| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Aug 14, 2026 | Yarema Kristin | Chief Executive Officer | A | 250,000 | $0.0000 | $0.00 |
| Aug 14, 2026 | Yarema Kristin | Chief Executive Officer | A | 137,200 | $0.0000 | $0.00 |
| Aug 14, 2026 | Yarema Kristin | Chief Executive Officer | A | 254,800 | $0.0000 | $0.00 |
| Aug 14, 2026 | Grant-Huerta Yanina | Chief Financial Officer | A | 56,000 | $0.0000 | $0.00 |
| Aug 14, 2026 | Grant-Huerta Yanina | Chief Financial Officer | A | 39,000 | $0.0000 | $0.00 |
| Aug 14, 2026 | Grant-Huerta Yanina | Chief Financial Officer | A | 65,000 | $0.0000 | $0.00 |
| Jul 25, 2026 | Yarema Kristin | Chief Executive Officer | J | 115,129 | $0.0000 | $0.00 |
| Jul 25, 2026 | Yarema Kristin | Chief Executive Officer | M | 38,376 | $0.0000 | $0.00 |
| Jul 25, 2026 | Yarema Kristin | Chief Executive Officer | J | 115,129 | $0.0000 | $0.00 |
| Jul 25, 2026 | Yarema Kristin | Chief Executive Officer | M | 38,376 | $0.0000 | $0.00 |
| Jul 17, 2026 | Lally Robert B | Principal Accounting Officer | S | 1,525 | $5.3400 | $8.14K |
| Jul 16, 2026 | Lally Robert B | Principal Accounting Officer | S | 1,671 | $5.5000 | $9.19K |
| Jun 16, 2026 | Bonita David P | Director | A | 15,600 | $0.0000 | $0.00 |
| Jun 16, 2026 | Wang Jonathan Jian | Director | A | 15,600 | $0.0000 | $0.00 |
| Jun 16, 2026 | SLATTERY JOSEPH P | Director | A | 15,600 | $0.0000 | $0.00 |
| Jun 16, 2026 | Stampacchia Otello | Director | A | 15,600 | $0.0000 | $0.00 |
| Apr 14, 2026 | ORBIMED ADVISORS LLC | Director | P | 384,689 | – | – |
| Apr 14, 2026 | ORBIMED ADVISORS LLC | Director | P | 336,603 | – | – |
| Apr 14, 2026 | Bonita David P | Director | P | 384,689 | – | – |
| Apr 14, 2026 | Bonita David P | Director | P | 336,603 | – | – |
| Mar 16, 2026 | Yarema Kristin | Chief Executive Officer | A | 128,100 | $0.0000 | $0.00 |
| Mar 16, 2026 | Yarema Kristin | Chief Executive Officer | A | 85,400 | $0.0000 | $0.00 |
| Dec 30, 2025 | Butler Erin | Principal Accounting Officer | A | 22,500 | $0.0000 | $0.00 |
| Dec 30, 2025 | Butler Erin | Principal Accounting Officer | A | 22,500 | $0.0000 | $0.00 |
| Dec 24, 2025 | SLATTERY JOSEPH P | Director | P | 16,000 | $5.9900 | $95.84K |
| Dec 18, 2025 | SLATTERY JOSEPH P | Director | A | 31,200 | $0.0000 | $0.00 |
| Dec 18, 2025 | Wang Stephen Hui | Director | A | 31,200 | $0.0000 | $0.00 |
| Dec 18, 2025 | Wang Jonathan Jian | Director | A | 31,200 | $0.0000 | $0.00 |
| Jul 28, 2025 | Marango Jotin | Chief Financial Officer | F | 4,630 | $17.1600 | $79.45K |
| Jul 28, 2025 | Marango Jotin | Chief Financial Officer | A | 15,776 | – | – |
| Jul 28, 2025 | Yarema Kristin | Chief Executive Officer | A | 153,505 | $0.0000 | $0.00 |
| Jul 28, 2025 | Yarema Kristin | Chief Executive Officer | A | 460,515 | $0.0000 | $0.00 |
| Jul 25, 2025 | Butler Erin | Principal Accounting Officer | A | 3,813 | – | – |
| Jul 25, 2025 | Butler Erin | Principal Accounting Officer | A | 3,051 | – | – |
| Jul 25, 2025 | Marango Jotin | Chief Financial Officer | D | 397,199 | $0.0000 | $0.00 |
| Jul 25, 2025 | Marango Jotin | Chief Financial Officer | D | 105,000 | $0.0000 | $0.00 |
| Jul 25, 2025 | Marango Jotin | Chief Financial Officer | D | 181,000 | $0.0000 | $0.00 |
| Jul 25, 2025 | Stampacchia Otello | Director | M | 17,520 | $0.0000 | $0.00 |
| Jul 25, 2025 | Stampacchia Otello | Director | P | 267,556 | $29.9000 | $8.00M |
| Jul 25, 2025 | Stampacchia Otello | Director | M | 379 | – | – |
| Jul 25, 2025 | Bonita David P | Director | M | 17,520 | $0.0000 | $0.00 |
| Jul 25, 2025 | Bonita David P | Director | P | 83,611 | $29.9000 | $2.50M |
| Jul 25, 2025 | Bonita David P | Director | M | 379 | – | – |
| Jul 25, 2025 | ORBIMED ADVISORS LLC | Director | A | 83,611 | $2.4900 | $208.19K |
| Jul 25, 2025 | Lu Yufang | Chief Medical Officer | A | 6,102 | – | – |
| Jul 25, 2025 | Lu Yufang | Chief Medical Officer | A | 4,591 | – | – |
| Jul 25, 2025 | Lu Yufang | Chief Medical Officer | A | 27,459 | – | – |
| Jul 25, 2025 | Lu Yufang | Chief Medical Officer | A | 38,137 | – | – |
| Jul 25, 2025 | Wang Jonathan Jian | Director | A | 971,173 | – | – |
| Jul 25, 2025 | Wang Jonathan Jian | Director | A | 143,832 | – | – |