| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Aug 20, 2026 | BRYNJELSEN SEAN | President & CEO | S | 7,342 | $62.1200 | $456.08K |
| Aug 20, 2026 | BRYNJELSEN SEAN | President & CEO | S | 36,373 | $61.1100 | $2.22M |
| Aug 20, 2026 | BRYNJELSEN SEAN | President & CEO | S | 47,307 | $60.1700 | $2.85M |
| Aug 19, 2026 | BRYNJELSEN SEAN | President & CEO | S | 8,978 | $62.6500 | $562.47K |
| Jul 31, 2026 | Adams Jennifer McKie | Director | A | 10,000 | $0.0000 | $0.00 |
| Jul 31, 2026 | RIEDEL NORBERT G | Director | A | 10,000 | $0.0000 | $0.00 |
| Jul 31, 2026 | MAIER PAUL V | Director | A | 10,000 | $0.0000 | $0.00 |
| Jul 31, 2026 | Krempa David | Chief Business Officer | A | 128,985 | $0.0000 | $0.00 |
| Jul 31, 2026 | BRYNJELSEN SEAN | President & CEO | A | 128,985 | $0.0000 | $0.00 |
| Jul 31, 2026 | Erdogan-Trinkaus Ipek | Chief Commercial Officer | A | 80,000 | $0.0000 | $0.00 |
| Jul 31, 2026 | Matthews Judith M. | Chief Financial Officer | A | 32,246 | $0.0000 | $0.00 |
| Jul 31, 2026 | CASAMENTO CHARLES J | Director | A | 10,000 | $0.0000 | $0.00 |
| Jul 14, 2026 | Opaleye Management Inc. | 10% Owner | S | 13,315 | $37.5431 | $499.89K |
| Jul 14, 2026 | Opaleye Management Inc. | 10% Owner | S | 15,000 | $37.5431 | $563.15K |
| Jul 14, 2026 | Opaleye Management Inc. | 10% Owner | S | 13,315 | $37.5431 | $499.89K |
| Jul 14, 2026 | Opaleye Management Inc. | 10% Owner | S | 15,000 | $37.5431 | $563.15K |
| Jul 14, 2026 | BRYNJELSEN SEAN | President & CEO | M | 200,000 | $0.0000 | $0.00 |
| Jul 14, 2026 | BRYNJELSEN SEAN | President & CEO | M | 200,000 | $1.3700 | $274.00K |
| Jul 12, 2026 | BRYNJELSEN SEAN | President & CEO | M | 27,500 | $0.0000 | $0.00 |
| Jul 12, 2026 | BRYNJELSEN SEAN | President & CEO | M | 27,500 | – | – |
| Jul 12, 2026 | Krempa David | Chief Business Officer | M | 10,000 | $0.0000 | $0.00 |
| Jul 12, 2026 | Krempa David | Chief Business Officer | M | 10,000 | – | – |
| Jul 7, 2026 | Opaleye Management Inc. | 10% Owner | S | 6,685 | $38.3728 | $256.52K |
| Jul 7, 2026 | Opaleye Management Inc. | 10% Owner | S | 20,000 | $38.3728 | $767.46K |
| Jul 6, 2026 | Opaleye Management Inc. | 10% Owner | S | 10,000 | $38.0000 | $380.00K |
| Jul 2, 2026 | Opaleye Management Inc. | 10% Owner | S | 25,000 | $37.3851 | $934.63K |
| Jul 2, 2026 | Opaleye Management Inc. | 10% Owner | S | 65,000 | $37.3851 | $2.43M |
| Jun 26, 2026 | Krempa David | Chief Business Officer | A | 10,000 | $0.0000 | $0.00 |
| Jun 17, 2026 | Adams Jennifer McKie | Director | M | 50,000 | $0.0000 | $0.00 |
| Jun 17, 2026 | Adams Jennifer McKie | Director | S | 50,000 | $32.4759 | $1.62M |
| Jun 17, 2026 | Adams Jennifer McKie | Director | M | 50,000 | $3.7800 | $189.00K |
| May 28, 2026 | BRYNJELSEN SEAN | President & CEO | S | 148 | $32.6700 | $4.83K |
| May 28, 2026 | BRYNJELSEN SEAN | President & CEO | S | 119,852 | $31.8800 | $3.82M |
| May 27, 2026 | Krempa David | Chief Business Officer | M | 7,203 | $0.0000 | $0.00 |
| May 27, 2026 | Krempa David | Chief Business Officer | M | 12,476 | $0.0000 | $0.00 |
| May 27, 2026 | Krempa David | Chief Business Officer | S | 19,679 | $31.4739 | $619.37K |
| May 27, 2026 | Krempa David | Chief Business Officer | M | 7,203 | $3.5800 | $25.79K |
| May 27, 2026 | Krempa David | Chief Business Officer | M | 12,476 | $1.3700 | $17.09K |
| May 26, 2026 | Krempa David | Chief Business Officer | M | 12,524 | $0.0000 | $0.00 |
| May 26, 2026 | Krempa David | Chief Business Officer | M | 25,000 | $0.0000 | $0.00 |
| May 26, 2026 | Krempa David | Chief Business Officer | S | 37,524 | $31.4927 | $1.18M |
| May 26, 2026 | Krempa David | Chief Business Officer | M | 12,524 | $1.3700 | $17.16K |
| May 26, 2026 | Krempa David | Chief Business Officer | M | 25,000 | $1.3800 | $34.50K |
| May 22, 2026 | Krempa David | Chief Business Officer | M | 30,591 | $0.0000 | $0.00 |
| May 22, 2026 | Krempa David | Chief Business Officer | S | 519 | $35.0000 | $18.16K |
| May 22, 2026 | Krempa David | Chief Business Officer | S | 9,315 | $33.8802 | $315.59K |
| May 22, 2026 | Krempa David | Chief Business Officer | S | 32,963 | $33.2208 | $1.10M |
| May 22, 2026 | Krempa David | Chief Business Officer | M | 30,591 | $3.5800 | $109.52K |
| Apr 21, 2026 | RIEDEL NORBERT G | Director | M | 19,655 | $0.0000 | $0.00 |
| Apr 21, 2026 | RIEDEL NORBERT G | Director | M | 12,500 | $0.0000 | $0.00 |