | Diaz Allene M. | Director | M | 10,111 | $47.1100 | $476.33K |
| Jul 7, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | J | 15,000 | $0.0000 | $0.00 |
| Jul 7, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | 15,000 | $85.4620 | $1.28M |
| Jul 7, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | J | 15,000 | $0.0000 | $0.00 |
| Jul 7, 2026 | BENNETT C FRANK | EVP, Chief Scientific Officer | S | 5,536 | $83.5790 | $462.69K |
| Jul 1, 2026 | BERTHELSEN SPENCER R | Director | A | 2,301 | $0.0000 | $0.00 |
| Jul 1, 2026 | BERTHELSEN SPENCER R | Director | A | 5,369 | $0.0000 | $0.00 |
| Jul 1, 2026 | Diaz Allene M. | Director | A | 2,301 | $0.0000 | $0.00 |
| Jul 1, 2026 | Diaz Allene M. | Director | A | 5,369 | $0.0000 | $0.00 |
| Jul 1, 2026 | Hayden Michael R | Director | A | 2,301 | $0.0000 | $0.00 |
| Jul 1, 2026 | Hayden Michael R | Director | A | 5,369 | $0.0000 | $0.00 |
| Jul 1, 2026 | KLEIN JOSEPH III | Director | A | 2,301 | $0.0000 | $0.00 |
| Jul 1, 2026 | KLEIN JOSEPH III | Director | A | 5,369 | $0.0000 | $0.00 |
| Jul 1, 2026 | KLEIN JOSEPH III | Director | M | 11,518 | $0.0000 | $0.00 |
| Jul 1, 2026 | KLEIN JOSEPH III | Director | S | 11,419 | $79.0394 | $902.55K |
| Jul 1, 2026 | KLEIN JOSEPH III | Director | S | 99 | $79.4500 | $7.87K |
| Jul 1, 2026 | KLEIN JOSEPH III | Director | M | 11,518 | $39.9400 | $460.03K |
| Jul 1, 2026 | HERMAN JOAN E | Director | A | 2,301 | $0.0000 | $0.00 |
| Jul 1, 2026 | HERMAN JOAN E | Director | A | 5,369 | $0.0000 | $0.00 |
| Jul 1, 2026 | LOSCALZO JOSEPH | Director | A | 2,301 | $0.0000 | $0.00 |
| Jul 1, 2026 | LOSCALZO JOSEPH | Director | A | 5,369 | $0.0000 | $0.00 |
| Jul 1, 2026 | YANG MICHAEL J. | Director | A | 2,301 | $0.0000 | $0.00 |
| Jul 1, 2026 | YANG MICHAEL J. | Director | A | 5,369 | $0.0000 | $0.00 |
| Jun 26, 2026 | O'NEIL PATRICK R. | EVP CLO & General Counsel | S | 3,069 | $80.0000 | $245.52K |
| Jun 26, 2026 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | M | 26,000 | $0.0000 | $0.00 |
| Jun 26, 2026 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | S | 26,000 | $81.0460 | $2.11M |
| Jun 26, 2026 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | M | 26,000 | $60.8900 | $1.58M |
| Jun 26, 2026 | Baroldi Joseph | EVP, Chief Business Officer | M | 3,866 | $0.0000 | $0.00 |
| Jun 26, 2026 | Baroldi Joseph | EVP, Chief Business Officer | M | 1,769 | $0.0000 | $0.00 |
| Jun 26, 2026 | Baroldi Joseph | EVP, Chief Business Officer | S | 5,635 | $80.1595 | $451.70K |
| Jun 26, 2026 | Baroldi Joseph | EVP, Chief Business Officer | M | 1,769 | $32.6000 | $57.67K |
| Jun 26, 2026 | Baroldi Joseph | EVP, Chief Business Officer | M | 3,866 | $56.7800 | $219.51K |
| Jun 26, 2026 | Monia Brett P | Chief Executive Officer | M | 50,000 | $0.0000 | $0.00 |
| Jun 26, 2026 | Monia Brett P | Chief Executive Officer | S | 50,000 | $80.5900 | $4.03M |
| Jun 26, 2026 | Monia Brett P | Chief Executive Officer | M | 50,000 | $56.7800 | $2.84M |
| Jun 25, 2026 | Monia Brett P | Chief Executive Officer | M | 21,072 | $0.0000 | $0.00 |
| Jun 25, 2026 | Monia Brett P | Chief Executive Officer | S | 21,072 | $78.4900 | $1.65M |
| Jun 25, 2026 | Monia Brett P | Chief Executive Officer | M | 21,072 | $32.6000 | $686.95K |
| Jun 25, 2026 | Swayze Eric | EVP Research | S | 10,602 | $79.1824 | $839.49K |