| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jul 21, 2026 | TANG KEVIN | 10% Owner | P | 2,975 | $2.4400 | $7.26K |
| Jul 20, 2026 | TANG KEVIN | 10% Owner | P | 1,623 | $2.4400 | $3.96K |
| Jul 17, 2026 | TANG KEVIN | 10% Owner | P | 265 | $2.4400 | $646.00 |
| Jul 16, 2026 | TANG KEVIN | 10% Owner | P | 18,491 | $2.4400 | $45.12K |
| Jul 15, 2026 | TANG KEVIN | 10% Owner | P | 1,600 | $2.4400 | $3.90K |
| Jul 14, 2026 | TANG KEVIN | 10% Owner | P | 43,878 | $2.4300 | $106.62K |
| Jul 13, 2026 | TANG KEVIN | 10% Owner | P | 48,211 | $2.4200 | $116.67K |
| Jul 10, 2026 | TANG KEVIN | 10% Owner | P | 43,367 | $2.4300 | $105.38K |
| Jul 9, 2026 | TANG KEVIN | 10% Owner | P | 7 | $2.4800 | $17.00 |
| Jul 8, 2026 | TANG KEVIN | 10% Owner | P | 14,338 | $2.4600 | $35.27K |
| Jul 7, 2026 | TANG KEVIN | 10% Owner | P | 15,810 | $2.4800 | $39.21K |
| Jul 6, 2026 | TANG KEVIN | 10% Owner | P | 27,062 | $2.4900 | $67.38K |
| Jul 2, 2026 | TANG KEVIN | 10% Owner | P | 9,821 | $2.4900 | $24.45K |
| Jul 1, 2026 | ARCH Venture Fund IX, L.P. | 10% Owner | M | 16,000 | $0.0000 | $0.00 |
| Jul 1, 2026 | ARCH Venture Fund IX, L.P. | 10% Owner | S | 16,000 | $2.4900 | $39.84K |
| Jul 1, 2026 | ARCH Venture Fund IX, L.P. | 10% Owner | M | 16,000 | $1.0300 | $16.48K |
| Jul 1, 2026 | CRANDELL KEITH | 10% Owner | M | 16,000 | $0.0000 | $0.00 |
| Jul 1, 2026 | CRANDELL KEITH | 10% Owner | S | 16,000 | $2.4900 | $39.84K |
| Jul 1, 2026 | CRANDELL KEITH | 10% Owner | M | 16,000 | $1.0300 | $16.48K |
| Jul 1, 2026 | TANG KEVIN | 10% Owner | P | 71,612 | $2.4900 | $178.31K |
| Jun 30, 2026 | TANG KEVIN | 10% Owner | P | 100 | $2.5000 | $250.00 |
| Jun 30, 2026 | TANG KEVIN | 10% Owner | P | 25,930 | $2.5400 | $65.86K |
| Jun 29, 2026 | TANG KEVIN | 10% Owner | P | 777 | $2.4800 | $1.93K |
| Jun 29, 2026 | TANG KEVIN | 10% Owner | P | 63,985 | $2.4700 | $158.04K |
| Jun 26, 2026 | TANG KEVIN | 10% Owner | P | 134 | $2.5400 | $340.00 |
| Jun 26, 2026 | TANG KEVIN | 10% Owner | P | 75,047 | $2.5500 | $191.37K |
| Jun 25, 2026 | TANG KEVIN | 10% Owner | P | 510 | $2.5600 | $1.30K |
| Jun 25, 2026 | TANG KEVIN | 10% Owner | P | 145,880 | $2.4800 | $361.78K |
| Jun 15, 2026 | Lew Jennifer | Director | A | 32,000 | $0.0000 | $0.00 |
| Jun 15, 2026 | Christensen James | Director | A | 32,000 | $0.0000 | $0.00 |
| Jun 15, 2026 | Lim Jonathan E | Director | A | 48,000 | $0.0000 | $0.00 |
| Jun 15, 2026 | Whiting Nancy | Director | A | 32,000 | $0.0000 | $0.00 |
| Jan 23, 2026 | HINKLE DAVID A | See Remarks | A | 140,000 | $0.0000 | $0.00 |
| Jan 23, 2026 | Oien Jessica | See Remarks | A | 220,000 | $0.0000 | $0.00 |
| Jan 23, 2026 | Hornby Zachary | President & CEO | A | 600,000 | $0.0000 | $0.00 |
| Jan 23, 2026 | Doebele Robert | Chief Medical Officer | A | 230,000 | $0.0000 | $0.00 |
| Jan 23, 2026 | Hassig Christian | Chief Scientific Officer | A | 230,000 | $0.0000 | $0.00 |
| Jun 23, 2025 | Whiting Nancy | Director | A | 16,000 | $0.0000 | $0.00 |
| Jun 23, 2025 | Burow Kristina | Director, 10% Owner | A | 16,000 | $0.0000 | $0.00 |
| Jun 23, 2025 | Lim Jonathan E | Director | A | 24,000 | $0.0000 | $0.00 |
| Jun 23, 2025 | Lew Jennifer | Director | A | 16,000 | $0.0000 | $0.00 |
| Jun 23, 2025 | Christensen James | Director | A | 16,000 | $0.0000 | $0.00 |
| Jun 23, 2025 | Brennan Christine | Director | A | 16,000 | $0.0000 | $0.00 |
| Feb 3, 2025 | Doebele Robert | Chief Medical Officer | A | 180,000 | $0.0000 | $0.00 |
| Jan 22, 2025 | Oien Jessica | See Remarks | A | 90,000 | $0.0000 | $0.00 |
| Jan 22, 2025 | Hornby Zachary | President & CEO | A | 295,000 | $0.0000 | $0.00 |
| Jan 22, 2025 | Hassig Christian | Chief Scientific Officer | A | 95,000 | $0.0000 | $0.00 |
| Jan 22, 2025 | HINKLE DAVID A | See Remarks | A | 65,000 | $0.0000 | $0.00 |
| Aug 19, 2024 | Wagner Klaus W. | Chief Medical Officer | A | 41,745 | – | – |
| Aug 19, 2024 | Wagner Klaus W. | Chief Medical Officer | A | 68,080 | – | – |