| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Aug 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | M | 5,000 | $0.0000 | $0.00 |
| Aug 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 1,100 | $59.3465 | $65.28K |
| Aug 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 3,900 | $58.3717 | $227.65K |
| Aug 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | M | 5,000 | $2.4800 | $12.40K |
| Aug 17, 2026 | Hohl Benjamin | CHIEF FINANCIAL OFFICER | S | 1,388 | $59.3536 | $82.38K |
| Aug 17, 2026 | Hohl Benjamin | CHIEF FINANCIAL OFFICER | S | 4,630 | $58.3517 | $270.17K |
| Aug 4, 2026 | Derynck Mika K | Director | M | 20,491 | $0.0000 | $0.00 |
| Aug 4, 2026 | Derynck Mika K | Director | M | 23,364 | $0.0000 | $0.00 |
| Aug 4, 2026 | Derynck Mika K | Director | M | 27,567 | $0.0000 | $0.00 |
| Aug 4, 2026 | Derynck Mika K | Director | M | 87,373 | $0.0000 | $0.00 |
| Aug 4, 2026 | Derynck Mika K | Director | S | 158,795 | $60.2134 | $9.56M |
| Aug 4, 2026 | Derynck Mika K | Director | M | 20,491 | $22.4700 | $460.43K |
| Aug 4, 2026 | Derynck Mika K | Director | M | 23,364 | $14.8500 | $346.95K |
| Aug 4, 2026 | Derynck Mika K | Director | M | 27,567 | $25.2800 | $696.89K |
| Aug 4, 2026 | Derynck Mika K | Director | M | 87,373 | $2.4800 | $216.69K |
| Jul 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | M | 5,000 | $0.0000 | $0.00 |
| Jul 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 63 | $53.9208 | $3.40K |
| Jul 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 2,184 | $53.4199 | $116.67K |
| Jul 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 2,063 | $52.3921 | $108.08K |
| Jul 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 459 | $51.5466 | $23.66K |
| Jul 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 231 | $50.0542 | $11.56K |
| Jul 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | M | 5,000 | $2.4800 | $12.40K |
| Jul 17, 2026 | Hohl Benjamin | CHIEF FINANCIAL OFFICER | M | 1,072 | $0.0000 | $0.00 |
| Jul 17, 2026 | Hohl Benjamin | CHIEF FINANCIAL OFFICER | S | 123 | $53.8716 | $6.63K |
| Jul 17, 2026 | Hohl Benjamin | CHIEF FINANCIAL OFFICER | S | 2,638 | $53.3825 | $140.82K |
| Jul 17, 2026 | Hohl Benjamin | CHIEF FINANCIAL OFFICER | S | 2,564 | $52.3180 | $134.14K |
| Jul 17, 2026 | Hohl Benjamin | CHIEF FINANCIAL OFFICER | S | 369 | $51.4823 | $19.00K |
| Jul 17, 2026 | Hohl Benjamin | CHIEF FINANCIAL OFFICER | S | 324 | $49.9715 | $16.19K |
| Jul 17, 2026 | Hohl Benjamin | CHIEF FINANCIAL OFFICER | M | 1,072 | $2.4800 | $2.66K |
| Jul 6, 2026 | Kunkel Lori Anne | Director | S | 5,889 | $50.8442 | $299.42K |
| Jul 6, 2026 | Kunkel Lori Anne | Director | S | 4,111 | $49.9834 | $205.48K |
| Jun 22, 2026 | ORBIMED ADVISORS LLC | 10% Owner | S | 46,776 | $45.0000 | $2.10M |
| Jun 22, 2026 | ORBIMED ADVISORS LLC | 10% Owner | S | 787,024 | $45.3800 | $35.72M |
| Jun 22, 2026 | ORBIMED ADVISORS LLC | 10% Owner | S | 1,477 | $45.0000 | $66.47K |
| Jun 22, 2026 | ORBIMED ADVISORS LLC | 10% Owner | S | 24,846 | $45.3800 | $1.13M |
| Jun 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | M | 5,000 | $0.0000 | $0.00 |
| Jun 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 1,133 | $44.7430 | $50.69K |
| Jun 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 2,599 | $43.8701 | $114.02K |
| Jun 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | S | 1,268 | $42.8270 | $54.30K |
| Jun 17, 2026 | Collins Helen Louise | CHIEF MEDICAL OFFICER | M | 5,000 | $2.4800 | $12.40K |
| Jun 17, 2026 | Hohl Benjamin | CHIEF FINANCIAL OFFICER | M | 6,018 | $0.0000 | $0.00 |
| Jun 17, 2026 | Hohl Benjamin | CHIEF FINANCIAL OFFICER | S | 1,238 | $44.7475 | $55.40K |
| Jun 17, 2026 | Hohl Benjamin | CHIEF FINANCIAL OFFICER | S | 3,401 | $43.8634 | $149.18K |
| Jun 17, 2026 | Hohl Benjamin | CHIEF FINANCIAL OFFICER | S | 1,379 | $42.7850 | $59.00K |
| Jun 17, 2026 | Hohl Benjamin | CHIEF FINANCIAL OFFICER | M | 6,018 | $2.4800 | $14.92K |
| Jun 15, 2026 | ORBIMED ADVISORS LLC | 10% Owner | S | 272,322 | $45.0200 | $12.26M |
| Jun 15, 2026 | ORBIMED ADVISORS LLC | 10% Owner | S | 9,086 | $45.0200 | $409.05K |
| Jun 5, 2026 | Kunkel Lori Anne | Director | S | 354 | $35.8187 | $12.68K |
| Jun 5, 2026 | Kunkel Lori Anne | Director | S | 1,867 | $35.3573 | $66.01K |
| Jun 5, 2026 | Kunkel Lori Anne | Director | S | 7,779 | $34.2794 | $266.66K |